Recombinant Human P21 Protein (Cdc42/Rac)-Activated Kinase 2

• Cat.No.: PAK2-521H
• Product Overview: Recombinant Human PAK2 (amino acids 227-524) was expressed inE.coli.MW=33.5 kDa.

Specification

• Cat. No.: PAK2-521H
• Description: Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene. The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
• Source: E.Coli.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol, and 5 mM DTT.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Stability: >6 months at -80°C.

Gene Information

• Gene Name: PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 [ Homo sapiens ]
• Synonyms: p21 protein (Cdc42/Rac)-activated kinase 2; PAK65; PAKgamma; PAK2; p21-activated kinase 2; S6/H4 kinase; p21 (CDKN1A)-activated kinase 2; EC 2.7.11.1; PAK-2; Gamma-PAK; p58
• Gene ID: 5062
• mRNA Refseq: NM_002577
• Protein Refseq: NP_002568
• MIM: 605022
• UniProt ID: Q13177
• Chromosome Location: 3q29
• Pathway: Axon guidance; ErbB signaling pathway; Focal adhesion; MAPK signaling pathway; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway
• Function: ATP binding; identical protein binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity