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Official Full Name p21 protein (Cdc42/Rac)-activated kinase 2
Background Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene. The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
Synonyms p21 protein (Cdc42/Rac)-activated kinase 2; PAK65; PAKgamma; PAK2; p21-activated kinase 2; S6/H4 kinase; p21 (CDKN1A)-activated kinase 2; EC; PAK-2; Gamma-PAK; p58
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PAK2-1276HCL Recombinant Human PAK2 cell lysate N/A
    Human PAK2-1282H Recombinant Human p21 Protein (Cdc42/Rac)-Activated Kinase 2, GST-tagged Insect Cell GST
    Human PAK2-30670TH Recombinant Human PAK2 E.coli N/A
    Human PAK2-521H Recombinant Human P21 Protein (Cdc42/Rac)-Activated Kinase 2 E.coli N/A
    Human PAK2-721H Recombinant Human PAK2, GST-His Sf9 Insect Cell GST
    Human PAK2-767H Recombinant Human PAK2 Protein, His-tagged E.coli His
    Mouse PAK2-12319M Recombinant Mouse PAK2 Protein Mammalian Cell His
    Rat PAK2-4260R Recombinant Rat PAK2 Protein Mammalian Cell His
    Rhesus Macaque PAK2-3291R Recombinant Rhesus monkey PAK2 Protein, His-tagged Mammalian Cell His

    PAK2 involved in several pathways and played different roles in them. We selected most pathways PAK2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway JIP1; KRAS; FASLG; CACNA2D1; MAP3K7; CACNG6A; HRASA; MAPK8IP2; CACNA2D2; MAP4K1
    ErbB signaling pathway MAP2K7; BAD; PTK2AB; NCK2A; ARAF; RPS6KB1B; PRKCB; GRB2A; ABL1; GRB2B
    Ras signaling pathway FGF9; IKBKB; FIGF; MAPK8; ABL1; SHC1; PGF; ANGPT1; PAK3; RAB5B
    Axon guidance NTN1; GNAI3; TRPC7; SEMA4B; NFATC3; ABLIM2; RAC1; SEMA5B; SLIT3; PAK4
    Focal adhesion ITGB1; FYNB; LAMB4; PTK2; COL6A1; VTN; VWF; RHOAC; SRC; TESK2
    T cell receptor signaling pathway MUC1; SOS1; MAPK3; GRAPA; RHOA; DLG1; NFKBIE; MAPK1; EVLB; OXSR1A
    Regulation of actin cytoskeleton SOS1; PIP5K1BB; CD14; BAIAP2A; ITGAV; RAC3B; SLC9A1; FGF6B; RRAS2; SSH2
    Renal cell carcinoma RAPGEF1; HRAS; PIK3R2; MAP2K2; HIF1A; ARNT; EP300; EGLN1; TCEB1; KRAS

    PAK2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK2 itself. We selected most functions PAK2 had, and list some proteins which have the same functions with PAK2. You can find most of the proteins on our site.

    Function Related Protein
    Rac GTPase binding PAK2A; OCRL; ARHGEF2; PAK3; SOD1; SRGAP3; PAK1; SRGAP1; DVL1; FMNL1
    identical protein binding SIAH1; LYZ1; STK10; AMOTL2; MTSS1; IL12B; TYROBP; MAP3K11; CLDN14; PICK1
    protein binding MED22; PDE3B; TMEM100; RAB22A; SIM1; PPP1R12A; COLQ; SEPT7; PICALM; ATG5
    protein kinase activity SOX9; PTK2; CDK5; ABL1; PDK4; NRBP1; KDRL; GUCY2E; TGFBR1; CAMK2B1
    protein kinase binding ADCY6; TELO2; CD3E; AKAP7; STAP1; H2AFY; TRPV4; NSF; TP53; SHC4
    protein serine/threonine kinase activity PRKCBA; PRKACAA; LATS1; MELK; CAMKK1A; DYRK1B; GRK5; IRAK2; CSNK1DB; CSNK1D
    protein tyrosine kinase activator activity NRG1; GAS6; ABI1; ERBB3; CD24; Cd24a; ABI1A; ABI1B; PAK2; GHRL

    PAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK2.


    Lacombe, J; Mange, A; et al. A Multiparametric Serum Marker Panel as a Complementary Test to Mammography for the Diagnosis of Node-Negative Early-Stage Breast Cancer and DCIS in Young Women. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 23:1834-1842(2014).
    Lulf, S; Matz, J; et al. Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody. RETROVIROLOGY 11:-(2014).

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