mbl2
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  • Official Full Name
  • mannose-binding lectin (protein C) 2, soluble
  • Background
  • Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.
  • Synonyms
  • COLEC 1; COLEC1; Collectin-1; HSMBPC; Mannan binding lectin; Mannan binding protein; Mannan-binding protein; Mannose binding lectin (protein C)3soluble; Mannose binding lectin (protein C) 2, soluble (opsonic defect); Mannose binding lectin (protein C) 2, soluble; Mannose binding lectin3soluble; Mannose binding lectin 2, soluble (opsonic defect); Mannose binding lectin; Mannose binding lectin protein C2 soluble opsonic defect; Mannose binding protein; Mannose binding protein C; Mannose binding protein C precursor; Mannose-binding lectin; Mannose-binding protein C; MBL 2; MBL; MBL2; MBL2_HUMAN; MBL2D; MBP 1; MBP; MBP C; MBP-C; MBP1; MBPC; MGC116832; MGC116833; Opsonic defect; protein C; Soluble mannose binding lectin;
Cat.#:MBL2-1452BTag:His
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine MBL2 Protein (21-249 aa), His-tagged
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Cat.#:MBL2-1453HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human MBL2 Protein (21-248 aa), His-tagged
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Cat.#:MBL2-620HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MBL2 Protein, MYC/DDK-tagged
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Cat.#:MBL2-2329HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MBL2, His tagged
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Cat.#:MBL2-2330HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human MBL2, None tagged
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Cat.#:MBL2-233HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MBL2, His-tagged
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Cat.#:MBL2-354HTag:N/A
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human MBL2
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Cat.#:MBL2-373HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human mannose-binding lectin (protein C) 2, soluble, His-tagged
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Cat.#:MBL2-575HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MBL2 protein, His & GST-tagged
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Cat.#:MBL2-7019HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MBL2 protein, His & MBP-tagged
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Cat.#:Mbl2-7020MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mbl2 protein, His & T7-tagged
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Cat.#:Mbl2-834MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Mbl2 Protein, Fc-tagged
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Cat.#:Mbl2-835MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Mbl2 Protein, His-tagged
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Cat.#:MBL2-3603RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MBL2 Protein
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Cat.#:Mbl2-7021RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mbl2 protein, His-tagged
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Cat.#:Mbl2-7022RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mbl2 protein, His & GST-tagged
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Cat.#:MBL2-2694RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MBL2 Protein, His-tagged
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Cat.#:MBL2-5921CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MBL2
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Cat.#:MBL2-001HCLTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human MBL2 cell lysate
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Involved Pathway

MBL2 involved in several pathways and played different roles in them. We selected most pathways MBL2 participated on our site, such as Phagosome, Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
RILP; TUBA3B; ATP6V1C1B; ITGB1A; C3A.1; CTSLA; TUBA3A; THBS3A; RAC1; FCGR2A
Complement and coagulation cascades
SERPINA1D; C5; PLAT; C4BPB; PLAUR; SERPING1; C1RA; THBD; MASP1; BDKRB1
Staphylococcus aureus infection
GM5077; ITGAL; C2; PTAFR; FPR2; FCGR3B; C1RA; FCGR2A; HLA-DMB; C1QA

Protein Function

MBL2 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein binding, mannose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MBL2 itself. We selected most functions MBL2 had, and list some proteins which have the same functions with MBL2. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PPP3R2; MMP15; CDH15; MYL13; DNASE1L3; PCDHB14; CRB1; PKD2L1; FSTL4; S100A9
Function calcium-dependent protein binding
Related Protein C9orf9; MBL2; ANXA7; CLEC4M; ANXA4; MYO1D; ANXA11; S100PBP; SEC31A; CPNE3
Function mannose binding
Related Protein LMAN1; M6PR; CD209; LMAN2; Acr; LMAN2L; CD209B; MANBA; CD207; MAN2B1
Function protein binding
Related Protein SERPINB5; C9orf142; HPS4; PDE4C; FAM118A; KRT7; SLC6A12; GATA2; YBX1; PTH1R
Function receptor binding
Related Protein HSPA1B; HLA-E; SERPINE1; NMU; PVRL1; PANX1; SSTR3; HLA-A; PVRL1B; TNFSF13

Interacting Protein

MBL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBL2.
LRP1; TLR3; YBX1

MBL2 Related Articles

Pavlov, VI; Tan, YS; et al. Human Mannose-Binding Lectin Inhibitor Prevents Myocardial Injury and Arterial Thrombogenesis in a Novel Animal Model. AMERICAN JOURNAL OF PATHOLOGY 185:347-355(2015).
Soltani, A; RahmatiRad, S; et al. Polymorphisms and Serum Level of Mannose-Binding Lectin: An Iranian Survey. IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY 13:428-432(2014).