pak1
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  • Official Full Name
  • p21 protein (Cdc42/Rac)-activated kinase 1
  • Background
  • Alpha PAK p68, beta PAK p65 and gamma PAK p62 are three isoforms of serine/threonine kinases. These three isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation.
  • Synonyms
  • PAK1; p21 protein (Cdc42/Rac)-activated kinase 1; p21/Cdc42/Rac1 activated kinase 1 (STE20 homolog, yeast) , p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related); serine/threonine-protein kinase PAK 1; STE20 homolog; yeast; p65-PAK; alpha-PAK; STE20 homolog, yeast; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); PAKalpha; MGC130000; MGC130001
Cat.#:PAK1-5512HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Protein (Cdc42/Rac)-Activated Kinase 1, GST-tagged
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Cat.#:PAK1-768HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAK1 Protein, His-tagged
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Cat.#:PAK1-1259HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAK1, GST-tagged
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Cat.#:PAK1-1513HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAK1, GST-tagged
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Cat.#:PAK1-17HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAK1
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Cat.#:PAK1-821HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAK1 Protein, GST-tagged
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Cat.#:PAK1-4259RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PAK1 Protein
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Cat.#:PAK1-3962CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PAK1
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Cat.#:PAK1-11475ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PAK1
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Cat.#:PAK1-378HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PAK1, GST-tagged, Active
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Cat.#:PAK1-1070Tag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human P21 Protein (Cdc42/Rac)-Activated Kinase 1, GST-tagged
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Cat.#:PAK1-1275HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAK1 cell lysate
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Involved Pathway

PAK1 involved in several pathways and played different roles in them. We selected most pathways PAK1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGFR4; NTRK1; CACNA2D2; FGF4; RAC3A; BDNF; PDGFRB; PRKCBA; FGF22; FGF13
ErbB signaling pathway
MTOR; ERBB4A; CBLC; STAT5B; HRAS; NRG2; ERBB2; SOS1; STAT5A; AREG
Ras signaling pathway
FGFR4; RHOA; PLA2G2D; MLLT4; Kitl; PDGFD; CSF1; SHC3; KITLG; PLA2G5
cAMP signaling pathway
CAMK2B; GRIA1; BRAF; PLN; GNAI1; F2R; PIK3CA; RAP1B; HTR1E; CREB3L2
Chemokine signaling pathway
GNG2; CXCL10; CCL26; CCL14; ADRBK2; CCR10; CCL25; GNG8; PRKACA; CCR5
Axon guidance
GDNF; KDR; PPP3R2; CSF2RB; GNAI3; ARPC5; SEMA3B; SCN2A; EPHB2; CSK
Focal adhesion
TNXB; CAV1; MAPK9; PDGFB; PAK1; PDGFAB; MAPK8A; THBS4B; RAPGEF1; PDGFAA
Natural killer cell mediated cytotoxicity
ULBP2; FCGR3A; BRAF; LCK; PIK3CB; PLCG2; IFNA2; IFNA16; NFATC1; IFNA13
T cell receptor signaling pathway
VAV3; CDC42; SHB; CD28; PIK3R5; CBLC; NFKBIB; CD4; PAK1; MAP2K1
Fc gamma R-mediated phagocytosis
LAT; PIK3R2; SCIN; FCGR1A; VAV2; PRKCG; WASF2; RAC2; PIK3CD; PTPRC
Regulation of actin cytoskeleton
INSB; FGF11; ROCK2A; FGFR3; ARPC5B; PDGFD; IQGAP3; RHOAA; PIP5K2; PDGFAA
Epithelial cell signaling in Helicobacter pylori infection
PLCG2; IKBKB; CXCR1; ATP6V1B2; ATP6V1G3; JAM2; ATP6V1C1; MAPK12; MAP3K14; ATP6V1D
Proteoglycans in cancer
PIK3CA; SOS1; PPP1R12B; FAS; RPS6KB1; WNT8A; CAMK2B; RRAS2; PRKCB; CAMK2G
Renal cell carcinoma
PIK3CG; FLCN; HGF; RAF1; PIK3R1; CUL2; TGFB3; FH1; RAP1B; PIK3R2

Protein Function

PAK1 has several biochemical functions, for example, ATP binding, Rac GTPase binding, collagen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK1 itself. We selected most functions PAK1 had, and list some proteins which have the same functions with PAK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PRKD3; ABCB3L1; TRNT1; AKT3; BMPR1BA; PEO1; MAPK14B; ATP12A; ATAD3A; PCXA
Function Rac GTPase binding
Related Protein CAV1; HACE1; RAB7; NOX1; PAK2; SRGAP3; SOD1; NCF2; FLNA; PAK6
Function collagen binding
Related Protein LRRC15; SERPINH1B; NID1; ITGA3; PDGFA; SERPINH2; CD44; NID2; DCN; CTSK
Function protein binding
Related Protein LRRC6; KRT81; HSPB11; COG2; HDAC7A; RND1; TLE1; UBD; BEGAIN; TRIM25
Function contributes_to protein binding
Related Protein TGFBR3; ACVR2A; PAK1; INHA; TAF10; MSH2; POLR2A; INTS10; CRY1A; MLH1
Function protein kinase activity
Related Protein MAP2K4B; NLK2; PRKACAA; PRKACBB; HIPK3; TEX14; STK38A; VRK1; PRKD2; AKT2L
Function protein serine/threonine kinase activity
Related Protein GSK3B; TAOK3; ACVR2AA; TRPM6; EIF2AK3; TTK; MAP2K1; NLK2; PLK2; ULK1A

Interacting Protein

PAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK1.
RAC1

PAK1 Related Articles

Butz, M; Kast, P; et al. Affinity maturation of a computationally designed binding protein affords a functional but disordered polypeptide. JOURNAL OF STRUCTURAL BIOLOGY 185:168-177(2014).
Gallicchio, MA; Bach, LA; et al. Uptake of advanced glycation end products by proximal tubule epithelial cells via macropinocytosis. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1833:2922-2932(2013).