muc5b
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  • Official Full Name
  • mucin 5B, oligomeric mucus/gel-forming
  • Background
  • This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases.
  • Synonyms
  • MUC5B; mucin 5B, oligomeric mucus/gel-forming; MUC5, mucin 5, subtype B, tracheobronchial; mucin-5B; MG1; tracheobronchial; Cervical mucin; Cervical mucin MUC5B; High molecular weight salivary mucin MG1; MUC-5B; MUC5; MUC5B_HUMAN; MUC9; Mucin 5 subtype B, tracheobronchial; Mucin 5B; Mucin 5B oligomeric mucus/gel forming; Mucin-5 subtype B; Sublingual gland mucin; OTTHUMP00000233052; mucin-5 subtype B, tracheobronchial; mucin 5, subtype B, tracheobronchial
Cat.#:MUC5B-1030HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MUC5B, GST-tagged
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Cat.#:MUC5B-784HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MUC5B protein, His-tagged
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Cat.#:Muc5b-785MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Muc5b protein, His-tagged
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Cat.#:Muc5b-786RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Muc5b protein, His & GST-tagged
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Cat.#:Muc5b-787RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Muc5b protein, His & GST-tagged
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Cat.#:Muc5b-788RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Muc5b protein, His & GST-tagged
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Cat.#:MUC5B-783CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle MUC5B protein, His-tagged
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Involved Pathway

MUC5B involved in several pathways and played different roles in them. We selected most pathways MUC5B participated on our site, such as Salivary secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUC5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Salivary secretion
ITPR1; PRH2; PLCB1; TRPV6; PLCB3; VAMP2; CST3; ATP1B1; AMY1A; ATP1A2

Protein Function

MUC5B has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MUC5B itself. We selected most functions MUC5B had, and list some proteins which have the same functions with MUC5B. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein PTPN2; ACY3; ALAS2; NSF; ACTR10; CIB1; TMEM8A; MIS12; CTLA4; RFX1

MUC5B Related Articles

Yunus, MHM; Siang, KC; et al. The effects of human serum to the morphology, proliferation and gene expression level of the respiratory epithelium in vitro. TISSUE & CELL 46:233-240(2014).
Henderson, AG; Ehre, C; et al. Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure. JOURNAL OF CLINICAL INVESTIGATION 124:3047-3060(2014).