Recombinant Mouse MAP2K4 Protein (2-397 aa), His-SUMO-tagged MAP2K4-641M

Recombinant Mouse MAP2K4 Protein (2-397 aa), His-SUMO-tagged

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Recombinant Mouse MAP2K4 Protein (2-397 aa), His-SUMO-tagged

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Cat.No. : MAP2K4-641M Optional Service: Optional requirements on this protein
Product Overview : Recombinant Mouse MAP2K4 Protein (2-397 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Protein Description: Full Length of Mature Protein.
Description : Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 ses to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Source : E. coli
Species : Mouse
Tag : His-SUMO
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 60.0 kDa
Protein length : 2-397 aa
AA Sequence : AAPSPSGGGG SGGGGGTPGP IGPPASGHPA VSSMQGKRKA LKLNFANPPV KSTARFTLNP NTTGVQNPHI ERLRTHSIES SGKLKISPEQ HWDFTAEDLK DLGEIGRGAY GSVNKMVHKP SGQIMAVKRI RSTVDEKEQK QLLMDLDVVM RSSDCPYIVQ FYGALFREGD CWICMELMST SFDKFYKYVY SVLDDVIPEE ILGKITLATV KALNHLKENL KIIHRDIKPS NILLDRSGNI KLCDFGISGQ LVDSIAKTRD AGCRPYMAPE RIDPSASRQG YDVRSDVWSL GITLYELATG RFPYPKWNSV FDQLTQVVKG DPPQLSNSEE REFSPSFINF VNLCLTKDES KRPKYKELLK HPFILMYEER TVEVACYVCK ILDQMPATPS SPMYVD
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : Map2k4 mitogen-activated protein kinase kinase 4 [ Mus musculus ]
Official Symbol : MAP2K4
Synonyms : MAP2K4; MEK 4; JNKK 1; MAPKK 4; JNK kinase 1; MEK4; MKK4; Sek1; JNKK1; Serk1; PRKMK4;
Gene ID : 26398
mRNA Refseq : NM_009157
Protein Refseq : NP_033183
UniProt ID : P47809
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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