MAP2K4 Protein, mitogen-activated protein kinase kinase 4

MAP2K4

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MAP2K4

Official Full Name mitogen-activated protein kinase kinase 4
Background SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of se
Synonyms MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; dual specificity mitogen-activated protein kinase kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; MAP kinase kinase 4; JNK-activated kinase
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Human
    • Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • SUMO
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K4-17H Recombinant Human MAP2K4 Protein, GST-tagged E.coli GST
    Mouse MAP2K4-641M Recombinant Mouse MAP2K4 Protein (2-397 aa), His-SUMO-tagged E.coli His/SUMO
    Human MAP2K4-105H Recombinant Human MAP2K4, His-tagged Sf9 Insect Cell His
    Human MAP2K4-304H Recombinant Human MAP2K4 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K4-33H Recombinant human biotinylated MAP2K4, His-tagged E.coli His
    Human MAP2K4-394H Recombinant Human MAP2K4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP2K4-597H Recombinant Human Mitogen-Activated Protein Kinase kinase 4, His-tagged Human His
    Human MAP2K4-8086H Recombinant Human MAP2K4 protein, His & GST-tagged E.coli His/GST
    Mouse Map2k4-1351M Recombinant Mouse Map2k4, His & GST tagged Insect Cell His/GST
    Mouse MAP2K4-557MCL Recombinant Mouse MAP2K4 cell lysate Insect Cell N/A

    MAP2K4 involved in several pathways and played different roles in them. We selected most pathways MAP2K4 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PDGFA; MAP2K4B; TP53; CDC42; PAK1; IL1B; PPM1AA; CACNA1SB; FGF22; CACNB2
    ErbB signaling pathway PAK3; CDKN1BA; ARAF; BAD; PIK3R3A; MTOR; PIK3CA; CAMK2B1; PIK3R2; PIK3R1
    Toll-like receptor signaling pathway IFNA16; RIPK1L; CXCL11; TLR2-1; TLR2; IFNPHI1; MAPK1; IL-8; IFNA5; AKT1
    Fc epsilon RI signaling pathway VAV3; LAT; RAC2; FCER1G; PIK3R3; AKT1; NRAS; MAPK1; PIK3R5; MAP2K4
    TNF signaling pathway CCL20; TNFRSF1B; MAPK10; ATF4; VCAM1; MMP9; PIK3CB; MAPK8; MAPK13; MLKL
    GnRH signaling pathway MAPK9; GNA11; HRAS; GNRH2; ADCY2B; CAMK2B1; PRKCD; CACNA1SB; CALML5; CAMK2A
    Epithelial cell signaling in Helicobacter pylori infection CXCR2; ATP6V1F; ATP6V1C2; ATP6V0A1; IKBKB; ATP6V1C1; PLCG1; RAC1; ATP6V1A; MAP3K14
    Chagas disease (American trypanosomiasis) IKBKG; PIK3R5; PPP2R2C; PLCB2; NFKB1; PLCB1; PIK3CB; PPP2R2D; NFKBIA; MAPK11
    Hepatitis B RELA; IRF3; MAVS; TGFB3; NFATC4; DDX3X; CASP10; RB1; IFN-a; NFKB1
    Influenza A HLA-DQA2; PABPN1L; PRKCA; BLA; TYK2; NFKB1; NXT2; TMPRSS4; IFNA16; IFNA2
    HTLV-I infection ANAPC1; ITGB2; PTTG1; ANAPC11; PPP3CC; STAT5A; FOSL1; PPP3CB; FZD1; CCND3
    Epstein-Barr virus infection BCL2; TRADD; IL10RB; PRKACB; TRAF2; PSMD2; POLR2A; POLR2L; AKAP8L; PSMC1

    MAP2K4 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K4 itself. We selected most functions MAP2K4 had, and list some proteins which have the same functions with MAP2K4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TNIK; UHMK1; TEP1; TRMU; ACSBG1; ADCY9; PIP5K1B; MAP4K2; LANCL2; UCK2
    protein binding SMC4; ACVR2B; CCDC64; NTRK3; EIF2S1; DDR2; AMPH; KCTD15; RUNX3; GPRASP1
    protein kinase activity CDK14; TAOK1; SBK1; CSF1RA; PRKG1A; DCLK2; TEK; GM4922; HIPK3A; PRPF4BA
    protein serine/threonine kinase activity MAP2K6; TAF1; PRKACBB; PSKH1; CLK1; BMPR1BA; ACVR1L; CASK; HIPK1; GRK1A
    protein tyrosine kinase activity MAP3K9; FER; KIT; TNK1; TEK; ROS1; NTRK3A; MAP2K1; LCK; CAMKK2

    MAP2K4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K4.

    MAP3K1; ARRB2; MAPK8; ARRB1; CFLAR; yopP; Arrb2; TRIB1; FBP2; ALDOB; MAPK9; STX17; CYLC2; RBBP8; pi3p; npm_alk

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