map2k6
Share
  • Official Full Name
  • mitogen-activated protein kinase kinase 6
  • Background
  • MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase. MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAPK/JNK.
  • Synonyms
  • MAP2K6; mitogen-activated protein kinase kinase 6; PRKMK6; dual specificity mitogen-activated protein kinase kinase 6; MAPKK6; MEK6; MKK6; protein kinase; mitogen activated; kinase 6 (MAP kinase kinase 6); SAPKK3; MEK 6; MAPKK 6; SAPK kinase 3; MAPK/ERK k; SAPKK-3
Cat.#:MAP2K6-392HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAP2K6 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:MAP2K6-176HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K6, GST-tagged
+Inquiry
Cat.#:MAP2K6-30189THTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAP2K6
+Inquiry
Cat.#:MAP2K6-34HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated MAP2K6, His-tagged
+Inquiry
Cat.#:MAP2K6-47HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MEK6, GST-tagged
+Inquiry
Cat.#:MAP2K6-524HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MKK6, Gly & Pro tagged
+Inquiry
Cat.#:MAP2K6-525HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MKK6, Gly & Pro tagged
+Inquiry
Cat.#:MAP2K6-888HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAP2K6, His & GST tagged
+Inquiry
Cat.#:MAP2K6-97HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAP2K6, His-tagged
+Inquiry
Cat.#:MAP2K6-9503MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAP2K6 Protein
+Inquiry
Cat.#:MAP2K6-2665RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MAP2K6 Protein, His-tagged
+Inquiry
Cat.#:MAP2K6-9245ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAP2K6
+Inquiry
Cat.#:MAP2K6-001HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAP2K6 cell lysate
+Inquiry

Involved Pathway

MAP2K6 involved in several pathways and played different roles in them. We selected most pathways MAP2K6 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
TNF; PPP3CC; GRB2B; PDGFB; TAOK2; SOS1; NTF3; CACNA1H; NLK2; FGFR1A
Rap signaling pathway
RAC1; PRKCB; Fgf15; LPAR2; PLCG1; CALM4; FGFR3; PRKD2; KLK1B4; RAPGEF6
Osteoclast differentiation
IKBKG; LCK; IFNAR2; MAPK10; FCGR2B; NOX1; CYBA; LILRB4; PPP3CB; PIK3R5
Toll-like receptor signaling pathway
NFKB1; IRAK4; MAP2K6; TBK1; MAP2K3; MAPK1; IKBKB; IRAK1; NFKBIAB; AKT2L
Fc epsilon RI signaling pathway
FCER1G; MAPK10; PLA2G4A; PLA2G4C; GM-CSF; PIK3R1; PLA2G4B; GAB2; MAPK9; PIK3R5
TNF signaling pathway
CXCL2; MAP2K4; CXCL5; MMP14; MAPK10; TRAF1; PTGS2; IL15; TRAF2; FAS
Inflammatory mediator regulation of TRP channels
PIK3R1; MAP2K6; HTR2B; PTGER4; HRH1; CALML3; PRKACA; CYP2J2; PIK3CD; PIK3R3
GnRH signaling pathway
CALM2; CALM2A; PRKACBB; GNAS; PLA2G4D; CALM1; CALM4; ADCY2B; ITPR3; MMP14
Amyotrophic lateral sclerosis (ALS)
MAP2K6; GRIN2B; MAPK12; RAC1; PPP3CA; TNFRSF1B; MAPK11; CCS; TNF; NEFH
Toxoplasmosis
NOS2; MAPK11; Toxoplasma Gondii Dense Granule Protein 7; IL10RA; HLA-DQB1; HSPA6; MAPK13; BCL2L1; NFKBIA; LAMB4
Influenza A
IL6; HLA-DRB5; ACTG1; VDAC1; CPSF4; LOC100033925; CYCS; AGFG1; GSK3B; MAPK12
Epstein-Barr virus infection
MAPK12; POLR3G; MAPK11; POLR2J2; EIF2AK4; YWHAE; GTF2E1; PIK3CB; POLR2B; HLA-DRB3

Protein Function

MAP2K6 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K6 itself. We selected most functions MAP2K6 had, and list some proteins which have the same functions with MAP2K6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CDK19; ATP8A1; OAS2; PI4KA; ATP1A1B; PRKD2; ERBB3; SEPHS1; PIK3C2G; RPS6KB2
Function MAP kinase kinase activity
Related Protein ALPK2; MAP2K2A; MAPK10; MAP2K3; MAP2K2; MAP2K1; MAP3K9; MAP2K2B; MAP2K7; LRRK2
Function protein binding
Related Protein COL1A2; PBK; TBL3; APEX1; WHSC2; FBXW2; ACTR8; Fzd4; RPL7; FOXC2
Function protein kinase binding
Related Protein DLG1; SHC4; TRAP1; CCNE1; GCET2; GSK3B; MAPT; BCL2L14; B4GALT1; FBXO5
Function protein serine/threonine kinase activity
Related Protein PRKCI; CSNK1G1; ULK4; MOS; TAOK3; SGK2; TSSK3; MLKL; CSNK1G2B; DMPK
Function protein tyrosine kinase activity
Related Protein Fert2; Aatk; ZNF143B; DYRK1B; MATK; EK1; JAK2B; TTK; EPHB2; LTK

Interacting Protein

MAP2K6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K6.
GADD45A; MAP3K4; LRRK2; MAP2K3; RELA; PKN1; MAPK14; MAPK14; TAOK2; GADD45B; GADD45G; MLH1