mapk1
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  • Official Full Name
  • mitogen-activated protein kinase 1
  • Background
  • This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
  • Synonyms
  • ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK; MAPK1; mitogen-activated protein kinase 1
Cat.#:MAPK1-2008HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK1 Protein, GST-tagged
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Cat.#:MAPK1-385HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAPK1 Protein, MYC/DDK-tagged
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Cat.#:MAPK1-26227THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK1 protein
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Cat.#:MAPK1-27HTag:His
Source (Host):E. coliSpecies:Human
Product nameBiotinylated Recombinant Human ERK2, His-tagged
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Cat.#:MAPK1-28697THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK1
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Cat.#:MAPK1-28700THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK1, His-tagged
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Cat.#:MAPK1-37HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 1
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Cat.#:MAPK1-7267HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK1, GST tagged
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Cat.#:MAPK1-918HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK1, GST-tagged
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Cat.#:Mapk1-482MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Mapk1, Gly & Pro tagged
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Cat.#:Mapk1-7394MTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Mapk1, His & GST tagged
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Cat.#:MAPK1-3571RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK1 Protein
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Cat.#:Mapk1-664RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mitogen Activated Protein Kinase 1, His-tagged
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Cat.#:MAPK1-5726CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAPK1
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Cat.#:MAPK1-9677ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK1
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Cat.#:MAPK1-308HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK1, GST-tagged, Active
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Cat.#:MAPK1-529HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated protein kinase 1, His tagged
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Cat.#:Mapk1-638MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mitogen-activated Protein Kinase 1, His-tagged
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Cat.#:MAPK1-896HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 1
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Cat.#:MAPK1-692HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK1 cell lysate
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Cat.#:MAPK1-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK1 cell lysate
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Involved Pathway

