pik3r1
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • Background
  • Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The;enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the;85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin,;and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in;four transcript variants encoding different isoforms.
  • Synonyms
  • PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphatidylinositol 3-kinase regulatory subunit alpha; GRB1; p85; p85 ALPHA; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphati
Cat.#:PIK3R1-4934HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3R1 Protein, His-tagged
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Cat.#:PIK3CA/PIK3R1-389HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1, His-tagged, Active
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Cat.#:PIK3CA/PIK3R1-631HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1, FLAG-tagged
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Cat.#:PIK3CA/PIK3R1-641HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1
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Cat.#:PIK3CB/PIK3R1-391HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CB/PIK3R1, His-tagged, Active
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Cat.#:PIK3CB/PIK3R1-632HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CB/PIK3R1, FLAG-tagged
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Cat.#:Pik3ca/PIK3R1-390HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Mouse, Human
Product nameRecombinant Mouse and Human Pik3ca/PIK3R1, His-tagged, Active
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Cat.#:PIK3R1&Pik3ca-155HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA and Mouse Pik3ca protein, His-tagged, Active
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Cat.#:PIK3R1&PIK3CD-157HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3R1/PIK3CD protein, His-tagged, Active
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Cat.#:PIK3R1-1079HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3R1, His-tagged
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Cat.#:PIK3R1-29588THTag:His
Source (Host):Species:Human
Product nameRecombinant Human PIK3R1, His-tagged
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Cat.#:PIK3R1-29688THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CA, His-tagged
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Cat.#:PIK3R1-31096THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CB, His-tagged
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Cat.#:PIK3R1-315HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R1 protein, His/MBP-tagged
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Cat.#:PIK3R1-316HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2 protein, His/MBP-tagged
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Cat.#:PIK3R1-31767THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CB, His-tagged
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Cat.#:PIK3R1-4864HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha), His-tagged
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Cat.#:PIK3R1-4463RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIK3R1 Protein
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Cat.#:PIK3R1-3434RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R1 Protein, His-tagged
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Cat.#:PIK3R1-8346ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3R1
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Cat.#:PIK3R1-05BTag:N/A
Source (Host):Leishmania tarentolaeSpecies:Bovine
Product nameRecombinant Bovine PIK3R1
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Cat.#:PIK3R1-06BTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine PIK3R1
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Cat.#:PIK3R1-3185HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3R1 293 Cell Lysate
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Involved Pathway

