Recombinant Human NDRG1 Protein, His-tagged

• Cat.No.: NDRG1-008H
• Product Overview: Recombinant Human NDRG1 Protein with His tag was expressed in E. coli.

Specification

• Description: N-myc downstream-regulated gene 1 (NDRG1), also termed Cap43, Drg1, RTP/rit42, and Proxy-1, is a member of the NDRG family, which is composed of four members (NDRG1-4) that function in growth, differentiation, and cell survival. NDRG1 is ubiquitously expressed and highly responsive to a variety of stress signals, including DNA damage, hypoxia, and elevated levels of nickel and calcium. Expression of NDRG1 is elevated in N-myc defective mice and is negatively regulated by N- and c-myc. During DNA damage, NDRG1 is induced in a p53-dependent fashion and is necessary for p53-mediated apoptosis. Research studies have shown that NDRG1 may also play a role in cancer progression by promoting differentiation, inhibiting growth, and modulating metastasis and angiogenesis. Nonsense mutation of the NDRG1 gene has been shown to cause hereditary motor and sensory neuropathy-Lom (HMSNL), which is supported by studies demonstrating the role of NDRG1 in maintaining myelin sheaths and axonal survival. NDRG1 is upregulated during mast cell maturation and its deletion leads to attenuated allergic responses. Both NDRG1 and NDRG2 are substrates of SGK1, although the precise physiological role of SGK1-mediated phosphorylation is not known. NDRG1 is phosphorylated by SGK1 at Thr328, Ser330, Thr346, Thr356, and Thr366. Phosphorylation by SGK1 primes NDRG1 for phosphorylation by GSK-3.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: ~43 kDa
• AA Sequence: HMSREMQDVDLAEVKPLVEKGETIT GLLQEFDVQEQDIETLHGSVHVTLC GTPKGNRPVILTYHDIGMNHKTCYN PLFNYEDMQEITQHFAVCHVDAPGQ QDGAASFPAGYMYPSMDQLAEMLPG VLQQFGLKSIIGMGTGAGAYILTRF ALNNPEMVEGLVLINVNPCAEGWMD WAASKISGWTQALPDMVVSHLFGKE EMQSNVEVVHTYRQHIVNDMNPGNL HLFINAYNSRRDLEIERPMPGTHTV TLQCPALLVVGDSSPAVDAVVECNS KLDPTKTTLLKMADCGGLPQISQPA KLAEAFKYFVQGMGYMPSASMTRLM RSRTASGSSVTSLDGTRSRSHTSEG TRSRSHTSEGTRSRSHTSEGAHLDI TPNSGAAGNSAGPKSMEVSCLE
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Storage Buffer: PBS, pH7.4

Gene Information

• Gene Name: NDRG1 N-myc downstream regulated 1 [ Homo sapiens (human) ]
• Official Symbol: NDRG1
• Synonyms: NDRG1; N-myc downstream regulated 1; CAP43; protein NDRG1; DRG1; NDR1; RTP; TDD5; DRG-1; protein regulated by oxygen-1; tunicamycin-responsive protein; differentiation-related gene 1 protein; nickel-specific induction protein Cap43; N-myc downstream-regulated gene 1 protein; reducing agents and tunicamycin-responsive protein; GC4; NMSL; CMT4D; HMSNL; RIT42; TARG1; PROXY1
• Gene ID: 10397
• mRNA Refseq: NM_001135242
• Protein Refseq: NP_001128714
• MIM: 605262
• UniProt ID: Q92597

Reviews

11/22/2020

Their expertise and assistance have been invaluable in troubleshooting and providing insightful solutions, greatly enhancing the progress of my experiments.

08/26/2020

They have proven to be a timely and reliable resource, readily addressing any concerns or challenges that arise during my research.

06/05/2018

The NDRG1 Protein's superior stability and functional performance render it an indispensable tool for a wide range of scientific investigations.

Q&As

Can NDRG1 be targeted for personalized medicine approaches?

Yes, understanding the individual's NDRG1 expression profile may enable personalized treatment strategies, especially in cancer therapy.

Are there therapeutic implications for modulating NDRG1 expression in cancer treatment?

Are there therapeutic implications for modulating NDRG1 expression in cancer treatment?

Are there clinical trials investigating the use of NDRG1-related therapies?

Yes, there are ongoing clinical trials exploring the safety and efficacy of NDRG1-targeted therapies in various diseases, reflecting the growing interest in its clinical applications.

How does NDRG1 contribute to cellular stress response?

NDRG1 is involved in cellular responses to various stresses, including oxidative stress and DNA damage, playing a role in maintaining cellular homeostasis.

How does NDRG1 affect cardiovascular health?

NDRG1 is involved in processes related to cardiac hypertrophy and response to ischemic stress, making it relevant to cardiovascular diseases.