KDM1A
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Official Full Name
lysine (K)-specific demethylase 1A
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Overview
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] -
Synonyms
KDM1A; lysine (K)-specific demethylase 1A; AOF2; KDM1; LSD1; BHC110; lysine-specific histone demethylase 1A; lysine (K)-specific demethylase 1; BRAF35-HDAC complex protein BHC110; lysine-specific histone demethylase 1; amine oxidase (flavin containing) domain 2; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; flavin-containing amine oxidase domain-containing protein 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- KDM1A Related Signal Pathway
KDM1A involved in several pathways and played different roles in them. We selected most pathways KDM1A participated on our site, such as Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3, Androgen receptor signaling pathway, Chromatin modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | HIST3H2BB;NCOA2;KDM4C;KDM1A;HIST4H4;HIST2H3C |
| Androgen receptor signaling pathway | PNRC1;RHOB;SVILA;ZMIZ1;KDM1A;HMGB2A;CTNNB2;CREBBP;SMARCE1 |
| Chromatin modifying enzymes | GATAD2A;ELP3;BRD8;CSRP2BP;PHF20B;JMJD6;PHF17;MCRS1;ASH2L |
| Chromatin organization | ELP2;KDM1A;KAT6B;MSL3;ING4;CAPNS2;TAF6L;KDM2AA;JADE1 |
| Coregulation of Androgen receptor activity | CTDSP2;CARM1;NRIP1;MAK;SVIL;CTDSP1;CMTM2;PATZ1;KDM4C |
| Factors involved in megakaryocyte development and platelet production | HBBE2;HBBE1.1;KIF9;BA1;AKAP1;KDM1A;PHF21A;ITPK1;GATA1 |
| HDACs deacetylate histones | MBD3A;MBD3;MBD3B;GATAD2A;MTA3;HMG20B;SAP30;CHD4A;CHD4 |
| HDMs demethylate histones | KDM3B;KDM4D;KDM5BB;KDM2A;KDM2B;KDM5A;KDM5B;KDM4B;ARID5B |
KDM1A has several biochemical functions, for example, MRF binding, RNA polymerase II transcription factor binding, androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM1A itself. We selected most functions KDM1A had, and list some proteins which have the same functions with KDM1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MRF binding | CREBBP;KDM1A;TSC22D3;BHLHE40 |
| RNA polymerase II transcription factor binding | GFI1B;MTA2;GSC;HCLS1;PITX2;TP53;GATA2A;MKX;XBP1 |
| androgen receptor binding | PIAS1;KAT5;FOXP1;KDM1A;PKN1;TRIM68;SMARCA4;CALR;PRPF6 |
| chromatin binding | MECP2;PSIP1;KLHDC3;WHSC1;CHAF1B;SKI;SIRT6;DNMT3B;ZNF143 |
| demethylase activity | CYP3A41B;CYP1A1;KDM1A;CYP3A41A;CYP1A2;ALKBH4 |
| enzyme binding | TP53;CFTR;GRIN1;HNRNPUL1;CYP2A4;NFKBIA;PYCARD;TSPAN15;CBX1 |
| flavin adenine dinucleotide binding | SQLEA;GSR;LDHD;CHDH;PPOX;GCDHB;DUS4L;FMO5;SQLE |
| histone demethylase activity | KDM1A;PHF8;KDM2B;KDM4C |
| histone demethylase activity (H3-K4 specific) | KDM5D;KDM5B;KDM1A;C14orf169;KDM5C |
| histone demethylase activity (H3-K9 specific) | KDM7AB;KDM4D;KDM1A;JHDM1D;PHF2;KDM4C;PHF8 |
| histone demethylase activity (H3-dimethyl-K4 specific) | KDM1B;KDM5BB;KDM5B;KDM1A |
| ligand-dependent nuclear receptor transcription coactivator activity | NCOA2;ENY2;DCAF6;ZCCHC18;THRAP3;CARM1;WDR77;HELZ2;PRKCB |
| oxidoreductase activity | YWHAQA;FAXDC2;RDH1;DHRS13B;KIAA1191;LOXL2B;DMGDH;CYP2J6;ADH8B |
| p53 binding | ZNF385C;TRIM24;MSX1;SMARCB1;TAF9;HSPD1;CHD8;BRD4;GATA1 |
| protein binding | F11R;BCR;DPEP1;MAFB;PPP6C;TJP1;CTSC;CECR2;FOXL2 |
| transcription factor activity, sequence-specific DNA binding | NFYB;NFE2L1B;SOX5;ATF5;REL;TRERF1;ZNF567;E2F8;FOXB1B |
| transcription factor binding | CTBP1;NEUROD1;TCF3;NBN;DRAP1;IRF4;HES1;RARA;TRIB2 |
| transcription regulatory region DNA binding | FOXI1;TBP;KLF2A;TBX21;PROX1;ZFHX3;MTERFD3;JUN;HIVEP2 |
KDM1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM1A here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM1A.
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