pax8
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  • Official Full Name
  • paired box 8
  • Background
  • This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family;typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This;nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations;in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular;thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms
  • PAX8; paired box 8; paired box gene 8; paired box protein Pax-8; paired domain gene 8
Cat.#:PAX8-29058THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PAX8
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Cat.#:PAX8-451HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAX8, His tagged
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Cat.#:PAX8-675HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human paired box 8, His-tagged
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Cat.#:PAX8-12397MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PAX8 Protein
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Cat.#:PAX8-4285RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PAX8 Protein
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Cat.#:PAX8-3412HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAX8 293 Cell Lysate
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Involved Pathway

PAX8 involved in several pathways and played different roles in them. We selected most pathways PAX8 participated on our site, such as Thyroid hormone synthesis, Pathways in cancer, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Thyroid hormone synthesis
ASGR2; TPO; PRKACA; ITPR1; GPX6; PLCB1; PDIA4; GPX2; ITPR3; ATP1A4
Pathways in cancer
RARA; PRKCA; RALB; RAC3; TRAF1; SMAD4; RASSF1; FZD1; NOS2; PDGFB
Transcriptional misregulation in cancer
HIST2H3C2; ATF1; HIST1H3H; Itgam&Itgb2; EYA1; RUNX2; TAF15; MLLT1; HIST1H3D; FEV
Thyroid cancer
TP53; NCOA4; RET; TRP53; CCDC6; NTRK1; RXRG; KRAS; MAPK1; MAP2K2

Protein Function

PAX8 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX8 itself. We selected most functions PAX8 had, and list some proteins which have the same functions with PAX8. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZFP579; TRP53; MAFBB; CENPA; RORAA; VDR; ZFP64; PHOX2BB; FOXJ1; CLOCKA
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein TFAM; PAX5; ELF4; Ar; H2AFZ; POU2F2; BCL11B; SOX1; TGIF1; ZNF100
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein NR4A2; SMAD5; SOX11; NSD1; SOX8; TFAP2B; PAX6; MTF1; ZNF277; RREB1
Function protein binding
Related Protein MICA; SIT1; CCDC6; RELB; RBFA; RPS14; PAIP1; TRPC5; PLSCR3; TCHP
Function thyroid-stimulating hormone receptor activity
Related Protein TSHR; PAX8
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZFP35; TBX5A; SOX11B; ZNF205; UBN2A; ZNF192; PPARDB; NR2F5; OTX1A; NR1I3
Function transcription regulatory region DNA binding
Related Protein ZNF821; TCF7; GABPB1; HDAC1; GLIS2; KCNA3; TRP63; SMAD6; IKZF4; BCL11AA
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein FOXJ2; ELF1; HLTF; RELA; TLX1; EBF3A; EBF1; NR4A2; PITX3; ELF3

Interacting Protein

PAX8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX8.
SERINC1; CLSTN1; RPLP2; RB1; HSPA1A; NCL; ANXA7; RSBN1; TMA16; UNK; CHUK; PKM; CXCL9; e2f1_human_gene

PAX8 Related Articles

Conant, J; DeSarno, M; et al. Positive PAX8 Staining In Lymphoid Neoplasms Depends on Target of Antibody. MODERN PATHOLOGY 28:498A-498A(2015).
Conant, J; DeSarno, M; et al. Positive PAX8 Staining In Lymphoid Neoplasms Depends on Target of Antibody. LABORATORY INVESTIGATION 95:498A-498A(2015).