MED22 Protein, mediator complex subunit 22


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Official Full Name mediator complex subunit 22
Background This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.
Synonyms MED22; mediator complex subunit 22; SURF5, surfeit 5; mediator of RNA polymerase II transcription subunit 22; Med24; MED22_HUMAN; OTTHUMP00000022480; OTTMUSP00000012503; RGD1564893; Surf 5; Surf-5; Surfeit 5; Surfeit locus protein 5; SURF5
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED22-4387HCL Recombinant Human MED22 293 Cell Lysate HEK293 N/A
    Human MED22-4473H Recombinant Human MED22 Protein, GST-tagged Wheat Germ GST
    Human MED22-808H Recombinant Human MED22, GST-tagged E.coli GST
    Mouse MED22-9694M Recombinant Mouse MED22 Protein Mammalian Cell His
    Rat MED22-3636R Recombinant Rat MED22 Protein Mammalian Cell His
    Rhesus Macaque MED22-2721R Recombinant Rhesus monkey MED22 Protein, His-tagged Mammalian Cell His
    Chicken MED22-3490C Recombinant Chicken MED22 Mammalian Cell His
    Zebrafish MED22-369Z Recombinant Zebrafish MED22 Mammalian Cell His

    MED22 involved in several pathways and played different roles in them. We selected most pathways MED22 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology PEBP1; COL4A4; NTN1A; EFNB3; RASGRP1; SPTA1; ITSN1; PAQR3A; LGI3; TRIO
    Fatty acid, triacylglycerol, and ketone body metabolism MED6; MED22; CYP7A1; SREBF2; CDK19; ACOT8; MED16; ACOT12; GLIPR1; ACAD11
    Metabolism LSM1; CYP2F1; CKMB; KCNC2; CYP4B1; SLC25A1; PPM1LB; AKR1C2; DHODH; COX6A1
    Metabolism of lipids and lipoproteins SACM1L; ACOT8; CERS4A; PPM1LA; CDK19; SACM1LA; CEPT1A; APOEB; CYP2U1; DPEP1
    PPARA activates gene expression MED25; GRHL1; TIAM2; MED22; MTF1; MED8; PLIN2; MED18; MED9; MED16
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) MED7; MED19; CDK19; MED29; MED23; MED16; MTF1; ANKRD1; PLIN2; G0S2
    Transcriptional regulation of white adipocyte differentiation MED19; CDK19; EGR2; NR2F2; MED22; MED9; EBF1; MED21; MED18; MED29

    MED22 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED22 itself. We selected most functions MED22 had, and list some proteins which have the same functions with MED22. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription cofactor activity MED22; CNOT2; MED13B; PPRC1; PPARGC1B; TP53BP1; MED26; MED17; MED4; MED19A
    protein binding UHRF1; ZSCAN10; C20orf195; ING1; HTT; NPHP3; OXA1L; KIAA1191; PRKD3; RBBP5

    MED22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED22 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED22.

    MED10; MED29; Med30; MED19; MED27

    Tebbji, F; Chen, YL; et al. A Functional Portrait of Med7 and the Mediator Complex in Candida albicans. PLOS GENETICS 10:-(2014).
    Seizl, M; Lariviere, L; et al. Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization. NUCLEIC ACIDS RESEARCH 39:6291-6304(2011).

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