PIK3R1 involved in several pathways and played different roles in them. We selected most pathways PIK3R1 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
BADB; NCK2A; CAMK2A; GRB2A; PRKCG; HBEGFA; CBL; CAMK2D1; CDKN1BB; GRB2B
Ras signaling pathway
PDGFRB; BCL2L1; PLA2G4A; ARF6; PLA2G2A; RASAL1; SHC1; FGF14; Fasl; RAP1A
Rap signaling pathway
FGF7; PIK3R1; FGF12; MAGI1; KRIT1; FGF5; SKAP1; KITLG; CALM3; GNAI1
cGMP-PKG signaling pathway
CREB3L1; Adcy4; SLC25A6; SLC25A5; ROCK2; PRKCE; MYLK3; MEF2D; NPPB; PDE3A
cAMP signaling pathway
NFKBIA; MAP2K2; SLC9A1; MAP2K1; CAMK2D; PLD2; ATP2A2; PAK1; MAPK1; PIK3R2
Chemokine signaling pathway
GM10591; CCL16; CCL8; RHOA; PIK3R1; PTK2B; XCL2; CXCL16; STAT3; CCL18
HIF- signaling pathway
MKNK2; PLCG1; LDHA; MAPK3; ENO1; PDHB; PDK1; NOX1; ANGPT1; IL6
FoxO signaling pathway
TGFBR1; HOMER1B; KLF2B; AKT1; PDPK1B; BNIP4; PRKAA1; PRMT1; AKT2L; AKT3A
Phosphatidylinositol signaling system
PIK3R3A; MTMR7B; IMPA2; CALM3; PIK3CD; INPP5B; PI4K2B; PLCD1; PIK3CB; PLCD3A
Sphingolipid signaling pathway
GAB2; AKT2; LASS1; TP53; SPTLC1; AKT1; MAP2K2; PLCB1; MAP2K1; GNAI2
Phospholipase D signaling pathway
PTK2B; CXCR2; PPAP2C; GRM5; AGTR1B; RALB; TSC2; PLCB3; MAPK3; PTGFR
mTOR signaling pathway
TSC1A; PRKCA; VEGFAB; PIK3R3A; MAPK3; RPS6KB1; AKT1S1; AKT3A; PIK3R5; ULK1
PIK-Akt signaling pathway
TCL1B4; Gh; BCL2L1; GNB1; PDGFA; ITGAV; LPAR6; Il4ra; COL4A1; IFNA13
AMPK signaling pathway
RPS6KB1; SIRT1; Scd1; FOXO3; ACACA; EEF2K; ADIPOR2; CPT1C; PPP2R5A; CREB3
Apoptosis
PIK3R2; PRKACA; STK26; CTNNB2; RELA; GZMF; PRKACAA; DIABLOA; PIK3CB; TRADD
Adrenergic signaling in cardiomyocytes
ADCY1B; PIK3R5; CREB3L3L; ADCY6; CACNG8; SCN1BA; PPP1CA; ATP1B3; PPP2R5D; CREM
VEGF signaling pathway
RAC1; MAP2K2A; PPP3CCB; PRKCB; PIK3CD; PIK3CG; PPP3R2; RAC3B; VEGFAA; CDC42L
Osteoclast differentiation
FCGR1A; CAMK4; TNFRSF11A; PIK3R5; IFNAR2; TYK2; TYROBP; LILRB1; IKBKG; STAT2
Focal adhesion
MYL10; THBS2; TNW; VTN; PDGFC; MLCK2; MAPK3; PXNA; PAK3; ITGB3B
Signaling pathways regulating pluripotency of stem cells
HOXB1; FGFR4; PIK3R3; ID1; KLF4; ID3; FZD1; WNT4; PCGF2; WNT5B
Platelet activation
PLA2G4C; F2R; FCER1G; ITGA2B; NOS3; PLCG2; PIK3R1; GP5; PRKCI; MYLK2
Toll-like receptor signaling pathway
TICAM2; TLR2-1; IKBKE; IFNPHI3; IKBKB; Ifna11; PIK3R3; MAP2K1; MAP2K3; CD80
Jak-STAT signaling pathway
CRFB2; IL28A; IL2RG; IFNK; PIAS1; IFNGR2; Gh; IL21R; GHRA; IL10RA
Natural killer cell mediated cytotoxicity
TNFRSF10C; IFNA17; NRAS; KIR2DS4; RAET1L; ULBP1; RAC1; PLCG2; PRKCA; RAET1G
T cell receptor signaling pathway
MAPK12; RHOA; CABIN1; VAV1; PDCD1; PTPN6; CD28; ZAP70; GRB2; VAV3
B cell receptor signaling pathway
NFKBIA; STAP1; RASGRP3; VAV2; PLCG2; NFKBIB; ARPC1B; BCL10; IFITM1; CD72
Fc epsilon RI signaling pathway
MAPK9; MS4A2; FCER1G; PLA2G4F; IL13; MAP2K6; FCER1A; GAB2; GRB2; RAF1
Fc gamma R-mediated phagocytosis
AKT2; PLA2G4D; ARPC5L; CFL1; PPAP2A; RAC2; PIK3CA; VAV3; MAPK3; SYK
TNF signaling pathway
CREB3L2; PGAM5; AKT1; MAP3K5; BIRC3; MAP2K4; TRAF2; NFKB1; TNFAIP3; DNM1L
Leukocyte transendothelial migration
ACTN3; ITGB2; CLDN8; ARHGAP35; EZR; MYL9; VCL; MMP9; CLDN3; NIPAL1
Neurotrophin signaling pathway
MAGED1; MAP2K1; MAP3K1; BAD; ATF4; MATK; MAPK10; CALM2; IRS1; MAPK11
Cholinergic synapse
MAPK3; AKT1; GNB3; CREB3; GNG8; KCNQ3; CHRM1; CREB3L4; PRKCG; GNGT1
Inflammatory mediator regulation of TRP channels
PPP1CB; PRKCG; ASIC4; CYP2J2; CYP2C54; ASIC5; CYP2C70; ACCN4; CALM4; TRPV1
Regulation of actin cytoskeleton
PIK3CA; PIP5K1BB; ARHGEF4; VAV3; RAF1B; RHOAC; ITGB8; HRASB; FGF16; ROCK1
Insulin signaling pathway
