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Recombinant Bovine MBL2 Protein (21-249 aa), His-tagged

Cat.No. : MBL2-1452B
Product Overview : Recombinant Bovine MBL2 Protein (21-249 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Full Length of Mature Protein.
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Description : Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complent pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages.
Source : Yeast
Species : Bovine
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 26.4 kDa
Protein length : 21-249 aa
AA Sequence : DTETENCENIRKTCPVIACGPPGIN GIPGKDGRDGAKGEKGEPGQGLRGS QGPPGKMGPQGTPGIPGIPGPIGQK GDPGENMGDYIRLATSERATLQSEL NQIKNWLIFSLGKRVGKKAFFTNGK KMPFNEVKTLCAQFQGRVATPMNAE ENRALKDLVTEEAFLGITDQETEGK FVDLTGKGVTYQNWNDGEPNNASPG EHCVTLLSDGTWNDIACSASFLTVC EFSL
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : MBL2 mannose binding lectin 2 [ Bos taurus (cattle) ]
Official Symbol : MBL2
Synonyms : MBL;
Gene ID : 281297
mRNA Refseq : NM_174107.2
Protein Refseq : NP_776532
UniProt ID : O02659

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does MBL2 contribute to the defense against infections? 12/21/2022

MBL2 binds to the surface of pathogens, triggering the activation of the complement system, which leads to the destruction of the pathogens.

Can MBL2 be used as a biomarker for certain medical conditions? 07/01/2022

Yes, altered levels of MBL2 in the blood can serve as a biomarker for certain infections and immune-related disorders.

Are there any diseases associated with MBL2 deficiencies? 05/20/2018

Yes, MBL2 deficiencies have been linked to an increased susceptibility to various infections and autoimmune diseases.

Are there any genetic variations in the MBL2 gene? 06/27/2017

Yes, genetic variations in the MBL2 gene can lead to variations in MBL2 protein levels and functionality.

Can MBL2 be a target for drug development? 12/03/2016

Yes, targeting MBL2 in drug development may offer new avenues for modulating the immune response and treating infectious and autoimmune diseases.

Customer Reviews (3)

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Reviews
09/05/2019

    The use of MBL2 protein in such analyses provides valuable structural insights that contribute to the elucidation of ANO2's functional mechanisms and potential drug targeting sites.

    01/28/2018

      MBL2 protein has shown great utility in protein electron microscopy structure analysis.

      06/06/2016

        By visualizing the structural features, interactions, and conformational changes of MBL2, researchers gain valuable insights into its function and potential for therapeutic interventions.

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