mapk1
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  • Official Full Name
  • mitogen-activated protein kinase 1
  • Background
  • This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
  • Synonyms
  • ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK; MAPK1; mitogen-activated protein kinase 1
Cat.#:MAPK1-2008HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK1 Protein, GST-tagged
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Cat.#:MAPK1-385HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAPK1 Protein, MYC/DDK-tagged
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Cat.#:MAPK1-26227THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK1 protein
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Cat.#:MAPK1-27HTag:His
Source (Host):E. coliSpecies:Human
Product nameBiotinylated Recombinant Human ERK2, His-tagged
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Cat.#:MAPK1-28697THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK1
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Cat.#:MAPK1-28700THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK1, His-tagged
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Cat.#:MAPK1-37HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 1
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Cat.#:MAPK1-7267HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK1, GST tagged
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Cat.#:MAPK1-918HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK1, GST-tagged
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Cat.#:Mapk1-482MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Mapk1, Gly & Pro tagged
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Cat.#:Mapk1-7394MTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Mapk1, His & GST tagged
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Cat.#:MAPK1-3571RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK1 Protein
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Cat.#:Mapk1-664RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mitogen Activated Protein Kinase 1, His-tagged
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Cat.#:MAPK1-5726CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAPK1
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Cat.#:MAPK1-9677ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK1
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Cat.#:MAPK1-308HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK1, GST-tagged, Active
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Cat.#:MAPK1-529HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated protein kinase 1, His tagged
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Cat.#:Mapk1-638MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mitogen-activated Protein Kinase 1, His-tagged
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Cat.#:MAPK1-896HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 1
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Cat.#:MAPK1-692HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK1 cell lysate
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Cat.#:MAPK1-001MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK1 cell lysate
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Involved Pathway