MAPK1 involved in several pathways and played different roles in them. We selected most pathways MAPK1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPK7; FGF8; FGFR1; PPP3CC; MAPKAPK3; PPP3R1; MAPKAPK2A; FGFR1A; MAP3K1; TAB2
ErbB signaling pathway
PRKCB; RAF1B; SHC3; PTK2AA; PAK6B; CBL; ERBB2; CAMK2A; PLCG1; STAT5A
Ras signaling pathway
CALM4; PLA2G1B; RAF1; GRIN2B; RALB; CALM1; ABL2; GNB2; PLA2G4C; FGFR2
Rap signaling pathway
LPAR2; FGF22; SRC; INS1; FGF9; DOCK4; ITGB2L; TEK; KIT; PRKD2
cGMP-PKG signaling pathway
BDKRB2; PLCB1; AKT1; PPP1CA; NFATC1; PDE3B; ATP2A1; GUCY1B3; NFATC2; ATP2A3
cAMP signaling pathway
PTGER3; ATP1A4; PAK1; PPP1R12A; ATP1A1; MAPK10; ACOX1; HHIP; CALM1; PIK3R5
Chemokine signaling pathway
GNAI2; ITK; CCL6; PARD3; CCL21; PIK3CA; WASL; CXCR4; CCL20; ADRBK1
HIF- signaling pathway
ENO2; MTOR; EIF4E2; PIK3R5; HIF1A; ANGPT2; HMOX1; TIMP1; TFRC; PIK3R2
FoxO signaling pathway
IKBKB; MAP2K2; GRB2; FOXO3; KLF2A; MAPK8A; IRS2; IGF1RB; PRKAG3; FOXO1A
Sphingolipid signaling pathway
PRKCA; FCER1G; GAB2; NOS3; BID; RELA; RAC1; PPP2R2B; PDPK1; SPTLC1
Phospholipase D signaling pathway
SHC1; PLCG2; PLD1; SHC3; KIT; TSC1; GNA12; RHOA; IL-8; Adcy4
Oocyte meiosis
RPS6KA3A; SPDYB; CALM2; RPS6KA2; PPP2R5A; RPS6KA3B; BTRC; CAMK2D; PPP3CCB; PPP3R1
mTOR signaling pathway
RRAGC; RPS6KB1; POLDIP3; RPS6KA3; EIF4EA; DDIT4; STRADA; TSC1B; PIK3R2; PRKCBB
PIK-Akt signaling pathway
ITGB5; PPP2CA; TNC; EIF4E2; IRS1; LPAR3; LPAR6; G6PC; PPP2R2D; CCND2
Adrenergic signaling in cardiomyocytes
TPM3; MAPK14A; AGTR2; TPM2; PPP1CAB; CACNG2; PPP2R5D; PIK3R3; RYR2; PPP2CA
Vascular smooth muscle contraction
CACNA1D; CALM3; PPP1CAA; ROCK2B; CALM1B; RHOA; PPP1R12B; ADORA2AB; GNA15.4; CYP4A10
Dorso-ventral axis formation
ETS2; NOTCH4; NOTCH1A; NOTCH1B; NOTCH3; CPEB4; PIWIL1; CPEB1A; ETS1; CPEB3
TGF-beta signaling pathway
BMPR2B; E2F5; BMP4; SMAD1; ROCK2B; NDR1; NOG; NBL1; EP300; BMP5
Axon guidance
RND1L; SCN3A; CDK5; EFNB3B; SEMA3AB; CSF2; DPYSL5; NTN1; ADAM10; NEFLB
VEGF signaling pathway
MAPK12; MAPK3; PIK3CD; PPP3R2; VEGFAA; PIK3CA; NRAS; MAPK14A; PIK3R2; RAC1
Osteoclast differentiation
PIK3CA; LCP2; BLNK; GRB2; IL1B; LILRA5; TGFB1; IL1A; STAT2; NCF1
Focal adhesion
PIK3CD; PRKCBA; ELK1; GRB2B; BIRC2; PIK3CB; MYL12.1; THBS3A; FLT4; PPP1CBL
Adherens junction
RHOAC; EP300; LEF1; FER; SMAD4; NLK; RHOAD; SMAD3A; Fert2; SMAD2
Gap junction
PDGFRA; PLCB2; EGFRA; GJD2; GNAI3; CSNK1DB; DRD1B; GNAI1; TUBA2; Pdgfa&Pdgfb
Signaling pathways regulating pluripotency of stem cells
SMAD2; POU5F1; PIK3R3; MAPK13; IL6ST; PIK3R2; ACVR1B; ACVR2B; SMAD3; WNT8A
Platelet activation
PIK3R1; MYLK4; PIK3CD; GNAI3; GNAI2; ITPR1; AKT1; PPP1CC; SNAP23; PRKACA
Toll-like receptor signaling pathway
LBP; IRF7; PIK3CG; CD86; MAP2K2; IFNA21; TLR7; CXCL10; RELA; TLR8
NOD-like receptor signaling pathway
MAPK9; HSP90AA1.1; NFKBIB; NLRP3; RELA; CARD9; CXCL1; NFKBIAB; IKBKB; TNFAIP3
Natural killer cell mediated cytotoxicity
FCGR3B; ITGB2L; ULBP2; Fasl; PIK3R1; PRKCG; KLRC3; KIR2DL4; TNFRSF10B; FAS
T cell receptor signaling pathway
KRAS; PPP3R2; SLA1; MUC1; CARD11; PAK7; CBLC; CD3E; CD3D; PTPRC; PPP3R1
B cell receptor signaling pathway
ARPC1B; ARPC3; MALT1; NFKBIE; PDK2B; ITK; IFITM1; ARPC2; CSK; BCL2L11
Fc epsilon RI signaling pathway
FCER1G; AKT1; SYK; MAP2K4; GRB2; MAPK11; PIK3CA; MS4A2; MAPK1; HRAS
Fc gamma R-mediated phagocytosis
FCGR3A; FCGR2B; VAV3; WAS; RAC1; PLD1; MAP2K1; CFL2; WASL; PIK3CA
TNF signaling pathway
MAP3K7IP3; CREB3L2; MAPK1; NFKBIA; LIF; BAG4; CCL5; PIK3CA; CASP10; LTA
Circadian entrainment
GNB4; KCNJ6; GNGT2; GNB3; ITPR3; GRIA3; CALML5; GNG11; GRIN2C; CALM3
Long-term potentiation
MAPK3; MAPK1; RAP1B; PLCB1; HRAS; PPP1R1A; CAMK2D; RPS6KA1; GNAQ; PLCB4
Neurotrophin signaling pathway
PIK3R3; KIDINS220; NTRK3; MATK; HRAS; MAPK12; NRAS; RPS6KA6; ARHGDIB; BAD
Retrograde endocannabinoid signaling
GNG2; GNGT1; SLC17A6; GNB2; GNB4; DAGLB; GNG7; GNAQ; GNG10; MAPK11
Glutamatergic synapse
GNAI2; GNG7; GNB3; GRM1; GRIK5; SHANK2; GNAI1; ITPR3; PPP3CC; GRIN2B
Cholinergic synapse
SLC5A7; PIK3R2; KCNQ2; CHRM1; CHRM3; PLCB1; PRKCA; NRAS; KCNQ4; CHRNA7
