mthfd2
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  • Official Full Name
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
  • Background
  • This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7.
  • Synonyms
  • MTHFD2; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase; bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; NAD-dependent methylene tetrahydrofolate dehydrogenase cycloh
Cat.#:MTHFD2-1868BTag:His|SUMO
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine MTHFD2 Protein (36-350 aa), His-SUMO-tagged
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Cat.#:MTHFD2-22HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human KIAA1324 Protein, His-tagged
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Cat.#:MTHFD2-136HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MTHFD2 protein, T7-tagged
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Cat.#:MTHFD2-393HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MTHFD2, T7-tagged
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Cat.#:MTHFD2-394HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MTHFD2, MYC/DDK-tagged
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Cat.#:MTHFD2-395HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MTHFD2, GST-tagged
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Cat.#:MTHFD2-571HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MTHFD2 Protein, His-tagged
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Cat.#:MTHFD2-10192MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MTHFD2 Protein
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Cat.#:MTHFD2-3013CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MTHFD2
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Cat.#:MTHFD2-400ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MTHFD2
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Cat.#:MTHFD2-4082HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MTHFD2 293 Cell Lysate
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Cat.#:MTHFD2-4083HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MTHFD2 293 Cell Lysate
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Involved Pathway

MTHFD2 involved in several pathways and played different roles in them. We selected most pathways MTHFD2 participated on our site, such as Metabolic pathways, Nucleotide Metabolism, One Carbon Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTHFD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolic pathways
HSD17B6; POLA1; PCK1; SGMS1; ATP6V1C1A; TDO2B; MAN1A1; HSD3B1; COX15; PLA2G4C
Nucleotide Metabolism
ADSS; OAZ1; MTHFD2; ADSL
One Carbon Metabolism
MTFMT; MTHFD2; FTCD; MTHFS; ST20-MTHFS; ALDH1L1; AHCY
One carbon pool by folate
MTHFS; MTHFD2L; AMT; MTHFR; MTHFD1L; TYMS; SHMT1; MTHFD2; MTFMT; SHMT2
Trans-sulfuration and one carbon metabolism
DNMT3L; MTHFD2
folate transformations I
ALDH1L1; MTHFSD; MTHFD2; ALDH1L2

Protein Function

MTHFD2 has several biochemical functions, for example, NOT formate-tetrahydrofolate ligase activity, magnesium ion binding, methenyltetrahydrofolate cyclohydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MTHFD2 itself. We selected most functions MTHFD2 had, and list some proteins which have the same functions with MTHFD2. You can find most of the proteins on our site.
Function
Related Protein
Function NOT formate-tetrahydrofolate ligase activity
Related Protein MTHFD2L; MTHFD2
Function magnesium ion binding
Related Protein FARS2; HMGCL; MAST2; NT5C3B; TDP2; PPM1BA; NT5C3A; DCTPP1; PIF1; DYRK2
Function methenyltetrahydrofolate cyclohydrolase activity
Related Protein MTHFD1B; MTHFD2; MTHFD1; MTHFD2L
Function methylenetetrahydrofolate dehydrogenase (NAD+) activity
Related Protein MTHFD2L; MTHFD2; MTHFD1
Function methylenetetrahydrofolate dehydrogenase (NADP+) activity
Related Protein MTHFD1B; MTHFD2; MTHFD2L; MTHFD1
Function phosphate ion binding
Related Protein RELA; CHST14; SLC34A2; OTC; SH2B3; PNP; MTHFD2; RPH3A; ADSSL1; G6PC

Interacting Protein

MTHFD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTHFD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTHFD2.
MCC; PSMD13; PARP3; NAGK; Nek2; nef; Lmna; LRRK2; P