map4k5
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  • Official Full Name
  • mitogen-activated protein kinase kinase kinase kinase 5
  • Background
  • This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
  • Synonyms
  • MAP4K5; mitogen-activated protein kinase kinase kinase kinase 5; GCKR; germinal center kinase related; KHS; KHS1; MEKKK 5; MEK kinase kinase 5; germinal center kinase-related; MAPK/ERK kinase kinase kinase 5; kinase homologous to SPS1/STE20; MAPKKKK5
Cat.#:MAP4K5-388HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAP4K5 Protein, MYC/DDK-tagged
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Cat.#:MAP4K5-375HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5, GST-tagged
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Cat.#:MAP4K5-1536HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP4K5 protein, His & T7-tagged
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Cat.#:MAP4K5-947HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAP4K5, His & GST tagged
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Cat.#:Map4k5-1537MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Map4k5 protein, His & T7-tagged
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Cat.#:MAP4K5-10282ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAP4K5
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Cat.#:MAP4K5-341HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAP4K5, GST-tagged, Active
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Cat.#:MAP4K5-631HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAP4K5 cell lysate
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Involved Pathway

MAP4K5 involved in several pathways and played different roles in them. We selected most pathways MAP4K5 participated on our site, such as Insulin Signaling, TNF receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Insulin Signaling
GRB14; MYO1C; MAPK4; STXBP4; GSK3AB; KIF5B; STXBP2; REG1A; FLOT1; MINK1
TNF receptor signaling pathway
NRK; TNIK; RFFL; MAP4K5

Protein Function

MAP4K5 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K5 itself. We selected most functions MAP4K5 had, and list some proteins which have the same functions with MAP4K5. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PNKP; BAZ1B; HSPA7; TNIK; PL10; SMC2; ACSM4; ATP2B3B; PINK1; ACTG2
Function MAP kinase kinase kinase kinase activity
Related Protein MAP4K2; MAP4K1; ALPK2; MAP4K5; MAP4K6; MAP4K3
Function protein binding
Related Protein KHDRBS1; TRPC7; PCSK9; GPX7; SIKE1; NME1; RAPGEF6; DBNDD2; SLC35A2; CDC73
Function protein kinase activity
Related Protein CLK2A; EPHB4A; FASTKD3; DCKL1B; CSNK1E; MAPKAPK2A; CSNK1DA; AKT1; STK24A; PRKCD
Function protein serine/threonine kinase activity
Related Protein ACVR1B; PAK2B; BSK146; GRK1B; MOS; DYRK2; MYLK4; SLK; PIM1; ACVRL1

Interacting Protein

MAP4K5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K5.
GRB2; CRK; abl-tide; FYN; NCK1; CRKL; HCK; SETDB1; ZNF440; COPS5; linkable pd173955 analogue; bosutinib

MAP4K5 Related Articles

Nishi, H; Maeda, N; et al. Differential regulation of epidermal growth factor receptor by hydrogen peroxide and flagellin in cultured lung alveolar epithelial cells. EUROPEAN JOURNAL OF PHARMACOLOGY 748:133-142(2015).
Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).