LEFTY1
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Official Full Name
left-right determination factor 1
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Overview
This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008] -
Synonyms
LEFTY1; left-right determination factor 1; LEFTB; LEFTYB; protein lefty-1; protein lefty-B; left-right determination factor B; left-right determination, factor B;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cell
- Mammalian cells
- Fc
- His
- His (Fc)
- Avi
- His|GST
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
LEFTY1 involved in several pathways and played different roles in them. We selected most pathways LEFTY1 participated on our site, such as Developmental Biology, Integrated Pancreatic Cancer Pathway, Regulation of signaling by NODAL, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEFTY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Developmental Biology | CRMP1;RHOB;CDON;CSNK2A2;RASGRP4;SPTA1;MED29;DUSP1;CACNG3 |
Integrated Pancreatic Cancer Pathway | NOXA1;MYT1;FKBP1B;TOP2A;BRF1;CST3;DAXX;JUND;TOP1 |
Regulation of signaling by NODAL | TDGF1;CFC1;LEFTY1;ACVR1C |
Signaling by NODAL | FOXH1;ACVR1C;DRAP1;GDF1;PCSK6;CFC1;LEFTY1;TDGF1 |
TGF Beta Signaling Pathway | TGFBR3;NOG;ZNF423;FOXH1;FST;ZFP423;ENG;LEFTY1;RUNX3 |
TGF-beta signaling pathway | BMPR1BA;GDF7;ID1;TGFBR2;GDF5;ACVR1B;ID4;CUL1;PITX2 |
LEFTY1 has several biochemical functions, for example, cytokine activity, growth factor activity, transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEFTY1 itself. We selected most functions LEFTY1 had, and list some proteins which have the same functions with LEFTY1. You can find most of the proteins on our site.
Function | Related Protein |
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cytokine activity | GPI;TNFRSF11B;GDF15;IFNPHI1;IFNPHI4;IL21;CSF3;IL36G;TNFSF10 |
growth factor activity | NDP;LFT2;MIA1;FGF11;F2;CNTF;INHBAA;IGF2B;GPI1 |
transforming growth factor beta receptor binding | BMP7;BMP4;BMP5;BMP3;GDF9;GDF1;BMP6;BMP2B;SMAD3 |
LEFTY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEFTY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEFTY1.
- Q&As
- Reviews
Q&As (5)
Ask a questionCombination therapies involving LEFTY1 are being investigated to enhance treatment efficacy and reduce the risk of resistance development.
Some clinical trials are exploring the therapeutic potential of LEFTY1, particularly in cancer treatment and tissue regeneration.
LEFTY1 interacts with various signaling pathways, influencing cellular processes involved in development, immune response, and disease progression.
LEFTY1 has shown potential clinical applications in various fields, including cancer research and regenerative medicine.
LEFTY1 has demonstrated the ability to influence stem cell differentiation and tissue repair, making it a potential candidate for regenerative medicine.
Customer Reviews (3)
Write a reviewThe knowledgeable and experienced support team is readily available to address any questions or concerns that researchers may have throughout their experimental journey.
Its stability and reliability warrant its inclusion in my research protocols, leading to meaningful and conclusive results.
Their prompt and effective responses help ensure smooth and efficient progress, indeed solving any problem that arises.
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