Recombinant Human PAK1 Protein (Glu252-Cys501), His tagged

• Cat.No.: PAK1-2727H
• Product Overview: Recombinant human PAK1 (Glu252-Cys501) protein fused with His tag was expressed in E. coli.

Specification

• Description: P21-activated kinase-1 (PAK1) is an enzyme associated with multiple metabolic networks and different types of cancers.PAK1 (RAC/CDC42-activated kinase 1) is the major oncogenic/ageing kinase, and its dysfunction extends the healthy lifespan of C. elegans by activating HSP16 gene.The p21 protein (Cdc42/Rac) -activated kinase 1 (PAK1) expression appears to be predictive of prognosis in various solid tumors.PAK1 expression may be a predictive marker of overall survival and disease-specific survival in patients with solid tumors.p21-Activated kinase 1 (PAK1) has attracted much attention as a potential therapeutic target due to its central role in many oncogenic signaling pathways, its frequent dysregulation in cancers and neurological disorders, and its tractability as a target for small-molecule inhibition.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 27.85 kDa
• Protein Length: Glu252-Cys501
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: PAK1 p21 protein (Cdc42/Rac) -activated kinase 1 [ Homo sapiens (human) ]
• Official Symbol: PAK1
• Synonyms: PAK1; p21 protein (Cdc42/Rac) -activated kinase 1; p21/Cdc42/Rac1 activated kinase 1 (STE20 homolog, yeast), p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related); serine/threonine-protein kinase PAK 1; STE20 homolog; yeast; p65-PAK; alpha-PAK; STE20 homolog, yeast; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); PAKalpha; MGC130000; MGC130001
• Gene ID: 5058
• mRNA Refseq: NM_001128620
• Protein Refseq: NP_001122092
• MIM: 602590
• UniProt ID: Q13153