mybpc3
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  • Official Full Name
  • myosin binding protein C, cardiac
  • Background
  • MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MYBPC3; myosin binding protein C, cardiac; FHC; CMH4; CMD1MM; LVNC10; MYBP-C; myosin-binding protein C, cardiac-type; C-protein, cardiac muscle isoform;
Cat.#:MYBPC3-1467RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat MYBPC3 Protein (645-864 aa), His-tagged
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Cat.#:MYBPC3-1289HTag:His|SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYBPC3 Protein, His-SUMO-tagged
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Cat.#:MYBPC3-1125HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYBPC3, His-tagged
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Cat.#:MYBPC3-19HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MYBPC3 protein, MYC/DDK-tagged
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Cat.#:MYBPC3-501HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MYBPC3
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Cat.#:MYBPC3-8230HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYBPC3 protein, His & GST-tagged
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Cat.#:MYBPC3-3836RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MYBPC3 Protein
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Cat.#:MYBPC3-6673CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MYBPC3
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Cat.#:MYBPC3-3886ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MYBPC3
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Involved Pathway

MYBPC3 involved in several pathways and played different roles in them. We selected most pathways MYBPC3 participated on our site, such as Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), Muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYBPC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Dilated cardiomyopathy
ITGB4; CACNG3; EMD; ITGA2B; MYH7; CACNA2D1; Adcy4; TGFB1; TTN; SGCB
Hypertrophic cardiomyopathy (HCM)
ACE; ITGA7; CACNG1; TGFB2; ITGA8; DMD; CACNG6; CACNG4; CACNA2D1; TNF
Muscle contraction
MYLZ3; MYL1; TMOD2; VIML; TMOD3; TNNI2B.1; CMLC1; TNNT3B; SMYHC3; TNNI2B.2
Striated Muscle Contraction
DESMB; MYLZ3; TNNI2A.3; TNNI2A.1; TNNT1; SMYHC2; TMEM8C; ACTA1B; TNNT3A; TMOD4

Protein Function

MYBPC3 has several biochemical functions, for example, ATPase activator activity, actin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYBPC3 itself. We selected most functions MYBPC3 had, and list some proteins which have the same functions with MYBPC3. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase activator activity
Related Protein RAB4A; ATP1B3; MYBPC3; TOR1AIP2; ATP1B1; TOR1AIP1; DNAJC10; AHSA1; DNAJC15; AHSA2
Function actin binding
Related Protein HIP1R; ADD1; KLHL1; IPP; SNTA1; MYBPC2; MYRIP; ABRAB; CNN3B; MYH11A
Function identical protein binding
Related Protein GRIN3A; CEP72; CHAF1A; WAS; DAPK1; DYNLT1C; CBY1; ST13; MNS1; ZBTB16
Function metal ion binding
Related Protein ZNF781; MT4; AOX3L1; FAM96A; ADAM25; KDM2BA; MUSK; RAF1B; CPPED1; TOPAZ1
Function myosin binding
Related Protein GIPC1; ARFGEF2; SLC6A4; ACTA1; FXYD1; CALM; VETZ; MYBPC3; ARFGEF1; VEZT
Function myosin heavy chain binding
Related Protein MYL12B; CORO1A; PDLIM2; MYL2; MYBPC3; AMPD1; MYL9
Function protein binding
Related Protein PSMB4; RNF2; CSNK2B; AGBL1; NR2C1; GSPT2; RPS6KA1; SSX3; LGALSL; MCM6
Function structural constituent of muscle
Related Protein JPH1; MYL3; CSRP3; PDLIM3; MYL6; MYOM1; MYL9; MYL5; MYL2; MYLPF
Function titin binding
Related Protein CALM3; CALM1; CALM2; ANKRD1; CALM; CAMK2D; MYBPC1; CAPN3; TRIM63; OBSCN

Interacting Protein

MYBPC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYBPC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYBPC3.
PDE4DIP; SVIL; MYZAP; CNN1; ACTB; ACTC1; FLNC; TNNI3K; SPATA20; PARD3; TRIM63; CCT7; SMURF2