myl2
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  • Official Full Name
  • Myosin regulatory light chain 2
  • Background
  • Myosins comprise a family of ATP-dependent motor proteins and are best known for their role in muscle contraction and their involvement in a wide range of other eukaryotic motility processes. They are responsible for actin-based motility. The term was originally used to describe a group of similar ATPases found in striated and smooth muscle cells. Following the discovery by Pollard and Korn of enzymes with myosin-like function in Acanthamoeba castellanii, a large number of divergent myosin genes have been discovered throughout eukaryotes. Thus, although myosin was originally thought to be restricted to muscle cells (hence, "myo"), there is no single "myosin" but rather a huge superfamily of genes whose protein products share the basic properties of actin binding, ATP hydrolysis (ATPase enzyme activity), and force transduction. Virtually all eukaryotic cells contain myosin isoforms. Some isoforms have specialized functions in certain cell types (such as muscle), while other isoforms are ubiquitous. The structure and function of myosin is strongly conserved across species, to the extent that rabbit muscle myosin II will bind to actin from an amoeba.
  • Synonyms
  • Myosin regulatory light chain 2; MYL2
Cat.#:MYL2-5808HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYL2 Protein, GST-tagged
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Cat.#:MYL2-27837THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYL2, His-tagged
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Cat.#:MYL2-28864THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYL2, His-tagged
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Cat.#:MYL2-10314MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MYL2 Protein
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Cat.#:MYL2-3854RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MYL2 Protein
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Cat.#:MYL2-4680CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MYL2
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Cat.#:MYL2-388HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Slow Cardiac Myosin Regulatory light chain 2, His-tagged
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Cat.#:MYL2-235HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Myosin, Light Chain 2, Regulatory, Cardiac, Slow
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Cat.#:MYL2-4028HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MYL2 293 Cell Lysate
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Involved Pathway

MYL2 involved in several pathways and played different roles in them. We selected most pathways MYL2 participated on our site, such as Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cardiac muscle contraction
VMHC; COX7A2L; CACNB2; COX5B2; ATP1A1; COX5A; MYH7; ATP1B3A; TPM4A; CACNA2D1A
Adrenergic signaling in cardiomyocytes
PPP2R5A; ATP2B1; ATF4B1; VMHCL; GNAI2; PRKACBB; ATP1A2A; CACNB2A; ADRa1A; CACNA1D
Focal adhesion
ITGA6; LAMA4; FLNB; ACTN3; PIK3R3B; ROCK2; AASS; KDR; AKT2L; ITGB3B
Tight junction
CSNK2A2A; PRKCZ; RRAS; MYL12.1; VAPA; JAM3B; ACTN4; CLDN15; CLDNF; MYLPFB
Leukocyte transendothelial migration
CYBA; CLDN17; NCF4; VASP; MSN; PIK3CG; ITGB2; PIK3R2; AASS; GNAI3
Regulation of actin cytoskeleton
MAP2K2A; PXN; MYL2; BDKRB1; CHRM5B; ITGB3; PPP1R12C; PFN2L; ACTB1; PXNA
Hypertrophic cardiomyopathy (HCM)
ITGA2; CACNB2; CACNB4; PRKAB1; ACTC1; ITGB4; IL6; ITGB6; TGFB3; ITGA4
Dilated cardiomyopathy
EMD; CACNG7; PRKACB; SGCG; ITGA2; ITGB1; MYBPC3; CACNA2D3; TGFB2; CACNG1

Protein Function

MYL2 has several biochemical functions, for example, actin monomer binding, calcium ion binding, myosin heavy chain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYL2 itself. We selected most functions MYL2 had, and list some proteins which have the same functions with MYL2. You can find most of the proteins on our site.
Function
Related Protein
Function actin monomer binding
Related Protein LIMA1; TMSB4X; COBLL1; KLHL8; MKL1; TMSB; MYL2; TMSB10; PRKCE; PFN4
Function calcium ion binding
Related Protein DSG2.1; DLB; CASQ1B; PCDHB5; CABP1B; KCNIP2; SYT9B; CABP4; SYT5A; PADI6
Function myosin heavy chain binding
Related Protein MYL12B; PDLIM2; MYL9; MYBPC3; CORO1A; AMPD1; MYL2
Function protein binding
Related Protein HPCAL1; SYTL2; TNK1; CPSF4; EVLA; NAP1L1; FKBPL; RRAS2; ID3; RFX4
Function structural constituent of muscle
Related Protein MYLPF; DMD; MYBPC3; MYBPC1; TPM1; PLEC; MYBPH; MYL5; TPM4; MYL6

Interacting Protein

MYL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYL2.
USP6; GJB5; LRSAM1; NHP2

MYL2 Related Articles

Colson, BA; Petersen, KJ; et al. The myosin super-relaxed state is disrupted by estradiol deficiency. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 456:151-155(2015).
Wang, L; Muthu, P; et al. Diversity and similarity of motor function and cross-bridge kinetics in papillary muscles of transgenic mice carrying myosin regulatory light chain mutations D166V and R58Q. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 62:153-163(2013).