MAP2K6 Protein, mitogen-activated protein kinase kinase 6

MAP2K6

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MAP2K6

Official Full Name mitogen-activated protein kinase kinase 6
Background MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase. MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAPK/JNK.
Synonyms MAP2K6; mitogen-activated protein kinase kinase 6; PRKMK6; dual specificity mitogen-activated protein kinase kinase 6; MAPKK6; MEK6; MKK6; protein kinase; mitogen activated; kinase 6 (MAP kinase kinase 6); SAPKK3; MEK 6; MAPKK 6; SAPK kinase 3; MAPK/ERK k; SAPKK-3
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K6-001HCL Recombinant Human MAP2K6 cell lysate Insect Cell N/A
    Human MAP2K6-176H Recombinant Human MAP2K6, GST-tagged E.coli GST
    Human MAP2K6-30189TH Recombinant Human MAP2K6 Insect Cell N/A
    Human MAP2K6-34H Recombinant human biotinylated MAP2K6, His-tagged E.coli His
    Human MAP2K6-392H Recombinant Human MAP2K6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP2K6-47H Recombinant Human MEK6, GST-tagged Sf9 Insect Cell GST
    Human MAP2K6-524H Recombinant Human MKK6, Gly & Pro tagged Insect Cell His
    Human MAP2K6-525H Recombinant Human MKK6, Gly & Pro tagged Insect Cell His
    Human MAP2K6-888H Recombinant Human MAP2K6, His & GST tagged Insect Cell His/GST
    Human MAP2K6-97H Recombinant Human MAP2K6, His-tagged Insect Cell His
    Mouse MAP2K6-9503M Recombinant Mouse MAP2K6 Protein Mammalian Cell His
    Rhesus Macaque MAP2K6-2665R Recombinant Rhesus monkey MAP2K6 Protein, His-tagged Mammalian Cell His
    Zebrafish MAP2K6-9245Z Recombinant Zebrafish MAP2K6 Mammalian Cell His

    MAP2K6 involved in several pathways and played different roles in them. We selected most pathways MAP2K6 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway IL1R2; PPM1A; GNA12; TP53; HSP70L; CACNB3; FGF6; CACNG7A; TAB2; CACNG1A
    Rap signaling pathway LPAR4; CALM4; IGF1R; PIK3R5; KLK1B4; ITGB2; FGF2; FLT4; THBS1; RASSF5
    Osteoclast differentiation LILRA3; PIK3R1; IFNAR2; NOX3; IKBKG; SQSTM1; TRAF2; IL1B; TGFB1; TAB2
    Toll-like receptor signaling pathway TBK1; RIPK1L; IRAK1; FOS; TLR2-2; MAP2K4A; IFNA14; PIK3R1; TLR1; IRF3
    Fc epsilon RI signaling pathway VAV3; FYN; PLCG2; SYK; PIK3R2; PLA2G4D; RAF1; PLA2G4F; INPP5D; MAPK13
    TNF signaling pathway RPS6KA5; CXCL10; CXCL2; MAP2K1; CXCL3; CASP8; MAGI2; MMP3; MAPK11; TRAF5
    Inflammatory mediator regulation of TRP channels PPP1CB; NGF; MAPK9; NTRK1; CYP4A12A; CALML5; PRKCD; PLCB4; CALM2; CAMK2G
    GnRH signaling pathway ADCY2B; CACNA1DA; CALM2; CALM3; HRAS; ITPR1; GNRH2; MAPK9; CALM1A; CALM
    Amyotrophic lateral sclerosis (ALS) TNF; CAT; NEFH; MAP2K6; GRIN2D; GRIN2B; RAC1; BID; BCL2L1; CYCS
    Toxoplasmosis SOCS1; TYK2; PIK3R2; TLR4; LAMA1; TGFB3; HSPA1L; HLA-DPB1; HLA-DRB3; AKT2
    Influenza A MAPK13; PRSS2; PLG; IL6; IFNA6; IFNA14; HLA-DMA; MAPK10; EIF2AK1; TNFRSF10B
    Epstein-Barr virus infection NFKBIA; POLR3C; POLR2B; BCL2; NFKB1; POLR1D; YWHAZ; XPO1; RIPK1; SPN

    MAP2K6 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K6 itself. We selected most functions MAP2K6 had, and list some proteins which have the same functions with MAP2K6. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PTK2; KIAA1804; ACVR1BA; PRPF4BA; CASKA; PKZ; PRKACB; OAS2; ABCA6; SLC22A5
    MAP kinase kinase activity MAP2K3; MAP2K1; MAP2K6; MAP2K7; MAP3K14; MAPKAPK5; LRRK2; ALPK2; MAP3K20; SBK3
    protein binding WNT11; STAT5A; HK1; GTF2H3; PROM1; SMARCC1; COIL; DUSP26; C18orf56; MYOZ1
    protein kinase binding CDK5R1; SQSTM1; FAM83D; KIF14; NIPAL1; TSKS; DNM2; MAML1; H2AFY; SPRED2
    protein serine/threonine kinase activity MAP3K14; ACVR2B; DYRK4; ACVR1B; ULK2; NLK; CDK11A; RPS6KA1; PRKACBB; CSNK2A1
    protein tyrosine kinase activity Fert2; INSRB; EPHA4A; FGFR2; PTK2; FYN; MET; TTN; PTK2AB; DYRK4

    MAP2K6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K6.

    GADD45A; MAP3K4; LRRK2; MAP2K3; RELA; PKN1; MAPK14; MAPK14; TAOK2; GADD45B; GADD45G; MLH1

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