myh9
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  • Official Full Name
  • myosin, heavy chain 9, non-muscle
  • Background
  • This gene encodes a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain. The protein is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in MYH9 are the cause of non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness.
  • Synonyms
  • MYH9; myosin, heavy chain 9, non-muscle; DFNA17, myosin, heavy polypeptide 9, non muscle; myosin-9; EPSTS; FTNS; MHA; NMHC II A; NMMHCA; nonmuscle myosin heavy chain II A; myosin heavy chain 9; non-muscle myosin heavy chain A; non-muscle myosin heavy cha
Cat.#:MYH9-29659THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYH9, His-tagged
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Cat.#:MYH9-29HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MYH9, GST-tagged
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Cat.#:MYH9-30HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYH9, GST-tagged
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Cat.#:MYH9-31HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MYH9, GST-tagged
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Cat.#:MYH9-10309MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MYH9 Protein
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Cat.#:MYH9-3850RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MYH9 Protein
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Cat.#:MYH9-7026CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MYH9
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Involved Pathway

MYH9 involved in several pathways and played different roles in them. We selected most pathways MYH9 participated on our site, such as Tight junction, Regulation of actin cytoskeleton, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYH9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Tight junction
MYH7; HCLS1; CLDN15LB; PTEN; EPB41L3; AKT2L; MYH1E; PARD6B; CLDN22; RRAS2
Regulation of actin cytoskeleton
PTK2; PIP5K1AA; FGF1B; FGF11A; DIAPH1; MYL9B; APC; ITGA11A; PDGFB; ARHGEF12
Salmonella infection
CCL4L1; CDC42L; IFNGR2; TLR5; NOS2B; IFNG1-2; DYNC1I2A; WASB; CASP1; TLR4BA

Protein Function

MYH9 has several biochemical functions, for example, ADP binding, ATP binding, ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYH9 itself. We selected most functions MYH9 had, and list some proteins which have the same functions with MYH9. You can find most of the proteins on our site.
Function
Related Protein
Function ADP binding
Related Protein GCLC; ME1; PKM; APAF1; LONP1; ERN1; HSP104; PRPS2; GLUD2; MYO9B
Function ATP binding
Related Protein DDX58; SMC2; ADCY9; RPS6KAL; ADRBK2; PLK5; PIP5KL1; ADCK2; RAD50; MYLK2
Function ATPase activity
Related Protein WRN; MLH1; ABCB6A; ABCA1B; ABCC5; SMARCA4A; PEX6; NSFB; NSF; MLH3
Function actin binding
Related Protein MAEA; MYO19; SMTNL; PIP; DIAPH1; SYNE1; EPB41L3B; MED28; FKBP15; CAPZA1A
Function actin filament binding
Related Protein EGFR; CTNNA3; GAS2L2; FMNL1; ADD1; MYH9; WIPF2B; TLN1; PICK1; MYO7A
Function contributes_to actin filament binding
Related Protein MYH10; ARPC4; ARPC5; MYH9; ACTR3; ARPC3; ARPC2; ARPC1B; ACTR2
Function actin-dependent ATPase activity
Related Protein MYO1D; MYH7; MYH9; MYO3A; MYO1C; MYO7A; MYL6; MYH10
Function contributes_to actin-dependent ATPase activity
Related Protein MYH10; MYH9
Function calmodulin binding
Related Protein CAMK2B; CAMK1GB; SLC9A1; RASGRF2; MYO1D; KCNN1A; IQCB1; AKAP5; MARCKS; ORAI1
Function microfilament motor activity
Related Protein MYH10; MYO5B; MYO3B; MYO1E; MYH8; MYO7A; MYH9; MYO3A; MYO9B; STRC
Function motor activity
Related Protein MYO1C; MYO15; MYHZ1.1; MYO1A; CGNB; MYO6; MYH4; MYH9A; DYNC2H1; MYH7B
Function poly(A) RNA binding
Related Protein KIAA0020; EIF3C; TES; LARP1; RPS18; NKRF; PCSK9; CROP; CHST13; ARHGEF1
Function protein anchor
Related Protein SLC4A1; NUP153; PDCD6; AKAP6; ALG14; MYH9; SUN3; CIB1; SUN5; SUN1
Function protein binding
Related Protein TBC1D2; NDUFAF4; WDHD1; HOXB7; LIN28B; FHL5; ZNF433; MYH9; AACS; FCRL4
Function protein domain specific binding
Related Protein NEFL; COX4I2; GUSB; MPP7; SERPINB1A; RAB6A; DYNLL1; YWHAG1; GABRR1; HOXB1
Function protein homodimerization activity
Related Protein BCL2; NTRK1; CHMP4A; ANXA6; GDF7; CCDC88A; GSTZ1; BAK1; DGCR8; CHRNA7

Interacting Protein

MYH9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYH9 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYH9.
GRB2; MEN1; SVIL; ESR1; CXCR4

MYH9 Related Articles

Paul, A; Babji, S; et al. Human and bovine rotavirus strain antigens for evaluation of immunogenicity in a randomized, double-blind, placebo-controlled trial of a single dose live attenuated tetravalent, bovine-human-reassortant, oral rotavirus vaccine in Indian adults. VACCINE 32:3094-3100(2014).
Nagatake, T; Fujita, H; et al. Enteroendocrine Cells Are Specifically Marked by Cell Surface Expression of Claudin-4 in Mouse Small Intestine. PLOS ONE 9:-(2014).