MAPK1

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MAPK1

Official Full Name mitogen-activated protein kinase 1
Background This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Synonyms ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK; MAPK1; mitogen-activated protein kinase 1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK1-048H Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MAPK1-052H Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MAPK1-2008H Recombinant Human MAPK1 Protein, GST-tagged E.coli GST
    Mouse Mapk1-3937M Recombinant Mouse Mapk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human MAPK1-26227TH Recombinant Human MAPK1 protein E.coli N/A
    Human MAPK1-27H Biotinylated Recombinant Human ERK2, His-tagged E.coli His
    Human MAPK1-28697TH Recombinant Human MAPK1 E.coli N/A
    Human MAPK1-28700TH Recombinant Human MAPK1, His-tagged E.coli His
    Human MAPK1-308H Recombinant Human MAPK1, GST-tagged, Active E.coli GST
    Human MAPK1-37H Recombinant Human Mitogen-Activated Protein Kinase 1 E.coli N/A
    Human MAPK1-385H Recombinant Human MAPK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAPK1-529H Recombinant Human Mitogen-activated protein kinase 1, His tagged E.coli His
    Human MAPK1-692HCL Recombinant Human MAPK1 cell lysate Insect Cell N/A
    Human MAPK1-7267H Recombinant Human MAPK1, GST tagged Insect Cell GST
    Human MAPK1-896H Recombinant Human Mitogen-Activated Protein Kinase 1 Human N/A
    Human MAPK1-918H Recombinant Human MAPK1, GST-tagged Insect Cell GST
    Mouse MAPK1-001MCL Recombinant Mouse MAPK1 cell lysate Insect Cell N/A
    Mouse Mapk1-482M Recombinant Mouse Mapk1, Gly & Pro tagged Insect Cell His
    Mouse Mapk1-638M Recombinant Mouse Mitogen-activated Protein Kinase 1, His-tagged E.coli His
    Mouse Mapk1-7394M Recombinant Mouse Mapk1, His & GST tagged Insect Cell His/GST
    Rat MAPK1-3571R Recombinant Rat MAPK1 Protein Mammalian Cell His
    Rat Mapk1-664R Recombinant Rat Mitogen Activated Protein Kinase 1, His-tagged E.coli His
    Chicken MAPK1-5726C Recombinant Chicken MAPK1 Mammalian Cell His
    Zebrafish MAPK1-9677Z Recombinant Zebrafish MAPK1 Mammalian Cell His

    MAPK1 involved in several pathways and played different roles in them. We selected most pathways MAPK1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PPM1A; CACNA1B; IL1R1; MAP2K4; MAP2K6; NFKB1; RAF1; PPP3R2; FGF20B; RAC3B
