mmp12
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  • Official Full Name
  • matrix metallopeptidase 12 (macrophage elastase)
  • Background
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MMP12; matrix metallopeptidase 12 (macrophage elastase); ME; HME; MME; MMP-12; macrophage metalloelastase; matrix metalloproteinase 12 (macrophage elastase)
Cat.#:MMP12-1283HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP12 Protein, His-tagged
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Cat.#:MMP12-5418HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MMP12 Protein, GST-tagged
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Cat.#:MMP12-164HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP12(Macrophage Elastase), Inactive, Catalytic Domain
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Cat.#:MMP12-06HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP12 protein, His-tagged
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Cat.#:MMP12-1133HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP12, His tagged
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Cat.#:MMP12-157HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP12
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Cat.#:MMP12-158HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP12
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Cat.#:MMP12-28717THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP12, His-tagged
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Cat.#:Mmp12-533MTag:His
Source (Host):Human CellsSpecies:Mouse
Product nameRecombinant Mouse Mmp12 protein, His-tagged
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Cat.#:Mmp12-534MTag:
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Mmp12
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Cat.#:Mmp12-600MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mmp12 Protein, His-tagged
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Cat.#:MMP12-9907MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MMP12 Protein
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Cat.#:MMP12-3712RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MMP12 Protein
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Cat.#:Mmp12-602RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp12 Protein, His-tagged
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Cat.#:Mmp12-603RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp12 Protein, His-tagged
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Cat.#:Mmp12-604RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp12 Protein, His-tagged
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Cat.#:Mmp12-605RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp12 Protein, His-tagged
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Cat.#:MMP12-606RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit MMP12 Protein, His-tagged
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Cat.#:MMP12-4281HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MMP12 293 Cell Lysate
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Cat.#:CSC-P0953Tag:
Source (Host):Species:Human
Product nameAnti-Human MMP12 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0954Tag:
Source (Host):Species:Human
Product nameAnti-Human MMP12 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0955Tag:
Source (Host):Species:Human
Product nameAnti-Human MMP12 scFv Stable Cell Line-CHO
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Involved Pathway

MMP12 involved in several pathways and played different roles in them. We selected most pathways MMP12 participated on our site, such as Collagen degradation, Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP12 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Collagen degradation
COL23A1; CTSK; COL9A1; MGC174152; COL9A3; MMP15; MMP19; MMP12; ELANE; MMP20
Degradation of the extracellular matrix
ADAMTS4; CAPNS1; MMP12; COL23A1; ADAMTS8; MMP8; CTSLL; MMP10; CTSL2; CMA1
Extracellular matrix organization
TIMP2A; LRP4; PCOLCE; BSG; COL4A6; MGC174155; CD151; CTSB; EFEMP2; COL8A1A
Matrix Metalloproteinases
MMP12; MMP10; MMP20; MMP8; TIMP4; MMP27; MMP17; MMP24; MMP28; MMP23B

Protein Function

MMP12 has several biochemical functions, for example, calcium ion binding, endopeptidase activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP12 itself. We selected most functions MMP12 had, and list some proteins which have the same functions with MMP12. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein HEG; PVALB6; EPDR1; CBLC; PLSCR2; FKBP9; TBC1D8B; ANXA3B; MAN1A1; EHD2B
Function endopeptidase activity
Related Protein KLK1B8; KLK1B11; ADAMTS3; PSMA1; RHBDD1; PSMB9B; CPS1; CTSH; SENP5; TMEM59
Function metalloendopeptidase activity
Related Protein MMP3; MEP1A.2; PITRM1; C6AST4; ADAMTS4; ADAM32; ADAMTSL4; MMP19; GM12824; MEP1A.1
Function zinc ion binding
Related Protein MT1E; LIMK1A; TRIM3; CECR1A; HERC2; UBR7; LMO7A; GFI1; MORC3B; ING5B

Interacting Protein

MMP12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP12.
ELN

MMP12 Related Articles

Palacios, BS; Estrada-Capetillo, L; et al. Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile. JOURNAL OF PATHOLOGY 235:515-526(2015).
John-Schuster, G; Hager, K; et al. Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 307:L692-L706(2014).

MMP12 Related Gene Family

MMPs