klk7
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  • Official Full Name
  • kallikrein-related peptidase 7
  • Background
  • This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
  • Synonyms
  • KLK7; kallikrein-related peptidase 7; hK7; SCCE; PRSS6; kallikrein-7; signal protein; serine protease 6; stratum corneum chymotryptic enzyme; kallikrein 7 (chymotryptic, stratum corneum)
Cat.#:KLK7-564MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse KLK7 Protein, His-tagged
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Cat.#:KLK7-4930HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human KLK7 Protein, GST-tagged
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Cat.#:KLK7-689HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human KLK7 Protein, MYC/DDK-tagged
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Cat.#:KLK7-1359HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Kallikrein-Related Peptidase 7
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Cat.#:KLK7-7169HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Kallikrein-Related Peptidase 7, His-tagged
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Cat.#:KLK7-1959HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KLK7 protein, His & GST-tagged
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Cat.#:KLK7-26893THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human KLK7
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Cat.#:KLK7-893HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human KLK7, His tagged
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Cat.#:KLK7-894HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human KLK7
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Cat.#:Klk7-1960MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Klk7 protein, His & GST-tagged
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Cat.#:Klk7-7405MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Klk7, His-tagged
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Cat.#:Klk7-1961RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Klk7 protein, His & GST-tagged
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Cat.#:KLK7-2428HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human KLK7 cell lysate
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Cat.#:KLK7-1421MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse KLK7 cell lysate
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Involved Pathway

KLK7 involved in several pathways and played different roles in them. We selected most pathways KLK7 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Degradation of the extracellular matrix
TIMP2; TIMP2A; ADAM15; ADAM8; MMP19; MGC174857; NID1; CTSL1; TLDC2; COL15A1B
Extracellular matrix organization
BMP10; CTSB; PCOLCE2B; MFAP5; SERPINH1A; F11R.2; COL3A1; DDR1; ADAMTS8; SPARC

Protein Function

KLK7 has several biochemical functions, for example, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLK7 itself. We selected most functions KLK7 had, and list some proteins which have the same functions with KLK7. You can find most of the proteins on our site.
Function
Related Protein
Function peptidase activity
Related Protein TMPRSS11D; HTRA2; CLPP; KLK1B1; TRY; GZMC; DUB1; CAPN1A; FURINA; MCPT8
Function serine-type endopeptidase activity
Related Protein GZME; TMPRSS13A; F11; KLK1B3; PLG; F2; PCSK1; C1R; PRSS23; TMPRSS4
Function serine-type peptidase activity
Related Protein F9A; KLK1B26; Gzmg; PARLA; PCSK5B; TMPRSS13A; SLC38A8; PRSS59.2; KLK1B1; KLK1B5

Interacting Protein

KLK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLK7.
BAG4; CHEK2; TGFB1; PTPN1; WT1; CCND1; PTPRJ; STK11

KLK7 Related Articles

Yamamuro, T; Hori, M; et al. Tickling stimulation causes the up-regulation of the kallikrein family in the submandibular gland of the rat. BEHAVIOURAL BRAIN RESEARCH 236:236-243(2013).
Yamamoto, M; Miyai, M; et al. Kallikrein-related Peptidase-7 Regulates Caspase-14 Maturation during Keratinocyte Terminal Differentiation by Generating an Intermediate Form. JOURNAL OF BIOLOGICAL CHEMISTRY 287:32825-32834(2012).