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KLK7

  • Official Full Name

    kallikrein-related peptidase 7

  • Overview

    This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
  • Synonyms

    KLK7; kallikrein-related peptidase 7; hK7; SCCE; PRSS6; kallikrein-7; signal protein; serine protease 6; stratum corneum chymotryptic enzyme; kallikrein 7 (chymotryptic, stratum corneum);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KLK7-1359H Active Recombinant Human Kallikrein-Related Peptidase 7 Human N/A
Human KLK7-894H Active Recombinant Human KLK7 HEK293 N/A
Human KLK7-1959H Recombinant Human KLK7 protein, His & GST-tagged E.coli His/GST Glu23~Arg253 (Accession # P49862)
Human KLK7-7169H Recombinant Human Kallikrein-Related Peptidase 7, His-tagged E.coli His 30-253aa
Human KLK7-26893TH Recombinant Human KLK7 Wheat Germ N/A 100 amino acids
Human KLK7-893H Recombinant Human KLK7, His tagged Human Cell His
Human KLK7-2428HCL Recombinant Human KLK7 cell lysate Human Cell N/A
Human KLK7-4930H Recombinant Human KLK7 Protein, GST-tagged Wheat Germ GST
Human KLK7-689H Recombinant Human KLK7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human KLK7-2375H Recombinant Human KLK7 Protein, His-tagged E.coli N-His Glu23-Arg253
Human KLK7-889H Recombinant Human KLK7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human KLK7-5458H Recombinant Human KLK7 protein, His-tagged Yeast His 28-253aa
Human KLK7-080H Recombinant Human KLK7 Protein, His-tagged HEK293 His 253
Human KLK7-5864HF Recombinant Full Length Human KLK7 Protein, GST-tagged In Vitro Cell Free System GST 253 amino acids
Human KLK7-3139H Recombinant Human KLK7 protein, GST-tagged E.coli GST 28-253aa
Human KLK7-2942H Recombinant Human KLK7 Protein (Glu23-His252), C-His tagged Mammalian cells C-His Glu23-His252
Human KLK7-5019H Recombinant Human KLK7 Protein (Glu23-Arg253), N-GST tagged E.coli N-GST Glu23-Arg253
Mouse Klk7-7405M Active Recombinant Mouse Klk7 protein, His-tagged HEK293 His Met1-Arg249
Mouse Klk7-1960M Recombinant Mouse Klk7 protein, His & GST-tagged E.coli His/GST Tyr30-Arg249 (Accession # Q91VE3)
Mouse KLK7-1421MCL Recombinant Mouse KLK7 cell lysate Human Cell N/A
Mouse KLK7-564M Active Recombinant Mouse KLK7 Protein, His-tagged Mammalian cells His Gln22-Arg249
Mouse Klk7-3726M Recombinant Mouse Klk7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse KLK7-4880M-B Recombinant Mouse KLK7 Protein Pre-coupled Magnetic Beads HEK293
Mouse KLK7-4880M Recombinant Mouse KLK7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Klk7-5784M Recombinant Mouse Klk7 Protein (Gln22-Arg249), C-His tagged Mammalian cells C-His Gln22-Arg249
Rat Klk7-1961R Recombinant Rat Klk7 protein, His & GST-tagged E.coli His/GST Arg24~Glu255
Rat Klk7-3140R Recombinant Rat Klk7 protein, His-tagged E.coli His 25-261aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KLK7 Related Articles
  • KLK7 Related Research Area

KLK7 involved in several pathways and played different roles in them. We selected most pathways KLK7 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Degradation of the extracellular matrixTLL1;CTSL2;CTSG;MMP17;MMP12;COL13A1;BMP1A;ADAMTS4;COL15A1B
Extracellular matrix organizationLTBP4;DMD;COL4A6;TTR;CAPNS1;MMP8;PCOLCEA;COL9A1A;COL23A1

KLK7 has several biochemical functions, for example, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLK7 itself. We selected most functions KLK7 had, and list some proteins which have the same functions with KLK7. You can find most of the proteins on our site.

Function Related Protein
peptidase activityCAPN12;NAPSA;PSMA6B;DESI2;PRSS42;CAPN5A;OVCH2;TMPRSS4B;GM5136
serine-type endopeptidase activityGZMB;TMPRSS15;CELA2A;PRSS59.2;HTRA3A;PLAUB;CTRL;HPN;PRSS52
serine-type peptidase activityAcr;KLK4;TMPRSS13A;PRSS28;FURINA;EGFBP2;TPSB2;IMMP2L;KLK1B11

KLK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLK7.

BAG4; CHEK2; TGFB1; PTPN1; WT1; CCND1; PTPRJ; STK11

Yamamuro, T; Hori, M; et al. Tickling stimulation causes the up-regulation of the kallikrein family in the submandibular gland of the rat. BEHAVIOURAL BRAIN RESEARCH 236:236-243(2013).
Yamamoto, M; Miyai, M; et al. Kallikrein-related Peptidase-7 Regulates Caspase-14 Maturation during Keratinocyte Terminal Differentiation by Generating an Intermediate Form. JOURNAL OF BIOLOGICAL CHEMISTRY 287:32825-32834(2012).
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