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LEFTY1

  • Official Full Name

    left-right determination factor 1

  • Overview

    This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008]
  • Synonyms

    LEFTY1; left-right determination factor 1; LEFTB; LEFTYB; protein lefty-1; protein lefty-B; left-right determination factor B; left-right determination, factor B;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Fc
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human Lefty1-1915H Active Recombinant Human Left-right Determination Factor 1 HEK293 N/A
Human LEFTY1-980HCL Recombinant Human LEFTY1 cell lysate N/A
Human LEFTY1-367H Recombinant Human LEFTY1 Protein, His-tagged E.coli His Phe78~Pro361
Human LEFTY1-3923H Recombinant Human LEFTY1 Protein (Phe78-Pro361), His tagged E.coli His Phe78-Pro361
Human LEFTY1-003H Recombinant Human LEFTY1 Protein, Fc-tagged HEK293 Fc
Mouse Lefty1-579M Active Recombinant Mouse Left Right Determination Factor 1 E.coli N/A
Mouse Lefty1-629M Active Recombinant Mouse Lefty1 Mammalian cells N/A
Mouse Lefty1-1765M Recombinant Mouse Left Right Determination Factor 1 Mammalian cells N/A
Mouse LEFTY1-9036M Recombinant Mouse LEFTY1 Protein Mammalian Cell His
Mouse LEFTY1-5033M Recombinant Mouse LEFTY1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Lefty1-370M Recombinant Mouse Lefty1 Protein, His/GST-tagged E.coli His/GST Ser169~Pro368
Mouse Lefty1-10587M Recombinant Mouse Lefty1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse LEFTY1-5033M-B Recombinant Mouse LEFTY1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Lefty1-10587M-B Recombinant Mouse Lefty1 Protein Pre-coupled Magnetic Beads HEK293
Rat Lefty1-371R Recombinant Rat Lefty1 Protein, His/GST-tagged E.coli His/GST Ser169~Pro368
Rat LEFTY1-27R Recombinant Rat LEFTY1, His-tagged HEK293 His
Cynomolgus Monkey LEFTY1-28C Recombinant Cynomolgus Monkey LEFTY1, His-tagged HEK293 His
Cynomolgus Monkey LEFTY-001C Recombinant Cynomolgus Monkey LEFTY1 Protein, His-Tagged HEK293 His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

LEFTY1 involved in several pathways and played different roles in them. We selected most pathways LEFTY1 participated on our site, such as Developmental Biology, Integrated Pancreatic Cancer Pathway, Regulation of signaling by NODAL, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEFTY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Developmental BiologyCRMP1;RHOB;CDON;CSNK2A2;RASGRP4;SPTA1;MED29;DUSP1;CACNG3
Integrated Pancreatic Cancer PathwayNOXA1;MYT1;FKBP1B;TOP2A;BRF1;CST3;DAXX;JUND;TOP1
Regulation of signaling by NODALTDGF1;CFC1;LEFTY1;ACVR1C
Signaling by NODALFOXH1;ACVR1C;DRAP1;GDF1;PCSK6;CFC1;LEFTY1;TDGF1
TGF Beta Signaling PathwayTGFBR3;NOG;ZNF423;FOXH1;FST;ZFP423;ENG;LEFTY1;RUNX3
TGF-beta signaling pathwayBMPR1BA;GDF7;ID1;TGFBR2;GDF5;ACVR1B;ID4;CUL1;PITX2

LEFTY1 has several biochemical functions, for example, cytokine activity, growth factor activity, transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEFTY1 itself. We selected most functions LEFTY1 had, and list some proteins which have the same functions with LEFTY1. You can find most of the proteins on our site.

Function Related Protein
cytokine activityGPI;TNFRSF11B;GDF15;IFNPHI1;IFNPHI4;IL21;CSF3;IL36G;TNFSF10
growth factor activityNDP;LFT2;MIA1;FGF11;F2;CNTF;INHBAA;IGF2B;GPI1
transforming growth factor beta receptor bindingBMP7;BMP4;BMP5;BMP3;GDF9;GDF1;BMP6;BMP2B;SMAD3

LEFTY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEFTY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEFTY1.

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can LEFTY1 be used in combination with other treatments? 03/28/2022

Combination therapies involving LEFTY1 are being investigated to enhance treatment efficacy and reduce the risk of resistance development.

Are there any ongoing clinical trials involving LEFTY1? 09/11/2018

Some clinical trials are exploring the therapeutic potential of LEFTY1, particularly in cancer treatment and tissue regeneration.

How does LEFTY1 interact with other signaling pathways in the body? 05/16/2018

LEFTY1 interacts with various signaling pathways, influencing cellular processes involved in development, immune response, and disease progression.

How is LEFTY1 protein associated with clinical applications? 12/22/2017

LEFTY1 has shown potential clinical applications in various fields, including cancer research and regenerative medicine.

How does LEFTY1 contribute to tissue regeneration? 06/27/2017

LEFTY1 has demonstrated the ability to influence stem cell differentiation and tissue repair, making it a potential candidate for regenerative medicine.

Customer Reviews (3)

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Reviews
02/12/2021

    The knowledgeable and experienced support team is readily available to address any questions or concerns that researchers may have throughout their experimental journey.

    08/22/2018

      Its stability and reliability warrant its inclusion in my research protocols, leading to meaningful and conclusive results.

      10/02/2016

        Their prompt and effective responses help ensure smooth and efficient progress, indeed solving any problem that arises.

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