loxl4
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  • Official Full Name
  • lysyl oxidase-like 4
  • Background
  • This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
  • Synonyms
  • LOXL4; lysyl oxidase-like 4; LOXC; lysyl oxidase homolog 4; lysyl oxidase related C; lysyl oxidase-like protein 4; lysyl oxidase-like 4 pseudogene; lysyl oxidase-related protein C;
Cat.#:LOXL4-280HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LOXL4 Protein, His-tagged
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Cat.#:LOXL4-194HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human LOXL4 protein, GST-tagged
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Cat.#:LOXL4-2157HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LOXL4 protein, GST-tagged
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Cat.#:LOXL4-2158HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LOXL4 protein, His-tagged
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Cat.#:LOXL4-2159HTag:FLAG
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human LOXL4 protein, FLAG-tagged
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Cat.#:LOXL4-28220THTag:
Source (Host):Species:Human
Product nameRecombinant Human LOXL4
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Cat.#:LOXL4-4676HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LOXL4 293 Cell Lysate
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Involved Pathway

LOXL4 involved in several pathways and played different roles in them. We selected most pathways LOXL4 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOXL4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of collagen fibrils and other multimeric structures
COL4A4; LOXL4; COL3A1; COL5A3A; CTSL1; LOXL1; TLL2; DST; ABHD1; BMP1B
Collagen formation
COL17A1; LOXL4; COL1A2; COL11A1B; COL15A1B; P3H2; COL10A1; COL28A1A; COL4A4; COL5A1
Crosslinking of collagen fibrils
LOXL2; BMP1B; TLL1; LOXL3; LOXL4; PCOLCE; BMP1; LOXL1; ABHD1; TLL2
Elastic fibre formation
ITGB3A; FBN1; EFEMP1; LTBP4; MFAP5; LTBP2; ABHD1; MFAP2; FBLN2; FBN2
Extracellular matrix organization
ADAMTS8; MMP19; CTSD; FMOD; CMA1; CAPNS1; PCOLCEA; COL9A1B; COL28A1; COL28A1D

Protein Function

LOXL4 has several biochemical functions, for example, copper ion binding, protein binding, protein-lysine 6-oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LOXL4 itself. We selected most functions LOXL4 had, and list some proteins which have the same functions with LOXL4. You can find most of the proteins on our site.
Function
Related Protein
Function copper ion binding
Related Protein PRND; F5; MOXD1; LOXL3A; SCO2; HIST2H3A; ANG; SERPINB1A; LOXL3; HEPHL1
Function protein binding
Related Protein ZFPM2A; GPA33; BPTF; PTPRR; ZBED1; UBE2E2; UNC45A; ASS1; NFKB1; C19orf10
Function protein-lysine 6-oxidase activity
Related Protein POLR1B; LOXL2A; LOXL3; LOXL2B; ABHD1; LOXL4; LOXL2; LOX
Function scavenger receptor activity
Related Protein PRSS12; ENDOU; TMPRSS13B; ACKR4; SCARF1; SUSD2; TMPRSS4B; CD5; COLEC12; CCBP2

Interacting Protein

LOXL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOXL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LOXL4.
TRIP13; KDM1A; PRMT6; SUV39H1; APOE; LONP1; RAD23A; CDC37; EXOC6; ECSIT; MAST1