ntrk2
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  • Official Full Name
  • neurotrophic tyrosine kinase, receptor, type 2
  • Background
  • This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • NTRK2; neurotrophic tyrosine kinase, receptor, type 2; TRKB; trk-B; GP145-TrkB; BDNF/NT-3 growth factors receptor; trkB tyrosine kinase; tyrosine kinase receptor B; tropomyosin-related kinase B; BDNF-tropomyosine receptor kinase B; neurotrophic tyrosine receptor kinase type 2
Cat.#:NTRK2-379HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NTRK2 Protein, His-tagged
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Cat.#:NTRK2-109HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTRK2, Fc Chimera
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Cat.#:NTRK2-157HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTRK2, His tagged
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Cat.#:NTRK2-158HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTRK2, Fc-His tagged
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Cat.#:NTRK2-159HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTRK2 Protein, Fc-tagged
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Cat.#:NTRK2-31620THTag:
Source (Host):Species:Human
Product nameRecombinant Human NTRK2
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Cat.#:NTRK2-31621THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human NTRK2, Fc-tagged
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Cat.#:NTRK2-449HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NTRK2, GST-tagged, Active
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Cat.#:NTRK2-496HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Neurotrophic Tyrosine Kinase, Receptor, Type 2
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Cat.#:NTRK2-718HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NTRK2, GST-His
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Cat.#:NTRK2-751HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human NTRK2 Protein, DDK/His-tagged
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Cat.#:NTRK2-752HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human NTRK2 Protein, DDK-tagged
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Cat.#:NTRK2-87HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human NTRK2 protein, Flag-tagged, Biotinylated
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Cat.#:Ntrk2-1353MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ntrk2, His tagged
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Cat.#:Ntrk2-359MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse Ntrk2 Protein, His-tagged
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Cat.#:NTRK2-1095RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat NTRK2 Protein, His-tagged
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Cat.#:NTRK2-4103RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NTRK2 Protein
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Cat.#:Ntrk2-7471RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Ntrk2, Fc tagged
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Cat.#:NTRK2-3118RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NTRK2 Protein, His-tagged
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Cat.#:NTRK2-1041CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine NTRK2 Protein, Fc-tagged
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Cat.#:NTRK2-6784CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NTRK2
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Cat.#:NTRK2-2683HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTRK2 cell lysate
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Cat.#:NTRK2-1843MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse NTRK2 cell lysate
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Cat.#:NTRK2-1300RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat NTRK2 cell lysate
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Cat.#:NTRK2-1024CCLTag:
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine NTRK2 cell lysate
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Cat.#:Kit-1547Tag:
Source (Host):Species:
Product nameU2OS TrkB Bioassay Kit
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Cat.#:Kit-1629Tag:
Source (Host):Species:
Product nameTrkB Functional Assay Kit
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Involved Pathway

NTRK2 involved in several pathways and played different roles in them. We selected most pathways NTRK2 participated on our site, such as MAPK signaling pathway, Neurotrophin signaling pathway, Alcoholism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NTRK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF13; TRAF6; MAPK14A; NTRK2B; MAPK12A; RAC3A; HSP70; MAP3K1; MAPK8B; RASGRF2
Neurotrophin signaling pathway
NTF4; NTRK1; ATF4; MAGED1; MAPK10; IKBKB; RIPK2; NGFR; TP53; RPS6KA1
Alcoholism
HIST1H2BF; HIST1H3C; SHC3; HIST1H2AP; HIST1H2BC; HIST1H2AF; CAMK4; ATF6B; DRD1; H3F3B

Protein Function

NTRK2 has several biochemical functions, for example, ATP binding, brain-derived neurotrophic factor binding, brain-derived neurotrophic factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NTRK2 itself. We selected most functions NTRK2 had, and list some proteins which have the same functions with NTRK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PAPSS2A; ACSL3; SMC1A; PAK2; IRAK2; TOR1L3; TRP53; SETX; FLT4; ATPBD4
Function brain-derived neurotrophic factor binding
Related Protein NTRK2
Function brain-derived neurotrophic factor-activated receptor activity
Related Protein NTRK2
Function neurotrophin binding
Related Protein NTRK1; NTRK2; NGFR; NTRK3
Function protein homodimerization activity
Related Protein TENM1; IL6ST; PDE2A; NR6A1; PTS; DMRT2B; NAGA; UGT1A9; APOE; NOD1

Interacting Protein

NTRK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NTRK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NTRK2.
saicar; PKM; SORT1; abl-tide; HSP90AB1; NTF4; EGFR; POLR2G; AP1B1; NMNAT1

NTRK2 Related Articles

Pajtler, KW; Mahlow, E; et al. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. ONCOTARGET 5:11180-11192(2014).
Wessels, JM; Wu, L; et al. The Brain-Uterus Connection: Brain Derived Neurotrophic Factor (BDNF) and Its Receptor (Ntrk2) Are Conserved in the Mammalian Uterus. PLOS ONE 9:-(2014).