Recombinant Human MAP2K4 Protein, His (Fc)-Avi-tagged

• Cat.No.: MAP2K4-1354H
• Product Overview: Recombinant Human MAP2K4 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Human
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: MAP2K4 mitogen-activated protein kinase kinase 4 [ Homo sapiens (human) ]
• Official Symbol: MAP2K4
• Synonyms: JNKK; MEK4; MKK4; SEK1; SKK1; JNKK1; SERK1; MAPKK4; PRKMK4; SAPKK1; SAPKK-1
• Gene ID: 6416
• mRNA Refseq: NM_003010.4
• Protein Refseq: NP_003001.1
• MIM: 601335
• UniProt ID: P45985

Reviews

10/25/2021

Good value, high quality.

04/03/2021

Pure product, no issues.

03/13/2021

Reliable, worked as described.

Q&As

Are there existing or potential therapeutic strategies targeting MAP2K4?

Targeting MAP2K4 may provide therapeutic benefits in cancer, modulating cell survival and response to stress.

What role does MAP2K4 play in cellular stress response?

MAP2K4 helps cells respond to stress, modulating survival and death pathways.

How is MAP2K4 implicated in cancer development and progression?

Dysregulation of MAP2K4 has been linked to cancer, affecting cell growth and resistance to apoptosis.

How does MAP2K4 contribute to the JNK and p38 MAPK pathways?

It phosphorylates and activates JNK and p38, transmitting signals in response to stress.

How is the activity of MAP2K4 regulated within cells?

Its activity is regulated by phosphorylation and interaction with other signaling proteins.

In which cellular processes is MAP2K4 involved?

MAP2K4 is involved in processes like cell growth, apoptosis, and stress response.

What is the primary biological function of MAP2K4 in cellular signaling?

MAP2K4 is a kinase that plays a critical role in activating the JNK and p38 MAPK signaling pathways.