|Official Full Name||mediator complex subunit 22|
|Background||This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.|
|Synonyms||MED22; mediator complex subunit 22; SURF5, surfeit 5; mediator of RNA polymerase II transcription subunit 22; Med24; MED22_HUMAN; OTTHUMP00000022480; OTTMUSP00000012503; RGD1564893; Surf 5; Surf-5; Surfeit 5; Surfeit locus protein 5; SURF5|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
MED22 involved in several pathways and played different roles in them. We selected most pathways MED22 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Developmental Biology||PEBP1; COL4A4; NTN1A; EFNB3; RASGRP1; SPTA1; ITSN1; PAQR3A; LGI3; TRIO|
|Fatty acid, triacylglycerol, and ketone body metabolism||MED6; MED22; CYP7A1; SREBF2; CDK19; ACOT8; MED16; ACOT12; GLIPR1; ACAD11|
|Metabolism||LSM1; CYP2F1; CKMB; KCNC2; CYP4B1; SLC25A1; PPM1LB; AKR1C2; DHODH; COX6A1|
|Metabolism of lipids and lipoproteins||SACM1L; ACOT8; CERS4A; PPM1LA; CDK19; SACM1LA; CEPT1A; APOEB; CYP2U1; DPEP1|
|PPARA activates gene expression||MED25; GRHL1; TIAM2; MED22; MTF1; MED8; PLIN2; MED18; MED9; MED16|
|Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)||MED7; MED19; CDK19; MED29; MED23; MED16; MTF1; ANKRD1; PLIN2; G0S2|
|Transcriptional regulation of white adipocyte differentiation||MED19; CDK19; EGR2; NR2F2; MED22; MED9; EBF1; MED21; MED18; MED29|
MED22 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED22 itself. We selected most functions MED22 had, and list some proteins which have the same functions with MED22. You can find most of the proteins on our site.
|RNA polymerase II transcription cofactor activity||MED22; CNOT2; MED13B; PPRC1; PPARGC1B; TP53BP1; MED26; MED17; MED4; MED19A|
|protein binding||UHRF1; ZSCAN10; C20orf195; ING1; HTT; NPHP3; OXA1L; KIAA1191; PRKD3; RBBP5|
MED22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED22 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED22.
MED10; MED29; Med30; MED19; MED27