    ErbB signaling pathway ERBB4A; MTOR; MYCB; KRAS; EGFRA; SHC3; PIK3R3A; MAP2K2B; AKT3A; PTK2AA
    Ras signaling pathway SHC4; MRAS; FGF11; PTPN11; PLA2G6; GNG3; GAB1; INS2; PLD1; RAP1B
    Rap signaling pathway Adcy4; MAGI1; MAP2K3; KITLG; GNAI1; PRKCZ; FGF9; APBB1IP; PFN3; ITGB1
    cGMP-PKG signaling pathway PPP1R12A; PIK3CB; CREB3L3; SRF; PLCB2; ATP1B3; ATP2A1; IRS2; CALM2; AKT1
    cAMP signaling pathway HTR4; GPR81; VAV3; ATP1A1; HCAR3; DRD1A; ACOX1; GRIN3B; GIPR; CALM3
    Chemokine signaling pathway CXCR4; CXCL10; GNAI1; GNG5; HCK; PIK3R2; AMCF-II; CDC42; CCR5; ARRB1
    HIF- signaling pathway ENO3; RBX1; IL6R; HKDC1; TIMP1; IGF1; TEK; IFNGR1; NPPA; PFKL
    FoxO signaling pathway GADD45BB; HRASB; MAP2K2; FBXO25; CCNB3; PCK1; IRS2; CDKN1BA; TGFB1; SMAD3
    Sphingolipid signaling pathway S1PR2; ASAH2; BAX; CERS5; MAPK9; CERS4; MAPK13; SPHK2; NOS3; MAPK1
    Phospholipase D signaling pathway PLD1; SHC1; LPAR3; PIK3CD; PIP5K1A; PDGFRA; PLA2G4D; PLA2G4F; PIK3CB; GRM8
    Oocyte meiosis IGF1; YWHAE1; CUL1A; SMC3; CCNB1; ANAPC1; PRKACBB; ESPL1; CALM3; RPS6KA2
    mTOR signaling pathway PDPK1B; VEGFAB; PRKCG; AKT2; EIF4E2; RPS6KA2; PIK3CD; INSB; CAB39L; RPS6KAL
    PIK-Akt signaling pathway THBS2; IFNA8; GNG13; PDGFRA; IFNA2; CCNE1; SPP1; IBSP; IL6R; THBS1
    Adrenergic signaling in cardiomyocytes ATP2B1; CACNG6; PRKACAB; TPM4B; CACNB3A; ADCY8; TNNC1; MYL3; ATP1A2A; CALM4
    Vascular smooth muscle contraction ADCY1B; MYLK; PRKG1A; MYL6; PRKACAA; PLA2G10; CALM2; GNA13A; PRKCD; GNA11B
    Dorso-ventral axis formation CPEB1B; FMN2; CPEB4; PPP1R2P9; CPEB1; GRB2B; GRB2A; ETV7; NOTCH2; KRAS
    TGF-beta signaling pathway RHOAB; SMURF2; LEFTY1; LFT1; E2F5; RPS6KB2; TGFB1A; SMAD7; PPP2CB; ACVR1L
    Axon guidance CSF2; DPYSL3; DOCK1; EPHB4; CNTN1; CAP1; NFATC3; EPHA7; NFATC2; COL6A2
    VEGF signaling pathway PPP3CCB; PIK3R3A; PLA2G4AA; PTGS2A; PIK3CA; MAPKAPK2; MAPK12B; VEGFAA; CDC42; PTK2AA
    Osteoclast differentiation PPARG; STAT1; CSF1R; LILRB1; MITF; SIRPG; LCP2; AKT1; ITGB3; TRAF2
    Focal adhesion ITGA6B; FIGF; Reln; VASP; PIK3R5; FLNC; COL6A2; RAC2; CAPN2B; MYL7
    Adherens junction CTNND1; FYNB; ACTB1; CTNNA1; PVRL1; SMAD3A; EGFR; WASB; PTPN6; PTPRF
    Gap junction GNAIA; GNAQ; TUBB2; PLCB2; GJA1; MAPK7; TUBA8; GNAI2B; HRASA; GNAS
    Signaling pathways regulating pluripotency of stem cells SMARCAD1; MAPK11; WNT10B; ACVR2A; INHBC; APC; ONECUT1; FZD1; AKT2; WNT3A
    Platelet activation PRKG1; TBXA2R; PLA2G4A; F2R; PLA2G4C; P2RX1; PTGIR; PRKCI; ITGA2B; RHOA