Serotonergic synapse
GNAS; GNB1; APP; GNG4; ALOX12; GNAI3; PLCB1; GNG10; PRKCB; TPH1
Long-term depression
PPP1R17; PLCB4; GNAI1; GNAS; HRAS; GNAO1; CRH; GRID2; PLA2G4C; PLA2G4A
Regulation of actin cytoskeleton
ITGA11A; PIP5K1A; RAF1; SSH1; ACTN3B; GIT1; ARHGEF7A; PDGFRA; LIMK1A; ITGB2L
Insulin signaling pathway
MKNK2B; RPTOR; FBP1A; PDPK1B; INPPL1; INSB; PRKAB1B; CALM2B; PRKAG3; PRKAB1
GnRH signaling pathway
NRAS; MAPK13; CALML5; GNAS; MAP2K1; PLA2G4C; PLCB2; PLCB3; LHB; MAPK9
Progesterone-mediated oocyte maturation
MAPK8A; MAPK3; SPDYB; AKT2; CDC27; IGF1RA; MAD1L1; MAPK14B; PIK3R3; PIK3R3A
Estrogen signaling pathway
PRKCD; CREB3L3; ATF6B; PIK3R2; PLCB4; PIK3CD; RAF1; KCNJ3; SP1; MAP2K2
Melanogenesis
WNT3A; DVL3A; Adcy4; PRKCA; POMC; RAF1; CALM3A; MAP2K1; WNT11; KITA
Prolactin signaling pathway
PPIB; SOCS1; ELF5; LHB; STAT5A; PIK3CA; PIK3CG; TH; PRP2; LHCGR
Thyroid hormone signaling pathway
PIK3CB; PLCB3; KRAS; KAT2A; RXRB; NCOA1; NOTCH2; DIO2; MAP2K1; ACTG1
Oxytocin signaling pathway
HRAS; GUCY1B3; MAP2K2; PRKAB2; NFATC4; PIK3R2; PRKAG1; OXTR; CACNB4; RYR3
Type II diabetes mellitus
ADIPOQ; IKBKB; PIK3CD; PRKCD; INS2; MAPK1; PKLR; SOCS4; PDX1; INS1
Aldosterone-regulated sodium reabsorption
SCNN1G; PIK3R1; ATP1A2; PIK3CG; PIK3R2; ATP1A1; MAPK1; PIK3CB; KRAS; NEDD4L
Alzheimers disease
IL1B; ATP2A3; ATP5B; NDUFS1; SNCA; CASP9; COX6A2; PLCB1; NDUFA11; ATP5J
Prion diseases
IL1A; NCAM1; MAPK3; C1QA; IL1B; PRKACG; HSPA5; MAPK1; FYN; LAMC1
Alcoholism
GNG2; H2AFZ; H2AFB2; SLC18A1; KRAS; NTRK2; GRIN2A; DRD1; GNAI3; ADORA2A
Shigellosis
MAPK11; DIAPH1; MAPK12; SRC; PFN4; MAPK9; WAS; ITGA5; ARPC5L; IKBKB
Salmonella infection
ARPC4L; IL-8; ARPC5A; NFKB1; MAPK8A; CDC42L; ROCK2A; CCL3L1; TLR4BA; PFN2L
Pertussis
Hc; NOS2; NFKB1; TICAM2; MYD88; MAPK3; ITGAM; MAPK10; CFL2; IRAK1
Leishmaniasis
HLA-DRB4; ITGB1; CYBA; NFKBIA; IFNGR1; FCGR3A; STAT1; TNF; NCF1; MYD88
Chagas disease (American trypanosomiasis)
PIK3CG; PPP2R2B; MAPK13; Fasl; TGFBR2; GNAQ; IKBKB; TLR6; IL6; IRAK4
Toxoplasmosis
ITGB1; HLA-DOB; BIRC2; HLA-DRB4; IKBKB; TYK2; MAPK1; IFNGR2; IFNG; HSPA1B
Tuberculosis
IFNA21; CARD9; RFXAP; IL6; CALM3; ATP6V0C; CAMK2A; TLR1; CALML5; ATP6V0A4
Hepatitis C
PIK3CA; Ifna15; CLDN6; PIK3CG; IFN-a; NRAS; IFNA12; OCLN; IFNA7; IFNA10
Hepatitis B
ATP6AP1; MAPK8; NFATC1; CREB3L2; GRB2; RB1; MAP2K4; DDB2; TNF; IL6
Influenza A
RAF1; FAS; MAPK3; IRF9; MAP2K7; CXCL8; IL12B; NFKBIA; IL18; CASP9
Pathways in cancer
LAMA4; GNB2; ARHGEF12; Pdgfa&Pdgfb; FZD3; WNT2B; RXRB; PLD1; GNG7; Adcy4
Viral carcinogenesis
ATP6V0D1; RELA; HDAC11; HIST1H4C; HDAC4; HDAC3; HIST1H2BM; YWHAH; MAPKAPK2; HIST1H4M
Proteoglycans in cancer
NANOG; CAMK2G; PAK1; MAPK13; FAS; RPS6; ITGA5; IGF1R; WNT3; FGFR1
MicroRNAs in cancer
MDM2; ST14; NOTCH3; WNT3A; HMGA2; SERPINB5; FOXP1; SHC1; PRKCG; SIRT1
Colorectal cancer
TRP53; TGFB3; PIK3CD; RALGDS; Casp3; RAC2; TGFB2; PIK3CB; DCC; FOS
Renal cell carcinoma
ARNT; VEGFA; MAPK1; PIK3R1; PAK2; PAK3; PIK3R5; VHL; KRAS; CUL2
Pancreatic cancer
TGFB2; BRCA2; AKT1; TGFB3; SMAD3; MAPK3; ARAF; MAPK1; TGFBR2; PIK3R5
Endometrial cancer
PDPK1; AXIN2; CTNNA3; CCND1; MAP2K1; PIK3R5; RAF1; SOS1; CDH1; CTNNA2
Glioma
PIK3R1; AKT2; PIK3CA; MAP2K2; SHC3; PIK3R5; IGF1R; KRAS; CALML5; CAMK2A
Prostate cancer
NKX3; CREB3L1; MAP2K2; GRB2; TCF7; MAP4K1; SMARCA4; IKBKB; Ar; FGFR2
Thyroid cancer
RXRB; MAPK1; RXRG; MAP2K1; NRAS; NCOA4; CDH1; CCND1; MAPK3; BRAF
Melanoma
RB1; PTEN; HGF; HRAS; PDGFA; PDGFD; FGF13; PDGFRA; FGF5; MAPK3
Bladder cancer
E2F3; RAF1; DAPK2; MMP1; CXCL8; MMP1A; ARAF; HBEGF; RPS6KA5; ERBB2
Chronic myeloid leukemia
MAP2K1; BCL2L1; ABL1; PIK3R2; CRKL; MAPK1; PIK3CA; RAF1; MDM2; SHC4
Acute myeloid leukemia
MAP2K1; MTOR; AKT3; STAT5A; MAPK1; ZBTB16; PIM2; CCNA1; NRAS; GRB2
Non-small cell lung cancer
RAF1; PIK3R1; PRKCA; PIK3R3; AKT1; ERBB2; FOXO3; TP53; CCND1; STK4
Central carbon metabolism in cancer
PGAM1; SCO2; NTRK1; MET; PIK3R3; PIK3R1; GLS2; SIRT6; SLC2A2; MAP2K2
Choline metabolism in cancer
RPS6KB2; PLA2G4B; WASF2; LYPLA1; SLC44A1; DGKE; SLC22A5; PIK3R3; SLC44A2; PLCG1

