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MED22

  • Official Full Name

    mediator complex subunit 22

  • Overview

    This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.
  • Synonyms

    MED22; mediator complex subunit 22; SURF5, surfeit 5; mediator of RNA polymerase II transcription subunit 22; Med24; MED22_HUMAN; OTTHUMP00000022480; OTTMUSP00000012503; RGD1564893; Surf 5; Surf-5; Surfeit 5; Surfeit locus protein 5; SURF5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MED22-808H Recombinant Human MED22, GST-tagged E.coli GST 1-140aa
Human MED22-4387HCL Recombinant Human MED22 293 Cell Lysate HEK293 N/A
Human MED22-4473H Recombinant Human MED22 Protein, GST-tagged Wheat Germ GST
Human MED22-1043H Recombinant Human MED22 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MED22-3382H Recombinant Human MED22 protein, His-tagged E.coli His 1-140 aa
Human MED22-6215HF Recombinant Full Length Human MED22 Protein, GST-tagged In Vitro Cell Free System GST 140 amino acids
Mouse MED22-9694M Recombinant Mouse MED22 Protein Mammalian Cell His
Mouse Med22-4015M Recombinant Mouse Med22 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MED22-5451M Recombinant Mouse MED22 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MED22-5451M-B Recombinant Mouse MED22 Protein Pre-coupled Magnetic Beads HEK293
Rat MED22-3636R Recombinant Rat MED22 Protein Mammalian Cell His
Rat MED22-3292R Recombinant Rat MED22 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MED22-3292R-B Recombinant Rat MED22 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MED22-2721R Recombinant Rhesus monkey MED22 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MED22-2541R Recombinant Rhesus Macaque MED22 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MED22-2541R-B Recombinant Rhesus Macaque MED22 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MED22-369Z Recombinant Zebrafish MED22 Mammalian Cell His
Chicken MED22-3490C Recombinant Chicken MED22 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MED22 Related Articles

MED22 involved in several pathways and played different roles in them. We selected most pathways MED22 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Developmental BiologyLGI4;LGI2;FGF20A;FRS2B;FGF10B;GPC1B;COL6A3;ADAM23;MYOD1
Fatty acid, triacylglycerol, and ketone body metabolismAGPAT2;MED18;MED10;SLC25A1;ABCA1;ANKRD1;MED23;TMEM195;CDK19
MetabolismPEMT;CPOX;RHAG;OAZ1;PAOX;GNG13B;ALDH9A1A.2;CYP51A1;SLC52A3
Metabolism of lipids and lipoproteinsCYP2AD6;SLC27A2;GGTLC1;MTF1;THEM5;CLPS;TMEM195;SUMF2;AKR1C21
PPARA activates gene expressionMED10;MED31;MED23;MED8;MED29;TIAM2;APOA5;CTGF;MED16
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)PLIN2;MED29;MED21;MED18;MED15;MTF1;CTGF;MED6;G0S2
Transcriptional regulation of white adipocyte differentiationMED21;NR2F2;MED18;EGR2;MED22;CDK19;MED19;MED9;MED29

MED22 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED22 itself. We selected most functions MED22 had, and list some proteins which have the same functions with MED22. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription cofactor activityMED11;PPARGC1B;MED30;MED18;NKX2-5;MED19;MED21;MED19A;MED24
protein bindingTMPRSS15;TCEB3;FOXC2;BECN1;SCNN1G;RPS3A;PDHB;JAK1;C4orf46

MED22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED22 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED22.

MED10; MED29; Med30; MED19; MED27

Tebbji, F; Chen, YL; et al. A Functional Portrait of Med7 and the Mediator Complex in Candida albicans. PLOS GENETICS 10:-(2014).
Seizl, M; Lariviere, L; et al. Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization. NUCLEIC ACIDS RESEARCH 39:6291-6304(2011).
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