MAPK1 involved in several pathways and played different roles in them. We selected most pathways MAPK1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP3K4; MAPK8IP3; TGFB3; PPM1BB; RELB; PLA2G4AA; RRAS; MAPK14B; STMN1B; NTF4
ErbB signaling pathway
BADB; ERBB4A; ERBB3; PAK2; PIK3CB; NCK2; PAK4; CAMK2D2; ARAF; PAK2A
Ras signaling pathway
ANGPT1; VEGFC; FGF7; RRAS; NFKB1; PLD1; VEGFB; MAPK8; RHOA; PLA2G2F
Rap signaling pathway
SIPA1L1; GNAI2; CDC42; ITGB2L; GNAI1; CALM4; FGF16; LPAR5; Adcy4; IGF1
cGMP-PKG signaling pathway
ATP1B3; GNAI3; PPP3CB; MEF2B; PIK3CA; BAD; ATP2B1; MAPK1; PPP1CC; GNAI1
cAMP signaling pathway
CAMK2A; PPP1CB; GNAI3; PDE4B; MC2R; GRIN3A; HTR4; PLCE1; GNAS; CAMK2D
Chemokine signaling pathway
GNG11; CCL24; GRK1; CCL21B; WAS; CCL22; PIK3CA; AKT2; CCL4L1; PLCB4
HIF- signaling pathway
PIK3R2; IGF1R; IFNGR1; PIK3CB; PLCG1; ENO1; RPS6; PRKCA; PFKL; TEK
FoxO signaling pathway
SOD2; PIK3CD; FOXO1; GADD45G; S1PR4; SIRT1; GABARAPA; IL6; TGFBR1B; GRB2
Sphingolipid signaling pathway
PPP2R3C; PIK3R1; SGPP2; PPP2R5A; PPP2R5B; LOC100328615; LASS2; PPP2R5E; S1PR4; RAF1
Phospholipase D signaling pathway
PLCB2; SHC4; PLA2G4D; PPAP2B; PDGFC; PLA2G4F; DNM3; PIK3CB; GRM4; PLCB1
Oocyte meiosis
SPDYA; CPEB1B; SMC3; SKP1; PPP2R5D; SPDYB; PPP3CA; ITPR3; CALM2B; YWHAE1
mTOR signaling pathway
RRAGCA; ULK1; PRKCA; MLST8; AKT2; RPS6KA3A; AKT1S1; PRKCBA; INS; PDPK1B
PIK-Akt signaling pathway
ANGPT4; ITGAV; GNGT2; RELA; IL6R; ITGA2; EPOR; MCL1; FN1; IGF1
Adrenergic signaling in cardiomyocytes
PPP2CB; SCN1BA; AGTR1A; ATP1A1; CREB3L4; CACNA2D4; PIK3R5; CACNB4; ATP2A2; PPP1CC
Vascular smooth muscle contraction
CALM; CALD1B; PRKCH; PPP1CBL; PLA2G4A; CACNA1DA; RHOAA; CALM3B; PRKACG; ARHGEF1
Dorso-ventral axis formation
MAPK1; NOTCH2; MAP2K1; SOS1; NOTCH3; MAPK3; KRAS; GRB2A; ETV6; ETS2
TGF-beta signaling pathway
NOG2; SMAD7; CUL1B; ACVR1L; SMAD3; MYCB; ID4; SPAW; LTBP1; INHBB
Axon guidance
ARPC5; SEMA4D; CSNK2A1; JAK3; KALRN; GDNF; FES; SCN4A; SEMA5A; SEMA3C
VEGF signaling pathway
PRKCA; CDC42L; RAF1; SH2D2A; HRASA; MAPK13; MAPKAPK2A; PPP3R2; PTGS2A; PTK2
Osteoclast differentiation
PIK3CA; OSCAR; BLNK; MAPK12; MAPK3; PIK3R2; cgr2b; RELB; FCGR1; NFKB1
Focal adhesion
TNK1; FLNA; COL4A6; ELK1; ILK; FLNB; Pdgfa&Pdgfb; CAPN2A; COL1A1B; BADB
Adherens junction
ACTB1; TCF7; NLK2; WASLB; BAIAP2; SSX2IPA; EGFR; CSNK2B; PARD3; MAPK1
Gap junction
PRKACAB; ITPR3; TUBB2B; GNAI2B; MAPK1; GNAI2; EGFRA; TUBA7L; MAPK3; CX35B
Signaling pathways regulating pluripotency of stem cells
ID3; FZD2; HRAS; OTX1; WNT9B; WNT2B; PIK3R5; TBX3; ID2; PCGF1
Platelet activation
Adcy4; MAPK1; GNAI3; ITGB1; MAPK13; GP1BB; GP5; PIK3R5; P2RY12; FERMT3
Toll-like receptor signaling pathway
TLR1LB; CCL4L2; PIK3CD; IFNA2; MAP2K2B; TNF; CXCL9; MAP2K1; TMED7-TICAM2; MAP2K2A
NOD-like receptor signaling pathway
NLRC4; NFKBIAB; MAP3K7IP3; CXCL1; PSTPIP1A; MAPK11; IKBKB; CARD8; LOC100033925; SUGT1
Natural killer cell mediated cytotoxicity
KIR2DS3; ULBP2; Casp3; KLRC3; FCGR3A; PPP3CB; FCGR3B; PIK3R2; IFNA10; SYK
T cell receptor signaling pathway
PAK2; PTPRC; PLCG1; CD3D; PAK7; CD8B1; VAV3; SOS1; MAP2K7; TEC
B cell receptor signaling pathway
INPPL1; CDK4; PPP3CA; VAV2; PLEKHA2; CD19; ARPC5; SOS1; MALT1; RAP2A
Fc epsilon RI signaling pathway
KRAS; RAC2; GAB2; VAV2; PLCG1; PIK3R2; PLA2G4C; FCER1G; MAPK10; SOS1
Fc gamma R-mediated phagocytosis
MARCKS; PIK3CB; ASAP3; PLCG2; SPHK2; VASP; ARPC1A; ASAP2; VAV2; PPAP2B
TNF signaling pathway
MAPK13; PIK3R3; CXCL3; MAPK9; MAP2K1; CASP8; NFKB1; MAPK1; CREB3L1; CREB3L3
Circadian entrainment
PRKCB; GNB2; PLCB1; CALM2; GRIA2; PER3; GNB3; GNAI3; GNB4; GNB1
Long-term potentiation
GRIN2C; PPP3R2; GRIA2; MAP2K1; CAMK2D; PPP1R1A; PRKCB; RPS6KA2; PPP1CC; MAP2K2
Neurotrophin signaling pathway
CALM2; NTF3; TRAF6; MAPK13; BCL2; PIK3R5; PIK3R3; GAB1; NFKB1; BAD
Retrograde endocannabinoid signaling
GABRA3; PRKCB; NAPEPLD; GNG12; GNG10; GNG8; PLCB4; GNB4; MAPK12; GRIA2
Glutamatergic synapse
PLCB4; SLC38A1; GNGT1; GNG11; GLS2; GLS; MAPK1; PPP3R1; GNB2; PLD2
Cholinergic synapse