Protein Function

MAPK1 has several biochemical functions, for example, ATP binding, DNA binding, MAP kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK1 itself. We selected most functions MAPK1 had, and list some proteins which have the same functions with MAPK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TRPV4; GSS; ATP1A1A.3; HSPA4L; ABCC10; CDK8; PFKMB; PRKCB; TTBK2; DHX35
Function DNA binding
Related Protein HIVEP3; PAX3A; BEND5; ZNF614; TSG101; NKX2-1; LHFP; ZNF620; TSNAX; BHLHA15
Function MAP kinase activity
Related Protein MAPK14; MAPK1; MAPK12B; MAPK12A; MAPK14A; NLK2; NLK; MAPK13; MAPK3; MAPK8A
Function RNA polymerase II carboxy-terminal domain kinase activity
Related Protein CDK13; CDK7; CCNK; CDK9; CDK8; CDK12; CDK1; MAPK1
Function mitogen-activated protein kinase kinase kinase binding
Related Protein STK38; MAPK8IP3; TRAF6; TRAF2; CDC37; MAP2K1; MARVELD3; MAPK1; TCF3; MAP4K2
Function phosphatase binding
Related Protein SH3YL1; SH3RF2; DLG3; CARHSP1; CHCHD3; MAPK3; PPP1R21; CRY2; PPARA; CNST
Function phosphotyrosine binding
Related Protein CBL; MAPK1; FGR; PTPN3; ACP2; STAP1; LDLRAP1; CBLC; SAMSN1; SHC1
Function protein binding
Related Protein CALM1; VPS26A; PPP4C; ANKRD27; RRAGC; OAZ1; SLC9A3R2; SSX2; EPC1; CREBBP
Function protein serine/threonine kinase activity
Related Protein CDK11A; HIPK1; STK4; PRKCA; MASTL; PKN1; WNK1; PLK1; MAPK14A; STK3
Function transcription factor binding
Related Protein IRF4; KCTD1; CREG1; PPID; GATA3; HDAC4; MDFI; HOXA7; SIRT2; ADD1

Interacting Protein

MAPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK1.
PTPN7; RPS6KA3; DUSP1; MAPK14

MAPK1 Related Articles

Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
Reverchon, M; Bertoldo, MJ; et al. CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species. BIOLOGY OF REPRODUCTION 90:-(2014).