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MYBPC3

  • Official Full Name

    myosin binding protein C, cardiac

  • Overview

    MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
  • Synonyms

    MYBPC3; myosin binding protein C, cardiac; FHC; CMH4; CMD1MM; LVNC10; MYBP-C; myosin-binding protein C, cardiac-type; C-protein, cardiac muscle isoform;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Yeast
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MYBPC3-8230H Recombinant Human MYBPC3 protein, His & GST-tagged E.coli His/GST Met1~Ala328 (Accession # Q14896)
Human MYBPC3-19H Recombinant Human MYBPC3 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MYBPC3-501H Recombinant Human MYBPC3 Mammalian Cell His
Human MYBPC3-1125H Recombinant Human MYBPC3, His-tagged E.coli His 1-328aa
Human MYBPC3-1289H Recombinant Human MYBPC3 Protein, His-SUMO-tagged E.coli His/SUMO
Human MYBPC3-943H Recombinant Human MYBPC3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MYBPC3-4636H Recombinant Human MYBPC3 Protein (Met1-Ala328), N-His tagged E.coli N-His Met1-Ala328
Human MYBPC3-9131HFL Recombinant Full Length Human MYBPC3 protein, Flag-tagged Mamanlian cells Flag
Human MYBPC3-3551H Recombinant Human MYBPC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MYBPC3-3551H-B Recombinant Human MYBPC3 Protein Pre-coupled Magnetic Beads HEK293
Human MYBPC3-01H Recombinant Human MYBPC3 Protein, His-Tagged E.coli His
Mouse Mybpc3-4236M Recombinant Mouse Mybpc3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat MYBPC3-3836R Recombinant Rat MYBPC3 Protein Mammalian Cell His
Rat MYBPC3-3495R Recombinant Rat MYBPC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MYBPC3-3495R-B Recombinant Rat MYBPC3 Protein Pre-coupled Magnetic Beads HEK293
Rat MYBPC3-1467R Recombinant Rat MYBPC3 Protein (645-864 aa), His-tagged Yeast His 645-864 aa
Zebrafish MYBPC3-3886Z Recombinant Zebrafish MYBPC3 Mammalian Cell His
Chicken MYBPC3-6673C Recombinant Chicken MYBPC3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MYBPC3 Related Research Area

MYBPC3 involved in several pathways and played different roles in them. We selected most pathways MYBPC3 participated on our site, such as Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), Muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYBPC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Dilated cardiomyopathyCACNG2;CACNB2;EMD;MYL3;TPM1;TGFB2;CACNG7;MYL2;ITGB7
Hypertrophic cardiomyopathy (HCM)PRKAG2;ATP2A2;ITGB3;ITGB6;Itga10&Itgb1;RYR2;ITGA2B;CACNA2D4;SLC8A1
Muscle contractionMYL6B;TNNI2A.4;SORBS3;MYL12A;DESMA;MYBPC1;DMD;MYL12B;VIML
Striated Muscle ContractionTNNI1B;TNNI2A.4;TNNI2B.2;TNNT3;CMLC1;DES;DESMB;DESMA;TNNI2A.1

MYBPC3 has several biochemical functions, for example, ATPase activator activity, actin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYBPC3 itself. We selected most functions MYBPC3 had, and list some proteins which have the same functions with MYBPC3. You can find most of the proteins on our site.

Function Related Protein
ATPase activator activityDNAJC15;AHSA1;ATP1B2;DNAJB6;DNAJC10;RAB4A;MYBPC3;AHSA2;DNAJC19
actin bindingITGB1;FMN1;MYO19;HDAC6;CAMK2B;CAPZA1A;ACTN3A;SHROOM2;AVIL
identical protein bindingSTAT2;CLDN23;TMEM173;AGXT2L1;PPP1R13L;RAD51;MYOM1;TP53;ETNPPL
metal ion bindingCACNA2D1;TRIM41;RNF144AB;CALM4;NEURL1AA;NR6A1B;GIT1;ING5A;FAM170A
myosin bindingARFGEF1;SMYD1B;ACTC1;NPHS1;USH2A;STX4A;TRIM32;DMD;MYBPC3
myosin heavy chain bindingMYL2;PDLIM2;MYL12B;MYBPC3;AMPD1;CORO1A;MYL9
protein bindingTMA16;FNDC3B;SAMHD1;PSMB10;COA6;MAP4K4;CREM;MVK;PLK4
structural constituent of muscleMYL3;ANKRD2;PLEC;MYBPC3;MYL2;MYH11;TCAP;MYL6;MYBPC1
titin bindingSLC14A2;CAMK2D;ANKRD1B;MYBPC3;ANKRD23;CALM2;ANKRD2;CAPN3;OBSCN

MYBPC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYBPC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYBPC3.

PDE4DIP; SVIL; MYZAP; CNN1; ACTB; ACTC1; FLNC; TNNI3K; SPATA20; PARD3; TRIM63; CCT7; SMURF2

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What role does MYBPC3 play in cardiac muscle contraction? 02/13/2022

It stabilizes the sarcomere and regulates the force and kinetics of muscle contraction.

What is the primary role of MYBPC3 in muscle function? 06/07/2021

MYBPC3 is critical for regulating muscle contraction and maintaining sarcomere structure.

How is MYBPC3 implicated in cardiomyopathies? 01/07/2020

Mutations and dysfunction in MYBPC3 are linked to the development of cardiomyopathies.

In which types of muscles is MYBPC3 predominantly expressed? 09/09/2019

MYBPC3 is primarily expressed in cardiac muscle.

How does MYBPC3 interact with other proteins in the sarcomere? 04/03/2019

It interacts with actin and myosin, modulating cross-bridge cycling during contraction.

Are there known genetic mutations in MYBPC3 associated with specific cardiac conditions? 01/23/2019

Numerous genetic mutations in MYBPC3 are associated with hypertrophic cardiomyopathy.

What therapeutic strategies are being explored involving MYBPC3? 01/18/2018

Therapeutic strategies include gene therapy to correct MYBPC3 mutations and manage cardiomyopathy.

Customer Reviews (3)

Write a review
Reviews
02/26/2021

    Product is reliable, effective.

    08/01/2020

      High-quality, reliable in assays.

      12/17/2018

        Fast delivery, great quality.

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