ACHE; CHAT; KCNQ3; KCNQ1; GNG7; PIK3R1; KCNQ4; CHRNA7; ATF4; FYN
Serotonergic synapse
GNB1; GNAS; PRKCB; BRAF; GNAI3; PLCB4; CYP4X1; GNAQ; GNAI2; GNGT2
Long-term depression
HRAS; GRM1; GNAS; GRID2; GUCY1A3; PLCB2; NRAS; PPP2R1A; MAP2K2; GUCY1B3
Regulation of actin cytoskeleton
ACTN3; PIP5KL1; DIAP1; PTK2AB; PFN3; BDKRB1; CFL2; PDGFB; SLC9A1; RRAS
Insulin signaling pathway
SREBF1; CALM1A; PHKA2; INPPL1A; GYS1; SHC1; PRKAR1B; PCK2; EIF4EA; CALM4
GnRH signaling pathway
ITPR3; MAP2K4; RAF1A; SOS1; MAP3K4; CALM1A; MAP2K2A; CAMK2G1; CALM1B; ITPR1
Progesterone-mediated oocyte maturation
RPS6KA6; CPEB2; ARAF; PGR; FZR1; AKT3A; PRKACAB; IGF1; CDK1; GNAIA
Estrogen signaling pathway
HSP90AA1; CALM1; SHC2; HSP90AB1; PIK3CD; SHC3; GABBR2; GNAI1; PIK3R1; NOS3
Melanogenesis
WNT11R; MAP2K2B; MAP2K2; FZD9B; LEF1; GNAI1; WNT5A; FZD7; PRKACA; CALML5
Prolactin signaling pathway
SRC; SOCS2; NFKB1; CSN2; GRB2; ELF5; GALT; MAP2K2; PPIB; MAPK13
Thyroid hormone signaling pathway
MED17; ATP1A2; PLCZ1; NCOR1; PIK3R1; THRB; PIK3CG; PLCB3; PLCG2; DIO1
Oxytocin signaling pathway
CD38; NFATC3; PPP3R2; CCND1; RGS2; RYR2; CACNA2D1; MYL9; RHOA; PLCB4
Type II diabetes mellitus
PRKCD; PRKCE; PIK3CA; PIK3R5; TNF; SOCS4; PKM; PIK3R3; MAPK10; PRKCZ
Aldosterone-regulated sodium reabsorption
FXYD4; PIK3CG; PIK3R5; NR3C2; MAPK3; ATP1B2; KRAS; PRKCA; KCNJ1; INSR
Alzheimers disease
HSD17B10; MAPK3; NDUFV1; NDUFV2; GNAQ; ITPR1; NCSTN; ITPR2; COX7A2L; CALML3
Prion diseases
MAPK3; PRKACG; SOD1; MAP2K1; C8G; C9; BAX; ELK1; LOC100033925; PRNP
Alcoholism
GNG4; HIST1H3H; HIST1H2BH; PDYN; GNG2; GM14483; GM14479; HIST1H4G; SHC3; HIST1H2BN
Shigellosis
VCL; MAPK9; CDC42; ELMO3; RAC1; RHOG; FBXW11; MAPK11; WASF1; MAPK12
Salmonella infection
RHOGC; ROCK2; ROCK1; PFN4; NOS2A; TJP1; ROCK2B; MAPK9; RILP; MAPK10
Pertussis
C2; IL1A; C1QC; TNF; CXCL6; Itgam&Itgb2; MAPK12; TRAF6; CALM2; CASP7
Leishmaniasis
ITGAM; MAPK3; NCF4; TGFB3; IL1B; ITGB2; IL12A; PTGS2; MAP3K7; NFKBIB
Chagas disease (American trypanosomiasis)
CXCL8; TGFB2; GNA15; TNF; MAPK1; C1QA; IL1B2; NFKB1; Il2; TGFBR2
Toxoplasmosis
ITGB1; MAP3K7; MAP2K6; BIRC2; PDPK1; TLR2; LAMB4; IL12A; TGFB2; IFNG
Tuberculosis
ATP6AP1; IRAK2; FCGR2A; CD74; RFXAP; CLEC4M; MRC1; CAMK2B; CYCS; BAD
Hepatitis C
CLDN2; IFNA14; IFNAR2; CLDN10; BRAF; IRF7; MAPK13; PPP2R1A; HRAS; CD81
Hepatitis B
IFN-a; CCND1; YWHAB; PRKCB; IFNA2; IFNA1; IFNA21; NFATC2; IFNA4; TRP53
Influenza A
MAPK12; HLA-DRB1; IFNA1; HLA-DQB1; KPNA2; IFNA13; MAPK9; EIF2AK4; Ifna15; PIK3R5
Pathways in cancer
MAPK8; COL4A1; HDAC2; FGF8; LAMB3; WNT1; ITGA2B; FGF18; GNG5; LAMB2
Viral carcinogenesis
HLA-B; CREB5; HIST3H2BB-PS; HLA-G; HIST1H2BD; KAT2B; GTF2H2; SYK; HIST1H4E; YWHAZ
Proteoglycans in cancer
ERBB2; TIMP3; NRAS; MRAS; CAV1; PLCE1; CBLB; FZD6; NANOG; Ctsl
MicroRNAs in cancer
TTC6; PLCG2; MET; BRCA1; NOTCH1; CCNE2; DDIT4; SOS1; RECK; TNN
Colorectal cancer
MSH2; PIK3R1; RAC1; BAD; TP53; PIK3R2; DCC; SMAD3; MAPK8; PIK3CD
Renal cell carcinoma
AKT2; AKT1; KRAS; EP300; PIK3R2; HIF1A; PAK6; PAK2; SLC2A1; FH1
Pancreatic cancer
TP53; MAPK1; RAC2; SMAD3; ERBB2; KRAS; IKBKG; VEGFA; PIK3R2; PIK3R1
Endometrial cancer
MAP2K2; AXIN2; CDH1; ERBB2; PIK3R3; TCF7; BAD; ILK; ARAF; CCND1
Glioma
PDGFRB; AKT1; PTEN; PRKCG; CAMK2D; TP53; MAP2K2; MAP2K1; BRAF; CALML3
Prostate cancer
RAF1; NFKB1; PIK3CA; SMARCC2; PDGFC; NRAS; SPRY1; PIK3R2; MAPK1; HSP90AA1
Thyroid cancer
MAPK1; TP53; MAP2K2; HRAS; RXRG; NTRK1; TPR; CCDC6; KRAS; CDH1
Melanoma
PIK3R5; TRP53; AKT2; CCND1; FGF9; PTEN; CDH1; FGF4; MITF; FGF6
Bladder cancer
MDM2; DAPK2; DAPK1; THBS1; EGF; HRAS; HBEGF; MAPK1; MAPK3; UPK3A
Chronic myeloid leukemia
MAPK3; SMAD4; PIK3CA; CCND1; NFKB1; CTBP2; NRAS; CRK; NFKBIA; CBLB
Acute myeloid leukemia
PIK3R2; CEBPA; JUP; AKT3; STAT5A; PML; TCF7L2; RAF1; AKT2; MAPK1
Non-small cell lung cancer
RASSF1; MAPK3; PLCG2; RXRG; RXRA; PIK3R3; RARB; RB1; STK4; TGFA
Central carbon metabolism in cancer
PIK3CD; LDHA; SLC2A2; PFKP; TRP53; HIF1A; PGAM1; ERBB2; HK1; RET
Choline metabolism in cancer
GRB2; PIP5K1A; PIK3R5; DGKZ; PLA2G4F; RAC2; TAE1; DGKA; RAC1; PRKCA