    Toll-like receptor signaling pathway LBP; Ifna15; AKT3A; TLR1; MAP2K4A; TLR2-1; PIK3R1; IL6; RIPK1; CCL3L3
    NOD-like receptor signaling pathway CXCL1; MAPK12B; NLRP1; NAIP6; PSTPIP1; IL1B; CXCL8B.3; CCL2; NLRC4; CARD8
    Natural killer cell mediated cytotoxicity PPP3R1; IFNA4; KIR3DL1; FASLG; SHC2; PIK3R1; ITGAL; FAS; PLCG2; PIK3R2
    T cell receptor signaling pathway PTPRC; TEC; HRAS; CBL; FYN; RELA; PAK2; CD28; PIK3R2; CBLB
    B cell receptor signaling pathway ACTR2; NFATC1; NFATC3; LCP2A; NFKB1; DOK1B; RAC1; RAC3; PPP3R2; VAV2
    Fc epsilon RI signaling pathway VAV2; MS4A2; MAPK1; FYN; RAC3; PIK3R3; BTK; PIK3CG; INPP5D; IL4
    Fc gamma R-mediated phagocytosis PLD2; PRKCD; PIP5K1A; PIK3CG; VASP; LYN; NCF1; PPAP2B; CDC42; WAS
    TNF signaling pathway FOS; CREB5; PIK3R1; RELA; SOCS3; ITCH; NFKBIA; AKT1; LIF; CXCL5
    Circadian entrainment GRIA1; GNB1; CACNA1G; KCNJ9; RYR2; GRIN2D; GNAS; PLCB2; CALML5; GNG2
    Long-term potentiation PRKCG; CAMK2D; PLCB4; MAPK3; CAMK4; PLCB3; PPP1R1A; ATF4; PPP3CA; PLCB2
    Neurotrophin signaling pathway NFKBIE; ZFP110; MAP2K7; NTRK1; CALML5; SH2B1; NRAS; TP73; GSK3B; MAP2K5
    Retrograde endocannabinoid signaling PTGS2; PLCB1; GABRA2; GNG2; MAPK10; SLC17A6; PRKCA; FAAH; GNAI1; GNAI2
    Glutamatergic synapse PPP3R2; GLS2; SLC38A3; PRKCB; SLC17A6; GNG5; GNG13; PLCB4; GRIK1; DLGAP1
    Cholinergic synapse GNG5; PIK3CB; CREB3L2; ITPR1; AKR1C1; KCNJ4; PLCB2; KCNQ2; GNB2; KCNJ6
    Serotonergic synapse GNGT2; GNG7; PLCB2; PLA2G4C; PRKCB; ARAF; MAPK3; KCNN2; HTR2C; GNG13
    Long-term depression PRKG1; PPP2CA; LYN; GNAQ; HRAS; CRHR1; IGF1R; GRIA2; PLA2G4C; GNAI3
    Regulation of actin cytoskeleton MYL7; ITGA3; APC; PIP5K1C; WASB; MYL10; RASSF7; ARHGAP35; FGFR4; FGF1
    Insulin signaling pathway INSR; PRKAB1A; MAP2K1; SOCS4; PRKAG3B; MAPK8B; PYGB; INS1; CALM1A; INS
    GnRH signaling pathway MAPK7; MAP2K2B; PTK2B; GNA11; PRKCA; MMP14A; PRKACAA; CALM1A; EGFRA; ATF4B1
    Progesterone-mediated oocyte maturation MAPK3; CCNB3; MAPK1; PRKACBA; ARAF; ADCY2B; MAD2L2; Adcy4; PIK3R5; CPEB1B
    Estrogen signaling pathway KCNJ9; PIK3CG; GNAI2; HSP90AB1; SOS1; MAPK1; FKBP5; MAP2K1; HSPA1L; GPR30
    Melanogenesis EP300; CALM2B; MAP2K2B; CALML5; WNT2; WNT7A; CAMK2G; WNT8A; WNT9A; MC1R
    Prolactin signaling pathway FOXO3; SHC2; PIK3R2; CSH; LHB; SOCS4; ELF5; PIK3CD; PIK3CB; GALT
    Thyroid hormone signaling pathway PDPK1; PLCB4; ACTG1; PLCG1; PLN; ATP1B4; PLCD1; THRB; DIO3; DIO2
