Recombinant Full Length Human IFNGR2 Protein, C-Flag-tagged

• Cat.No.: IFNGR2-1609HFL
• Product Overview: Recombinant Full Length Human IFNGR2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 35 kDa
• AA Sequence: MRPTLLWSLLLLLGVFAAAAAAPPD PLSQLPAPQHPKIRLYNAEQVLSWE PVALSNSTRPVVYQVQFKYT DSKWFTADIMSIGVNCTQITATECD FTAASPSAGFPMDFNVTLRLRAELG ALHSAWVTMPWFQHYRNVTV GPPENIEVTPGEGSLIIRFSSPFDI ADTSTAFFCYYVHYWEKGGIQQVKG PFRSNSISLDNLKPSRVYCL QVQAQLLWNKSNIFRVGHLSNISCY ETMADASTELQQVILISVGTFSLLS VLAGACFFLVLKYRGLIKYW
  FHTPPSIPLQIEEYLKDPTQPILEA LDKDSSPKDDVWDSVSIISFPEKEQ EDVLQTLTRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity

Gene Information

• Gene Name: IFNGR2 interferon gamma receptor 2 [ Homo sapiens (human) ]
• Official Symbol: IFNGR2
• Synonyms: AF-1; IFGR2; IMD28; IFNGT1
• Gene ID: 3460
• mRNA Refseq: NM_005534.4
• Protein Refseq: NP_005525.2
• MIM: 147569
• UniProt ID: P38484