Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

MMP12

  • Official Full Name

    matrix metallopeptidase 12 (macrophage elastase)

  • Overview

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
  • Synonyms

    MMP12; matrix metallopeptidase 12 (macrophage elastase); ME; HME; MME; MMP-12; macrophage metalloelastase; matrix metalloproteinase 12 (macrophage elastase);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rabbit
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Mouse myeloma cell line
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MMP12-157H Active Recombinant Human MMP12 E.coli N/A
Human MMP12-06H Recombinant Human MMP12 protein, His-tagged E.coli His
Human MMP12-164H Recombinant Human MMP12(Macrophage Elastase), Inactive, Catalytic Domain E.coli N/A
Human MMP12-1283H Recombinant Human MMP12 Protein, His-tagged E.coli His
Human MMP12-1133H Recombinant Human MMP12, His tagged Human Cell His
Human MMP12-158H Recombinant Human MMP12 E.coli N/A
Human MMP12-28717TH Recombinant Human MMP12, His-tagged E.coli His
Human MMP12-4281HCL Recombinant Human MMP12 293 Cell Lysate HEK293 N/A
Human MMP12-1134H Active Recombinant Human MMP12 Protein Mouse myeloma cell line
Human MMP12-6451HF Recombinant Full Length Human MMP12 Protein, GST-tagged In Vitro Cell Free System GST 470 amino acids
Human MMP12-3156H Recombinant Human MMP12 Protein (Ala290-Gly469), His tagged E.coli His Ala290-Gly469
Human MMP12-5418H Recombinant Human MMP12 Protein, GST-tagged Wheat Germ GST
Human MMP12-3662H Recombinant Human MMP12 protein, His-tagged E.coli His 231-402 aa
Mouse Mmp12-534M Active Recombinant Mouse Mmp12 Mammalian cells N/A
Mouse Mmp12-533M Recombinant Mouse Mmp12 protein, His-tagged Human Cell His Ala29-Cys473
Mouse MMP12-9907M Recombinant Mouse MMP12 Protein Mammalian Cell His
Mouse Mmp12-600M Recombinant Mouse Mmp12 Protein, His-tagged E.coli His Ala294~Cys473
Mouse Mmp12-5717M Recombinant Mouse Mmp12 Protein (Ala29-Cys473), C-His tagged Mammalian cells C-His Ala29-Cys473
Mouse Mmp12-10592M-B Recombinant Mouse Mmp12 Protein Pre-coupled Magnetic Beads HEK293
Mouse Mmp12-10592M Recombinant Mouse Mmp12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Mmp12-602R Recombinant Rat Mmp12 Protein, His-tagged E.coli His Val20~Arg99
Rat MMP12-3712R Recombinant Rat MMP12 Protein Mammalian Cell His
Rat Mmp12-603R Recombinant Rat Mmp12 Protein, His-tagged E.coli His Cys100~Pro286
Rat Mmp12-605R Recombinant Rat Mmp12 Protein, His-tagged E.coli His Tyr372~His463
Rat Mmp12-604R Recombinant Rat Mmp12 Protein, His-tagged E.coli His Pro270~Arg362
Rat MMP12-3368R-B Recombinant Rat MMP12 Protein Pre-coupled Magnetic Beads HEK293
Rat MMP12-01R Recombinant Rat MMP12 Protein E.coli
Rat MMP12-3368R Recombinant Rat MMP12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit MMP12-606R Recombinant Rabbit MMP12 Protein, His-tagged E.coli His Val286~Cys464
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MMP12 Related Articles
  • MMP12 Related Gene Family
  • MMP12 Related Research Area

MMP12 involved in several pathways and played different roles in them. We selected most pathways MMP12 participated on our site, such as Collagen degradation, Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Collagen degradationADAM9;MMP11;EMID2;LOC100686744;CTS7;CTSL1;MGC174857;COL19A1;MMP19
Degradation of the extracellular matrixMMP10;COL13A1;CTSD;ADAM9;CMA1;ADAM15;COL19A1;MMP13;MMP11
Extracellular matrix organizationSERPINH1A;DMD;SPARC;TTR;COL28A1A;CTSB;MFAP1B;CEACAM6;COL1A1
Matrix MetalloproteinasesMMP8;MMP19;MMP24;MMP10;MMP26;BSG;MMP11;TIMP4;MMP12

MMP12 has several biochemical functions, for example, calcium ion binding, endopeptidase activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP12 itself. We selected most functions MMP12 had, and list some proteins which have the same functions with MMP12. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingNCALD;BRAF;Npnt;SULF2B;SYT2;MGP;TTYH1;CAPN1A;CABP5
endopeptidase activityPSMB8;P4HB;PSMA4;PSMA2;KLK1B22;KLK1B24;KLK1B5;APH1C;ADAMTS3
metalloendopeptidase activityMEP1A.1;NPSN;Adamts19;MMP7;PMPCB;PAPPAB;MMP25;ADAMTS15A;MMP26
zinc ion bindingRNF32;MYNN;MMP15;UQCRC2B;MANEA;GATAD2A;TRAF4B;CLIP1;MT2A

MMP12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP12.

ELN

Palacios, BS; Estrada-Capetillo, L; et al. Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile. JOURNAL OF PATHOLOGY 235:515-526(2015).
John-Schuster, G; Hager, K; et al. Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 307:L692-L706(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All MMP12 Products

Required fields are marked with *

My Review for All MMP12 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends