msr1
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  • Official Full Name
  • macrophage scavenger receptor 1
  • Background
  • This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimers disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
  • Synonyms
  • MSR1; macrophage scavenger receptor 1; macrophage scavenger receptor types I and II; CD204; SCARA1; scavenger receptor class A member 1; scavenger receptor class A, member 1; macrophage scavenger receptor type III; macrophage acetylated LDL receptor I and; SRA; SR-A; phSR1; phSR2
Cat.#:MSR1-2026HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MSR1 Protein, His-tagged
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Cat.#:MSR1-2090HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MSR1 Protein, MYC/DDK-tagged
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Cat.#:MSR1-5664HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MSR1 Protein, GST-tagged
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Cat.#:MSR1-30164THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MSR1
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Cat.#:MSR1-44HTag:T7|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MSR1 protein, T7/His-tagged
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Cat.#:MSR1-53HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human MSR1 protein, His-tagged
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Cat.#:MSR1-743HTag:GST|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MSR1 Protein, GST-His-tagged
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Cat.#:MSR1-872HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MSR1, His tagged
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Cat.#:Msr1-171MTag:His
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Msr1, His-tagged
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Cat.#:Msr1-3275MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Msr1, His tagged
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Cat.#:Msr1-38RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Msr1, His tagged
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Cat.#:Msr1-8792RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Msr1, Fc tagged
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Cat.#:MSR1-2844HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human MSR1 cell lysate
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Cat.#:MSR1-2288MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse MSR1 cell lysate
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Cat.#:MSR1-800RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat MSR1 cell lysate
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Involved Pathway

Msr1 involved in several pathways and played different roles in them. We selected most pathways Msr1 participated on our site, such as Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Msr1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
HLA-DQA1; HLA-DPB1; RAC1; ATP6V1E1B; ATP6V0B; NOS1; ITGB1B.2; TLR4BB; HLA-F; ATP6V1D

Protein Function

Msr1 has several biochemical functions, for example, low-density lipoprotein particle binding, protein binding, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Msr1 itself. We selected most functions Msr1 had, and list some proteins which have the same functions with Msr1. You can find most of the proteins on our site.
Function
Related Protein
Function low-density lipoprotein particle binding
Related Protein COLEC12; MSR1; PCSK9; THBS1; LIPC; ANKRA2; CDH13; SORL1; SCARB1; CRP
Function protein binding
Related Protein LYSMD1; TNKS2; FGFR1; PTPN14; EDNRA; TEX13A; WDR20; MAPRE1; MFAP4; LRPAP1
Function scavenger receptor activity
Related Protein MARCO; CFI; SCARA3; GM106; PRG4A; CD163L1; POLR1B; TMPRSS2; TMPRSS4; PRSS12

Interacting Protein

Msr1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Msr1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Msr1.
ATP6V0C; MALL; NKG7; LEPROTL1; SEC22A; HOOK3; Hook3