Recombinant Active Human PAK2 (Y443N) Mutant Protein, GST-tagged

• Cat.No.: PAK2-35H
• Product Overview: Recombinant full-length human PAK2 (Y443N) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
• Source: Insect cell
• Species: Human
• Tag: GST
• Molecular Mass: Approx 95 kDa
• Purity: > 90%
• Stability: One year at -70 centigrade from data of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μL
• Storage Buffer: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 25% glycerol.
• Shipping: Dry ice

Gene Information

• Gene Name: PAK2 p21 (RAC1) activated kinase 2 [ Homo sapiens (human) ]
• Official Symbol: PAK2
• Synonyms: PAK2; p21 (RAC1) activated kinase 2; PAK65; PAKgamma; serine/threonine-protein kinase PAK 2; PAK-2; S6/H4 kinase; gamma-PAK; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p58; EC 2.7.11.1
• Gene ID: 5062
• mRNA Refseq: NM_002577
• Protein Refseq: NP_002568
• MIM: 605022
• UniProt ID: Q13177