Recombinant Full Length Human PAX8 Protein, C-Flag-tagged

• Cat.No.: PAX8-385HFL
• Product Overview: Recombinant Full Length Human PAX8 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 48 kDa
• AA Sequence: MPHNSIRSGHGGLNQLGGAFVNGRP LPEVVRQRIVDLAHQGVRPCDISRQ LRVSHGCVSKILGRYYETGS IRPGVIGGSKPKVATPKVVEKIGDY KRQNPTMFAWEIRDRLLAEGVCDND TVPSVSSINRIIRTKVQQPF NLPMDSCVATKSLSPGHTLIPSSAV TPPESPQSDSLGSTYSINGLLGIAQ PGSDKRKMDDSDQDSCRLSI DSQSSSSGPRKHLRTDAFSQHHLEP LECPFERQHYPEAYASPSHTKGEQG LYPLPLLNSTLDDGKATLTP SNTPLGRNLSTHQTYPVVADPHSPF AIKQETPEVSSSSSTPSSLSSSAFL DLQQVGSGVPPFNAFPHAAS VYGQFTGQALLSGREMVGPTLPGYP PHIPTSGQGSYASSAIAGMVAGSEY SGNAYGHTPYSSYSEAWRFP
  NSSLLSSPYYYSSTSRPSAPPTTAT AFDHLTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Pathways in cancer, Thyroid cancer

Gene Information

• Gene Name: PAX8 paired box 8 [ Homo sapiens (human) ]
• Official Symbol: PAX8
• Synonyms: PAX-8
• Gene ID: 7849
• mRNA Refseq: NM_003466.4
• Protein Refseq: NP_003457.1
• MIM: 167415
• UniProt ID: Q06710