MAP2K1; GSK3AA; FLOT2B; PRKAR2A; HRAS; RAF1A; SOCS3B; HK2; PRKAB1B; CALM1A
Progesterone-mediated oocyte maturation
RPS6KAL; MAPK8; PDE3B; MAPK8A; MAPK12; PRKACAB; GNAI3; CDC27; BUB1; ADCY2B
Estrogen signaling pathway
SHC1; HSPA2; PIK3R2; CREB5; FKBP4; KRAS; Adcy4; ESR2; CALM2; PIK3CB
Prolactin signaling pathway
RAF1; PIK3R3; MAPK12; GRB2; SOCS3; SHC1; SOCS2; STAT5B; INS1; FOS
Thyroid hormone signaling pathway
RCAN1; MED13; FXYD2; MED12; SRC; MAP2K2; ATP1B2; TP53; BMP4; RXRB
Oxytocin signaling pathway
PPP3R1; CACNG4; MAP2K5; MAPK1; PLCB1; CACNA2D2; CAMK2D; CACNG6; PLA2G4F; PIK3R5
Regulation of lipolysis in adipocytes
FABP4; PTGS1; PIK3CB; PIK3R2; TSHB; AQP7; NPR1; PRKG1; PIK3CG; PTGER3
Type II diabetes mellitus
INSR; PKLR; PRKCD; INS-IGF2; MAPK10; SOCS2; TNF; IRS2; SLC2A2; SOCS1
Insulin resistance
PDPK1B; MAPK8B; PRKAB1B; PTENB; INS; PPP1CC; NR1H2; AKT2L; INSRA; NOS3
Non-alcoholic fatty liver disease (NAFLD)
ADIPOQ; SOCS3; RXRA; NDUFA1; PIK3R3; AKT1; IKBKB; IL6; NDUFA2; LEP
Aldosterone-regulated sodium reabsorption
ATP1A2; PIK3R2; NEDD4L; SGK1; PRKCA; ATP1B3; PIK3CG; SCNN1G; HSD11B2; SLC9A3R2
Carbohydrate digestion and absorption
PIK3R5; HKDC1; SLC37A4; SLC2A5; PIK3CD; ATP1A4; HK2; G6PC; PIK3R2; TAS1R2
Bacterial invasion of epithelial cells
ARPC5; PIK3R3; DNM2; FN1; SEPT1; CD2AP; WASF2; SEPT11; RHOG; DOCK1
Chagas disease (American trypanosomiasis)
TGFB2; PLCB3; PIK3CG; BDKRB2; Fasl; PLCB4; GNAI2; CCL2; MAP2K4; MAPK13
Toxoplasmosis
PIK3R5; TGFB1; ITGB1; HLA-DRA; TGFB2; IL10RB; Casp3; GNAI3; TNFRSF1A; IRGM1
Amoebiasis
SERPINB9; LAMB2; PLCB4; ACTN4; GNA14; PIK3R1; GNAS; COL4A6; CSF2; NOS2
Hepatitis C
MAPK1; SOCS3; TRADD; IFNAR2; CLDN17; PIK3CD; AKT1; STAT1; PIAS1; Ifna15
Hepatitis B
TNF; CASP10; STAT5B; IL-8; IFNA12; TIRAP; MAP2K4; IFNA14; TGFBR1; CASP12
Measles
GSK3B; MSN; IFNA10; CD209C; TRP53; OAS1; STAT1; IL13; CBLB; TYK2
Influenza A
CPSF4; DDX58; IFNB1; MAP2K3; MYD88; LOC100033925; IFNA8; IL12B; IFNA2; TNFRSF10D
HTLV-I infection
TSPO; WNT5B; CREM; EP300; LCK; PIK3R3; HLA-DPA1; BUB1B; PIK3R5; RANBP1
Epstein-Barr virus infection
PSMD2; TYK2; CD19; ENTPD3; YWHAH; STAT3; YWHAE; NFKB2; CDK1; TRAF6
Pathways in cancer
NRAS; FGFR1; AGTR1B; FGF13; VEGFA; GSTP1; VEGFB; BAD; GNAQ; LEF1
Viral carcinogenesis
C3; RBL1; SCIN; TBP; HIST1H2BK; PIK3CD; PSMC1; GTF2A1L; TP53; TRAF2
Proteoglycans in cancer
MMP9; ARHGEF12; WNT8A; RHOA; FZD8; WNT4; HOXD10; AKT2; PIK3CG; PIK3CA
Colorectal cancer
SMAD4; TCF7L2; MAPK9; PIK3R1; PIK3CD; RAC1; LEF1; BAD; MLH1; TGFB2
Renal cell carcinoma
TGFB2; FH1; AHA-1; VHL; RAPGEF1; AKT1; PAK6; HGF; PDGFB; RAP1B
Pancreatic cancer
RAC1; RAC3; CCND1; STAT1; VEGFA; RALB; BRCA2; SMAD3; RAC2; BRAF
Endometrial cancer
ERBB2; PIK3R2; CDH1; TCF7L2; CASP9; GSK3B; AKT2; MAPK3; AXIN2; NRAS
Glioma
CAMK2B; PIK3R2; MAPK3; CALM3; PIK3R1; BRAF; CAMK2D; PIK3CD; GRB2; NRAS
Prostate cancer
PIK3R3; NOXA1; TCF7; FOXO1; BRAF; KRAS; MAP2K1; IKBKB; MDM2; FGFR1
Melanoma
PIK3CB; Pdgfa&Pdgfb; FGF17; FGF2; FGF19; PIK3CG; IGF1; CCND1; FGF7; MAP2K1
Chronic myeloid leukemia
PIK3R2; SHC4; MAP2K2; CRK; TGFBR2; PIK3R1; MAPK3; SHC2; AKT2; BCR
Acute myeloid leukemia
IKBKB; RPS6KB2; PIK3R1; GRB2; STAT5B; MAPK3; IKBKG; RUNX1T1; PIK3CD; AKT3
Small cell lung cancer
CKS2; PIK3CB; FHIT; ITGB1; AKT2; PIK3CA; PIK3CG; ITGA3; LAMC1; COL4A1
Non-small cell lung cancer
AKT2; PIK3CD; PIK3R3; RAF1; TGFA; PRKCA; SOS1; RARB; CCND1; KRAS
Central carbon metabolism in cancer
TP53; SLC16A3; HK3; PFKM; HK2; NTRK3; PFKL; MAP2K2; RET; SLC7A5
Choline metabolism in cancer
DGKG; PIK3R1; HRAS; SLC22A2; PRKCA; PRKCG; PIK3CD; PLA2G4F; PLA2G4D; LYPLA1

