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Recombinant Human MAP2K4 Protein, GST-tagged

Cat.No. : MAP2K4-17H
Product Overview : Recombinant human MEK4 (33-end) was expressed in E. coli cells using an N-terminal GST tag.
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Description : MEK4 is a member of the mitogen-activated protein kinase family and is involved in the stress-activated protein kinase pathway where it phosphorylates c-Jun NH2-terminal kinase. MEK4 is part of a signaling system that is stimulated in the presence of stress to the cell (including chemotherapy), and it controls differentiation and programmed cell death (apoptosis). MEK4 is central component of signal transduction pathways induced by mitogens and stresses. MEK4 genetic inactivation has been observed in a subset of pancreatic carcinomas, implicating deregulation of the stress-activated protein kinase pathway in pancreatic carcinogenesis.
Source : E.coli
Species : Human
Tag : GST
Molecular Mass : 63 kDa
Purity : The purity was determined to be >95% by densitometry.
Applications : Kinase Assay, Western Blot
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 μg/μL
Storage Buffer : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Shipping : One year at -70 centigrade from date of shipment.
Gene Name : MAP2K4 mitogen-activated protein kinase kinase 4 [ Homo sapiens (human) ]
Official Symbol : MAP2K4 mitogen-activated protein kinase kinase 4 [ Homo sapiens (human) ]
Synonyms : JNKK; MEK4; JNKK1; SERK1; MAPKK4; PRKMK4; SEK1; MAP2K4; mitogen-activated protein kinase kinase 4; MKK4; SKK1; SERK1; MAPKK4; SAPKK1; SAPKK-1; dual specificity mitogen-activated protein kinase kinase 4; JNK-activated kinase 1; JNK-activating kinase 1; MAP kinase kinase 4; MAPK/ERK kinase 4; MAPKK 4; MEK 4; SAPK/ERK kinase 1; c-Jun N-terminal kinase kinase 1; stress-activated protein kinase kinase 1; EC 2.7.12.2
Gene ID : 6416
mRNA Refseq : NM_003010
Protein Refseq : NP_003001
MIM : 601335
UniProt ID : P45985

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there existing or potential therapeutic strategies targeting MAP2K4? 06/12/2022

Targeting MAP2K4 may provide therapeutic benefits in cancer, modulating cell survival and response to stress.

What role does MAP2K4 play in cellular stress response? 03/24/2022

MAP2K4 helps cells respond to stress, modulating survival and death pathways.

How is MAP2K4 implicated in cancer development and progression? 04/28/2020

Dysregulation of MAP2K4 has been linked to cancer, affecting cell growth and resistance to apoptosis.

How does MAP2K4 contribute to the JNK and p38 MAPK pathways? 02/25/2020

It phosphorylates and activates JNK and p38, transmitting signals in response to stress.

How is the activity of MAP2K4 regulated within cells? 10/29/2019

Its activity is regulated by phosphorylation and interaction with other signaling proteins.

In which cellular processes is MAP2K4 involved? 10/07/2019

MAP2K4 is involved in processes like cell growth, apoptosis, and stress response.

What is the primary biological function of MAP2K4 in cellular signaling? 11/23/2018

MAP2K4 is a kinase that plays a critical role in activating the JNK and p38 MAPK signaling pathways.

Customer Reviews (3)

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Reviews
10/25/2021

    Good value, high quality.

    04/03/2021

      Pure product, no issues.

      03/13/2021

        Reliable, worked as described.

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