lefty1
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  • Official Full Name
  • left-right determination factor 1
  • Background
  • This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • LEFTY1; left-right determination factor 1; LEFTB; LEFTYB; protein lefty-1; protein lefty-B; left-right determination factor B; left-right determination, factor B;
Cat.#:LEFTY1-367HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEFTY1 Protein, His-tagged
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Cat.#:Lefty1-370MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lefty1 Protein, His/GST-tagged
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Cat.#:Lefty1-371RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lefty1 Protein, His/GST-tagged
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Cat.#:Lefty1-579MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Left Right Determination Factor 1
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Cat.#:Lefty1-1915HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Left-right Determination Factor 1
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Cat.#:Lefty1-1765MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Left Right Determination Factor 1
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Cat.#:Lefty1-629MTag:
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Lefty1
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Cat.#:LEFTY1-9036MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LEFTY1 Protein
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Cat.#:LEFTY1-980HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LEFTY1 cell lysate
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Involved Pathway

LEFTY1 involved in several pathways and played different roles in them. We selected most pathways LEFTY1 participated on our site, such as Developmental Biology, Integrated Pancreatic Cancer Pathway, Regulation of signaling by NODAL, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEFTY1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Developmental Biology
NADL1.1; COL4A5; FOXD3; KALRNB; CEBPA; CACNG3; DPYSL5B; CEBPB; RHOB; MED31
Integrated Pancreatic Cancer Pathway
FKBP3; GPRC5A; FKBP1B; MYT1; TFF1; IL11; CST3; CD82; JUND; BRF1
Regulation of signaling by NODAL
ACVR1C; CFC1; TDGF1; LEFTY1
Signaling by NODAL
FOXH1; GDF1; LEFTY1; ACVR1C; TDGF1; PCSK6; DRAP1; CFC1
TGF Beta Signaling Pathway
LEFTY1; ZFP423; RUNX3; FOXH1; ENG; ZNF423; FST; TGFBR3; NOG
TGF-beta signaling pathway
RBX1; SP1; BMPR2A; GDF5; BMP7B; RPS6KB1; GDF7; TGFBR1A; INHBC; PPP2R1B

Protein Function

LEFTY1 has several biochemical functions, for example, cytokine activity, growth factor activity, transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEFTY1 itself. We selected most functions LEFTY1 had, and list some proteins which have the same functions with LEFTY1. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein Ifnl2; TNFB; NRG1; IFNB1; IFNA7; GDF7; IFNA13; HMGB1; IFNT2; IFNK
Function growth factor activity
Related Protein NUDT6; MIA1; FGF12B; JAG1; TIMP1; CSF2; Kitl; TFF1; NRG3; BMP8A
Function transforming growth factor beta receptor binding
Related Protein BMP10; AMH; GDF1; INHBAB; TGFBRAP1; LRG1; SPAW; GDF2; GDF6; NODAL