    Oxytocin signaling pathway CALM4; ACTG1; RAF1; MAPK7; GNAI2; ITPR1; PPP1R12C; Adcy4; PRKAG3; RYR2
    Type II diabetes mellitus IKBKB; HK3; PIK3R1; MAPK9; SOCS2; PIK3CB; IRS4; INS1; IRS1; PRKCE
    Aldosterone-regulated sodium reabsorption PIK3CG; SCNN1G; NEDD4L; PIK3CB; SGK1; PIK3R2; SCNN1B; INSR; IRS1; FXYD2
    Alzheimers disease CHP; AKR1C1; CASP8; APBB1; CALML5; ADAM17; COX4I1; PPP3CC; mt-Atp8; GRIN2A
    Prion diseases C9; STIP1; NCAM2; C8B; C1QB; LAMC1; C8A; ELK1; IL6; PRKACB
    Alcoholism HIST3H2BB-PS; HIST1H2BF; CREB5; SHC4; HIST1H4H; HIST2H2AC; HIST1H3C; GNAI1; HIST1H2BD; HIST2H3C2
    Shigellosis PFN2; ACTG1; MAPK8; VCL; WAS; WASF1; MAPK3; NFKBIB; SRC; PFN1
    Salmonella infection WAS; CCL3L3; IL8L2; CDC42L; CXCL8B.3; MAPK12A; TLR4BA; PFN3; NOS2; TJP1
    Pertussis IL12B; C1R; NFKB1; CALM3; IL6; NOS2; Itgam&Itgb2; LY96; GNAI2; CD14
    Leishmaniasis MAPK1; IFNGR2; HLA-DOB; C3; Itgam&Itgb2; HLA-DRB4; IFNG; HLA-DQA2; CYBA; MYD88
    Chagas disease (American trypanosomiasis) C1QB; IL-8; MYD88; TGFBR2; CD247; CD3E; RELA; TNF; IKBKG; MAPK10
    Toxoplasmosis PIK3CA; LAMA2; Toxoplasma Gondii Major Surface Antigen P30; HLA-DMA; XIAP; GNAI2; CD40; CYCS; STAT3; LAMB2
    Tuberculosis VDR; ATP6V0C; RIPK2; PPP3R2; TRADD; TGFB2; SPHK1; FCGR1A; IFNA10; HLA-DQA1
    Hepatitis C TBK1; MAPK9; TRAF6; IFNA17; CLDN7; CLDN14; IFNA2; NFKB1; BRAF; IFIT1
    Hepatitis B ELK1; IFNB1; IRF7; TGFB3; PIK3CA; IFNA21; NFKBIA; PTK2B; MAP2K1; NFKB1
    Influenza A NXF3; EIF2AK2; HSPA2; HSPA1A; DDX39B; MYD88; FDPS; KPNA1; AKT2; IFNA8
    Pathways in cancer Shh; TPR; RASSF5; GNA12; TRAF4; VHL; FGFR3; MMP1; AXIN1; FOXO1
    Viral carcinogenesis HIST1H2BJ; IKBKG; CASP8; NFKB1; POLB; HLA-B; HIST1H4N; UBR4; HIST1H2BP; DDX3X
    Proteoglycans in cancer PTCH1; WNT9B; TWIST1; ITGAV; CAMK2B; FLNA; PLCG2; PAK1; DROSHA; AKT1
    MicroRNAs in cancer TP63; DNMT1; MDM2; APC; NOTCH4; PLAU; ERBB2; GRB2; NOTCH2; ATM
    Colorectal cancer TGFBR2; BRAF; PIK3CA; BAX; TGFB1; TGFB2; APPL1; PIK3CG; BIRC5; FOS
    Renal cell carcinoma TGFA; ARNT2; TGFB3; MAPK3; GAB1; BRAF; AKT1; PIK3CA; PIK3R3; TGFB2
    Pancreatic cancer TGFBR1; MAPK3; RAD51; CCND1; VEGFA; RAC2; BRAF; TGFB2; PIK3CD; TRP53
    Endometrial cancer BRAF; PIK3R5; PDPK1; APC2; PIK3R3; GRB2; CTNNA2; TCF7L2; MAP2K1; TRP53
    Glioma TGFA; PTEN; CCND1; MTOR; CALML5; KRAS; BRAF; CALM3; AKT2; PIK3R5
    Prostate cancer CREB5; PDPK1; HSP90AB1; PDGFRA; TCF7L2; Pdgfa&Pdgfb; BAD; HRAS; LEF1; PIK3R2