Protein Function

MAPK1 has several biochemical functions, for example, ATP binding, DNA binding, MAP kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK1 itself. We selected most functions MAPK1 had, and list some proteins which have the same functions with MAPK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SMARCA4A; KIF3C; IKBKE; JAK2; KIF4; HELLS; STK35L; RARS; MYO7AA; ABCG2A
Function DNA binding
Related Protein THAP10; CDC5L; CREB3L3A; POLR3C; PARP2; XRCC5; ZNF683; ZFP451; E4F1; TADA2A
Function MAP kinase activity
Related Protein NLK2; MAPK3; NLK; MAPK15; MAPK1; MAPK14A; MAPK12B; MAPK4; MAPK8A; MAPK7
Function RNA polymerase II carboxy-terminal domain kinase activity
Related Protein MAPK1; CDK9; CDK13; CDK1; CDK7; CDK12; CDK8; CCNK
Function mitogen-activated protein kinase kinase kinase binding
Related Protein CDC42; TCF3; MARVELD3; CDC37; DUSP19; MAPK1; MAPK9; MAP3K11; TRAF6; MAPK8IP3
Function phosphatase binding
Related Protein MAGI2; TRPC4AP; DLG3; PPP1R27; SH3RF2; PPP1R37; PPP1R18; PPP1R35; CSRNP2; CTSC
Function phosphotyrosine binding
Related Protein CBLB; CBL; FGR; ACP2; MAPK3; PTPN3; LDLRAP1; ZAP70; GRB2; CBLC
Function protein binding
Related Protein PEBP1; PNMA1; C12orf49; MBL2; ATRX; RAD9; HAND1; PBLD; TRAF4; ARNTL1A
Function protein serine/threonine kinase activity
Related Protein SMOK2B; TAF1; CAMK1DB; CSNK1G2; CSNK1D; ROCK2B; CHEK1; OXSR1A; BMPR1AB; STK33
Function transcription factor binding
Related Protein LEF1; DOT1L; HES2; ZFPM2; DIP2C; EP300; PAX6; ATF7; HDAC3; CCND1

Interacting Protein

MAPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK1.
PTPN7; RPS6KA3; DUSP1; MAPK14

MAPK1 Related Articles

Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
Reverchon, M; Bertoldo, MJ; et al. CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species. BIOLOGY OF REPRODUCTION 90:-(2014).