Recombinant Rat Mbl2 protein, His-tagged

• Cat.No.: Mbl2-7021R
• Product Overview: Recombinant Rat Mbl2 aa. (Glu19~Asp244) fused with N-terminal His tag was produced in E. coli cells.

Specification

• Description: A lectin that binds mannose and N-acetylglucosamine.
• Source: E. coli
• Species: Rat
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: 30kDa as determined by SDS-PAGE reducing conditions.
• Protein length: Glu19~Asp244
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 6.0.
• Applications: SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Concentration: 200ug/mL
• Storage buffer: PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300.
• Reconstitution: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Mbl2 mannose-binding lectin (protein C) 2 [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Mbl2
• Synonyms: Mbl2; mannose-binding lectin (protein C) 2; Ab2-001; Ab2-011; mannose-binding protein C; MBP-C; RA-reactive factor P28A subunit; RARF/P28A; mannan-binding protein; mannose binding lectin 2 (protein C); mannose-binding protein C (liver); ra-reactive factor polysaccharide-binding component p28A; raRF p28A
• Gene ID: 64668
• mRNA Refseq: NM_022704.2
• Protein Refseq: NP_073195.2
• UniProt ID: P08661

Reviews

09/05/2019

The use of MBL2 protein in such analyses provides valuable structural insights that contribute to the elucidation of ANO2's functional mechanisms and potential drug targeting sites.

01/28/2018

MBL2 protein has shown great utility in protein electron microscopy structure analysis.

06/06/2016

By visualizing the structural features, interactions, and conformational changes of MBL2, researchers gain valuable insights into its function and potential for therapeutic interventions.

Q&As

How does MBL2 contribute to the defense against infections?

MBL2 binds to the surface of pathogens, triggering the activation of the complement system, which leads to the destruction of the pathogens.

Can MBL2 be used as a biomarker for certain medical conditions?

Yes, altered levels of MBL2 in the blood can serve as a biomarker for certain infections and immune-related disorders.

Are there any diseases associated with MBL2 deficiencies?

Yes, MBL2 deficiencies have been linked to an increased susceptibility to various infections and autoimmune diseases.

Are there any genetic variations in the MBL2 gene?

Yes, genetic variations in the MBL2 gene can lead to variations in MBL2 protein levels and functionality.

Can MBL2 be a target for drug development?

Yes, targeting MBL2 in drug development may offer new avenues for modulating the immune response and treating infectious and autoimmune diseases.