Human PAK2 Knockdown Cell Lysate

• Cat.No.: PAK2-260HKCL
• Product Overview: WB-validated PAK2 Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 58 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg PAK2 KD HeLa cell lysate
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Axon guidance, ErbB signaling pathway, Focal adhesion, MAPK signaling pathway, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 [ Homo sapiens (human) ]
• Official Symbol: PAK2
• Synonyms: PAK2; p21 protein (Cdc42/Rac)-activated kinase 2; p21 (CDKN1A) activated kinase 2; serine/threonine-protein kinase PAK 2; PAK65; PAKgamma; S6/H4 kinase; p58; PAK-2; gamma-PAK; p21-activated kinase 2; p21 (CDKN1A)-activated kinase 2
• Gene ID: 5062
• mRNA Refseq: NM_002577
• Protein Refseq: NP_002568
• MIM: 605022
• UniProt ID: Q13177