    Thyroid cancer PAX8; RET; RXRB; TPR; NRAS; TCF7; TRP53; MAP2K1; TP53; NTRK1
    Melanoma FGF8; ARAF; NRAS; Pdgfa&Pdgfb; FGF16; PIK3R3; BAD; PIK3R2; FGF11; CDH1
    Bladder cancer TP53; TYMP; SRC; CDKN2A; RAF1; HRAS; THBS1; IL-8; RPS6KA5; E2F2
    Chronic myeloid leukemia MDM2; AKT1; HDAC2; NFKBIA; GRB2; MAP2K2; RB1; PIK3R2; CRKL; SHC4
    Acute myeloid leukemia NFKB1; PIK3R1; IKBKG; RPS6KB2; PIK3R5; EIF4EBP1; SFPI1; ZBTB16; PML; PIM1
    Non-small cell lung cancer STK4; PIK3CB; FOXO3; HRAS; RXRB; CASP9; PDPK1; NRAS; PRKCA; EML4
    Central carbon metabolism in cancer AKT1; KRAS; FGFR2; HK3; TRP53; SLC2A2; MET; AKT2; SLC7A5; GLS
    Choline metabolism in cancer PIP5K1C; SOS1; PDGFRA; PLA2G4D; PLA2G4C; PRKCB; FOS; GRB2; PIK3R5; MAP2K1

    MAPK1 has several biochemical functions, for example, ATP binding, DNA binding, MAP kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK1 itself. We selected most functions MAPK1 had, and list some proteins which have the same functions with MAPK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding VWA8; ABCG2; IGF1RA; RPS6KB1B; SUCLG1; MKNK2B; MOK; DHX33; NPR1; GM7168
    DNA binding POLR1A; TBX3A; ZFPM1; HER6; STAT1A; ILF2; CASP8AP2; TNFAIP3; FOXI3A; MUS81
    MAP kinase activity MAPK11; MAPK12; MAPK4; MAPK8B; MAPK1; MAPK14; NLK2; MAPK12B; MAPK8A; MAPK15
    RNA polymerase II carboxy-terminal domain kinase activity CCNK; CDK1; CDK7; CDK13; MAPK1; CDK8; CDK12; CDK9
    mitogen-activated protein kinase kinase kinase binding MAPK8IP3; PPEF2; TRAF6; MAPK1; DUSP19; MAP2K1; CDC42; TCF3; MAPK9; STK38
    phosphatase binding SH3YL1; SYTL2; CARHSP1; SMAD3; PPP1R27; CTSC; SH3RF2; DLG1L; MAST2; PPP1R26
    phosphotyrosine binding SHC1; STAP1; FGR; PTPN3; SAMSN1; CBLB; MAPK3; ACP2; CBLC; CBL
    protein binding VPS11; TAB1; TSHR; UPRT; CD274; PDXP; JAKMIP2; RD3; PLEKHN1; NMUR2
    protein serine/threonine kinase activity SGK1; C9orf96; CDC42BPG; CSNK1E; NEK6; OBSCN; DYRK1A; SRPK3; TLK1B; RPS6KC1
    transcription factor binding HMGA2; THRA; HOXA7; BCL3; TCF12; HEY1; TFDP1; ID1; POU5F1; PRICKLE1

    MAPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK1.

    PTPN7; RPS6KA3; DUSP1; MAPK14

    Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
    Reverchon, M; Bertoldo, MJ; et al. CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species. BIOLOGY OF REPRODUCTION 90:-(2014).

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