map2k4
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  • Official Full Name
  • mitogen-activated protein kinase kinase 4
  • Background
  • SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of se
  • Synonyms
  • MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; dual specificity mitogen-activated protein kinase kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; MAP kinase kinase 4; JNK-activated kinase
Cat.#:MAP2K4-17HTag:GST
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human MAP2K4 Protein, GST-tagged
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Cat.#:MAP2K4-641MTag:His-SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse MAP2K4 Protein (2-397 aa), His-SUMO-tagged
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Cat.#:MAP2K4-394HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAP2K4 Protein, MYC/DDK-tagged
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Cat.#:MAP2K4-105HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAP2K4, His-tagged
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Cat.#:MAP2K4-304HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K4 protein, His/MBP-tagged
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Cat.#:MAP2K4-33HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated MAP2K4, His-tagged
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Cat.#:MAP2K4-8086HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K4 protein, His & GST-tagged
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Cat.#:Map2k4-1351MTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Map2k4, His & GST tagged
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Cat.#:MAP2K4-597HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase kinase 4, His-tagged
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Cat.#:MAP2K4-557MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse MAP2K4 cell lysate
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Involved Pathway

MAP2K4 involved in several pathways and played different roles in them. We selected most pathways MAP2K4 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP2K4; GRB2B; MAP2K2; FGF1; PRKACB; PPM1B; MAP3K3; PRKCA; ECSIT; MEF2CB
ErbB signaling pathway
PIK3R2; AREG; NCK1; PIK3R1; HBEGFB; MAPK8A; MAPK9; PIK3CG; NRG1; MYCB
Toll-like receptor signaling pathway
IL-8; IKBKG; Ifna15; TLR8; TLR4BA; MAPK10; CXCL11; CASP8; TLR5; FOS
Fc epsilon RI signaling pathway
RAF1; PLCG2; MAP2K7; PIK3R3; MAP2K3; SYK; MAPK10; PIK3R5; PLA2G4C; SOS1
TNF signaling pathway
BAG4; MAPK12; PIK3CD; BIRC2; CREB3L3; CXCL1; TRAF2; SOCS3; FAS; MAP2K6
GnRH signaling pathway
ADCY1B; CAMK2B1; CAMK2A; PLD1; CACNA1D; CDC42L; GNRHR4; MAPK7; MMP14B; MAP3K1
Epithelial cell signaling in Helicobacter pylori infection
NFKB1; MET; SRC; CXCR2; ADAM17; ATP6V0B; MAPK13; IKBKB; PLCG2; ATP6AP1
Chagas disease (American trypanosomiasis)
IL1B2; IFNG; NOS2; MAPK1; PLCB3; FADD; MAPK8; C3; ACE; MAP2K4
Hepatitis B
ATF4; NFKB1; CASP12; APAF1; PRKCA; CASP10; IFNA10; IFNA2; Ifna11; MAP2K4
Influenza A
CXCL8; PIK3R3; HNRNPUL1; AGFG1; IFNA3; PIK3R2; CASP9; NLRP3; ACTG1; PABPN1L
HTLV-I infection
TGFB2; CDC20; ANAPC4; ANAPC2; NFATC1; WNT8B; IL6; BAX; GPS2; IL1R1
Epstein-Barr virus infection
PSMD13; RELB; RAN; POLR3K; H2-Q10; HLA-DPA1; TRAF3; PSMC5; HSPB2; TP53

Protein Function

MAP2K4 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K4 itself. We selected most functions MAP2K4 had, and list some proteins which have the same functions with MAP2K4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein AAK1; TRIT1; ABCB7; MELK; SLC27A5; SCYL2; ADCY3; TNNI3K; ATP6V1A; RAD51
Function protein binding
Related Protein TMEM147; FRA10AC1; NFKBIA; APC; RPL28; LIMD1; ACTG1; PDZD11; FANCF; LBH
Function protein kinase activity
Related Protein MAP4K6; GUCY2F; MAP2K5; STK30; SBK1; RASSF2; CAMKK1B; PRKDC; MAP2K2B; PRPF4B
Function protein serine/threonine kinase activity
Related Protein ZAK; DYRK2; TSSK5; PKMYT1; CSNK1G2; PRKCA; CSNK2A2; TESK2; GM711; GRK7B
Function protein tyrosine kinase activity
Related Protein FGFR1OP; ABL2; EK1; CLK4; LCK; FGFR1A; KIT; EPHB2; MAP2K5; ABL1

Interacting Protein

MAP2K4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K4.
MAP3K1; ARRB2; MAPK8; ARRB1; CFLAR; yopP; Arrb2; TRIB1; FBP2; ALDOB; MAPK9; STX17; CYLC2; RBBP8; pi3p; npm_alk