Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

NPPA

Official Full Name

natriuretic peptide A
Overview

Atrial natriuretic peptide (ANP), atrial natriuretic factor (ANF), atrial natriuretic hormone (ANH), or atriopeptin, is a powerful vasodilator, and a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and fat (adipose tissue). It is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes), in response to high blood pressure. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure.
Synonyms

Nppa; natriuretic peptide precursor A; ANF; ANP; Pnd; RATANF; natriuretic peptides A; prepronatriodilatin; atrial natriuretic factor; atrial natriuretic peptide; natriuretic peptide precursor type A; Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd); Auriculin-B; Auriculin-A; Atriopeptin-1; Atriopeptin I; Atriopeptin-2; Atriopeptin II; Atriopeptin-3; Atriopeptin IIIy;

Type

Recombinant Proteins
Cell & Tissue Lysates
Transfected Stable Cell Lines
Protein Pre-coupled Magnetic Beads

Species

Cattle
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ
Yeast

Tag

GST
His
His (Fc)
Avi
His|GST
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NPPA-27326TH	Recombinant Human NPPA	Wheat Germ	N/A	153 amino acids	Inquiry
Human	NPPA-35H	Recombinant Human NPPA protein, His-tagged	E.coli	His		Inquiry
Human	NPPA-2689H	Recombinant Human NPPA protein, His & GST-tagged	E.coli	His/GST	Ala25~Arg123	Inquiry
Human	NPPA-1347H	Recombinant Human NPPA, GST-tagged	E.coli	GST	1-153aa	$319 / 25ug
Human	NPPA-3735HCL	Recombinant Human NPPA 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NPPA-1252H	Recombinant Human NPPA protein, His-tagged	Yeast	His	78-115AA	Inquiry
Human	NPPA-6041H	Recombinant Human NPPA Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	NPPA-347HF	Recombinant Full Length Human NPPA Protein	In Vitro Cell Free System		153 amino acids	Inquiry
Human	NPPA-6641HF	Recombinant Full Length Human NPPA Protein, GST-tagged	In Vitro Cell Free System	GST	153 amino acids	Inquiry
Human	NPPA-4730H	Recombinant Human NPPA Protein (Ala25-Arg123), N-GST tagged	E.coli	N-GST	Ala25-Arg123	Inquiry
Human	NPPA-3689H	Recombinant Human NPPA protein, His-tagged	E.coli	His	26-153 aa	$319 / 25ug
Human	NPPA-385H	Recombinant Human NPPA Protein, His-tagged	E.coli	N-His	Ser124-Tyr151	Inquiry
Human	NPPA-79H	Human Atrial Natriuretic Factor Reference standard		N/A		Inquiry
Human	NPPA-1850H	Recombinant Human NPPA Protein, His&GST-tagged	E.coli	N-His&GST	Lys41-Tyr151	Inquiry
Mouse	NPPA-10830M	Recombinant Mouse NPPA Protein	Mammalian Cell	His		Inquiry
Mouse	Nppa-2690M	Recombinant Mouse Nppa protein, His & T7-tagged	E.coli	His/T7	Asn25~Arg122 (Accession # P05125)	Inquiry
Mouse	Nppa-260M	Recombinant Mouse Nppa Protein, His/GST-tagged	E.coli	His/GST	Asn25~Arg152	Inquiry
Mouse	NPPA-6169M-B	Recombinant Mouse NPPA Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	NPPA-6169M	Recombinant Mouse NPPA Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	Nppa-263R	Recombinant Rat Nppa Protein, His-tagged	E.coli	His	Asn25~Arg122	Inquiry
Rat	Nppa-261R	Recombinant Rat Nppa Protein, His/GST-tagged	E.coli	His/GST	Asn25~Arg152	Inquiry
Rat	Nppa-386R	Recombinant Rat Nppa Protein, His&GST-tagged	E.coli	N-His&GST	Asn25-Arg122	Inquiry
Rat	Nppa-387R	Recombinant Rat Nppa Protein, His-tagged	E.coli	N-His	Asn25-Arg122	Inquiry
Cattle	NPPA-259C	Recombinant Cattle NPPA Protein, His-tagged	E.coli	His	Asn25~Arg152	Inquiry
Zebrafish	NPPA-9835Z	Recombinant Zebrafish NPPA	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NPPA Related Articles
NPPA Related Research Area

NPPA involved in several pathways and played different roles in them. We selected most pathways NPPA participated on our site, such as HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
HIF- signaling pathway	MTOR;STAT3;TCEB2;PFKL;NFKB1;TEK;TCEB1;ANGPT4;NPPA

NPPA has several biochemical functions, for example, neuropeptide hormone activity, neuropeptide receptor binding, peptide hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPPA itself. We selected most functions NPPA had, and list some proteins which have the same functions with NPPA. You can find most of the proteins on our site.

Function	Related Protein
neuropeptide hormone activity	AGRP;GAL;CCK;NPFFL;PENK;NPPA;POMCA;PPY;NPFF
neuropeptide receptor binding
peptide hormone receptor binding	FYN;PTH;NPPC;PTPN11;PTHLHA;ADCYAP1;RUNDC3A;JAK2;PTHLH
protein binding	KCNIP2;CDC34;RBBP4;PMS2;PLIN1;PKM;C22orf13;C2orf65;FAM131B
receptor binding	PTK2AB;SERPINE2;LGI1;RASA1;CCL15;NXPH1;TIGIT;CHRNA10;CXADR

NPPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPPA here. Most of them are supplied by our site. Hope this information will be useful for your research of NPPA.

MAGEA12; UBQLN1; UBQLN4

Pereira, NL; Tosakulwong, N; et al. Circulating Atrial Natriuretic Peptide Genetic Association Study Identifies a Novel Gene Cluster Associated With Stroke in Whites. CIRCULATION-CARDIOVASCULAR GENETICS 8:141-U292(2015).

Ovchinnikov, DA; Hidalgo, A; et al. Isolation of Contractile Cardiomyocytes from Human Pluripotent Stem-Cell-Derived Cardiomyogenic Cultures Using a Human NCX1-EGFP Reporter. STEM CELLS AND DEVELOPMENT 24:11-20(2015).

Cardiac Stem Cell Markers