Protein Function

PIK3R1 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity, ErbB-3 class receptor binding, insulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R1 itself. We selected most functions PIK3R1 had, and list some proteins which have the same functions with PIK3R1. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein PIK3R1; PIK3R5; PIK3R3; PIK3R3B; PIK3R2; CCKBR; PIK3R6; PIK3R3A
Function ErbB-3 class receptor binding
Related Protein PIK3R1; ERBB2; NRG1; CDK5
Function insulin binding
Related Protein INSR; IGF1R; HSPD1; C2CD2L; IDE; PIK3R1
Function insulin receptor binding
Related Protein FRS3; DOK1B; INSL3; FRS2; IRS2; DOK2; PIK3R1; DOK5; IGF1; DOK3
Function insulin receptor substrate binding
Related Protein PIK3R1; PIK3CA; PTPN11; INSRB; IGF1RB; JAK2; INSRA; IGF1R; GRB2; PRKCZ
Function insulin-like growth factor receptor binding
Related Protein GNAS; REN; IGF2; YWHAH; IGF2B; IRS1; YWHAG; PIK3R1; Ren1; INS
Function neurotrophin TRKA receptor binding
Related Protein SHC1; PLCG1; NGFR; PIK3R1; EFNA5; FRS2; GRB2
Function phosphatidylinositol 3-kinase binding
Related Protein TYRO3; FYN; CALM2; CALM1; BECN1; IRS4; INSR; FLT3; CORO1A; JAK2
Function phosphatidylinositol 3-kinase regulator activity
Related Protein PIK3R1; PIK3R3A; KLF4; AGAP2; PIK3R3B
Function phosphatidylinositol 3-kinase regulatory subunit binding
Related Protein XBP1; PIK3R1; DNM2; FAM83A; PTPN13; PIK3AP1; FAM83B
Function protein binding
Related Protein PSKH1; LIN28B; RPL9; DCX; DYNC2LI1; PAG1; TIMM10; HMOX2; SKA3; ELMO3
Function protein heterodimerization activity
Related Protein TLR6; KCNA3; ABCG8; DRD1A; HIST1H47; CUL3; BCL2A1A; ADD2; BAXA; BOKA
Function protein phosphatase binding
Related Protein STAT6; DLG4; VCP; CDH5; TRP53; PPME1; PPP6R1; PPP6R3; TRAF3; DRD1A
Function transcription factor binding
Related Protein CTNNB1; ZFPM2; NR0B2A; HMGA1-RS1; E2F5; PSMC5; POU5F1; SOST; HMGB1; NKX2-1
Function transmembrane receptor protein tyrosine kinase adaptor activity
Related Protein FRS2; STAP1; DOK2; IRS1; PIK3R1; BLNK; GAB2; SHC1; SH2B2; TRAT1

Interacting Protein

PIK3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R1.
PDGFRB; CBL

PIK3R1 Related Articles

Deau, MC; Heurtier, L; et al. A human immunodeficiency caused by mutations in the PIK3R1 gene. JOURNAL OF CLINICAL INVESTIGATION 124:3923-3928(2014).
Sood, A; McClain, D; et al. PTEN Gene Expression and Mutations in the PIK3CA Gene as Predictors of Clinical Benefit to Anti-Epidermal Growth Factor Receptor Antibody Therapy in Patients With KRAS Wild-Type Metastatic Colorectal Cancer. CLINICAL COLORECTAL CANCER 11:143-150(2012).