pik3r1
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • Background
  • Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The;enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the;85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin,;and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in;four transcript variants encoding different isoforms.
  • Synonyms
  • PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphatidylinositol 3-kinase regulatory subunit alpha; GRB1; p85; p85 ALPHA; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphati
Cat.#:PIK3R1-4934HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3R1 Protein, His-tagged
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Cat.#:PIK3CA/PIK3R1-389HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1, His-tagged, Active
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Cat.#:PIK3CA/PIK3R1-631HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1, FLAG-tagged
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Cat.#:PIK3CA/PIK3R1-641HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1
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Cat.#:PIK3CB/PIK3R1-391HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CB/PIK3R1, His-tagged, Active
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Cat.#:PIK3CB/PIK3R1-632HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CB/PIK3R1, FLAG-tagged
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Cat.#:Pik3ca/PIK3R1-390HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Mouse, Human
Product nameRecombinant Mouse and Human Pik3ca/PIK3R1, His-tagged, Active
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Cat.#:PIK3R1&Pik3ca-155HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA and Mouse Pik3ca protein, His-tagged, Active
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Cat.#:PIK3R1&PIK3CD-157HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3R1/PIK3CD protein, His-tagged, Active
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Cat.#:PIK3R1-1079HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3R1, His-tagged
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Cat.#:PIK3R1-29588THTag:His
Source (Host):Species:Human
Product nameRecombinant Human PIK3R1, His-tagged
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Cat.#:PIK3R1-29688THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CA, His-tagged
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Cat.#:PIK3R1-31096THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CB, His-tagged
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Cat.#:PIK3R1-315HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R1 protein, His/MBP-tagged
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Cat.#:PIK3R1-316HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2 protein, His/MBP-tagged
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Cat.#:PIK3R1-31767THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CB, His-tagged
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Cat.#:PIK3R1-4864HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha), His-tagged
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Cat.#:PIK3R1-4463RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIK3R1 Protein
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Cat.#:PIK3R1-3434RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R1 Protein, His-tagged
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Cat.#:PIK3R1-8346ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3R1
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Cat.#:PIK3R1-05BTag:N/A
Source (Host):Leishmania tarentolaeSpecies:Bovine
Product nameRecombinant Bovine PIK3R1
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Cat.#:PIK3R1-06BTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine PIK3R1
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Cat.#:PIK3R1-3185HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3R1 293 Cell Lysate
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Involved Pathway

PIK3R1 involved in several pathways and played different roles in them. We selected most pathways PIK3R1 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
GRB2; MAPK3; RPS6KB1B; NCK2; BRAF; PLCG1; MAPK8B; NCK2A; BADB; AREG
Ras signaling pathway
GNG10; GNB2; ETS1; RASSF1; MAPK3; RGL2; ZAP70; HRAS; FGF9; VEGFA
Rap signaling pathway
SIPA1L2; ANGPT4; ARAP3; RRAS; LAT; PLCB3; ITGA2B; PFN1; PDGFRA; LCP2
cGMP-PKG signaling pathway
MEF2A; PLCB4; INS2; ATP2B4; KCNMB4; PIK3R1; NFATC3; IRS1; NPR1; CALM1
cAMP signaling pathway
HCAR3; VAV1; TNNI3; MAPK8; CALM4; PIK3R5; GRIN2C; GRIN2B; RAP1A; HTR6
Chemokine signaling pathway
CCR7; PRKCZ; FGR; XCR1; Cxcl15; GNGT1; PLCB3; PIK3CB; CCL26; PIK3R3
HIF- signaling pathway
PLCG1; IGF1; IFNG; VEGFA; HMOX1; CAMK2G; Il6ra; TFRC; PIK3CD; IFNGR1
FoxO signaling pathway
NRAS; CAT; GRB2; INSRB; GADD45G; SMAD3; KLF2A; G6PCA.1; PRKAB1A; PIK3R3B
Phosphatidylinositol signaling system
PI4KAA; PTENA; MTMR1; MTMR6; INPP5B; MTMR1A; MTMR4; INPP1; CALM3A; PTENB
Sphingolipid signaling pathway
FYN; SGPP1; LASS5; ACER1; BDKRB2; PPP2R1B; RAC2; PPP2R2C; TRP53; NRAS
Phospholipase D signaling pathway
AGTR1B; PLCB3; CXCR2; INS1; PTGFR; PIK3CD; GRM3; RAF1; GRM7; GRM8
mTOR signaling pathway
PRKCA; MAPK1; INS1; PIK3R1; PRKAA2; PIK3CD; DEPDC6; RPS6; TSC2; PRKCBA
PIK-Akt signaling pathway
GNG5; LAMA4; ITGB1; NOS3; BRCA1; PIK3CB; FGF8; FASLG; GSK3B; LPAR5
AMPK signaling pathway
RAB2A; Scd2; CCNA2; EEF2K; PPP2CA; CRTC2; LEP; CREB3L3; CREB3; ACACA
Apoptosis
NFKB1; GAS2; DBNLB; CASP6L2; IRF1B; CASP2; BADB; ATM; TNFRSF10B; IRAK1
Adrenergic signaling in cardiomyocytes
CAMK2G; TNNC1A; CACNA2D3; AGTR1; AGTR1B; PPP2R5D; PPP2R5B; ADRA1D; RAPGEF4; GNAIA
VEGF signaling pathway
PPP3CA; SHC2; PIK3R1; RAF1B; PIK3CD; MAP2K2B; MAPK12B; PXNA; PTGS2; MAPK14A
Osteoclast differentiation
TYK2; IFNAR1; NCF4; FCGR1A; NFATC1; SOCS1; IFNB1; RAC1; TAB2; FOSL2
Focal adhesion
RHOAB; CCND1; FN1; ILK; TNK2; VEGFAB; ITGA1; PIK3R3A; AKT2; LAMB2
Signaling pathways regulating pluripotency of stem cells
FGFR4; ID2; WNT3; PIK3R5; HESX1; SMAD5; SMAD1; PIK3CG; MEIS1; PIK3CB
Platelet activation
PIK3R2; MYL12B; FGG; ITGA2; ITGA2B; MYLK2; ACTB; BTK; PIK3CD; PRKG2
Toll-like receptor signaling pathway
TLR9; IFNAR1; MAP2K4; AKT2; CXCL11; RIPK1L; IFNA12; NFKBIA; CD86; PIK3CG
Jak-STAT signaling pathway
EPO; IL20; PIK3CB; CRFB2; IFNA2; AOX3; IL13; STAT2; IL17D; IL11
Natural killer cell mediated cytotoxicity
Ifna11; FCGR3A; FCGR3B; PPP3CB; IFNA6; PLCG1; Raet1a; PIK3R3; SHC3; LCP2
T cell receptor signaling pathway
NFATC2; PIK3R3; TNF; PAK7; KRAS; PLCG1; DBNLB; SLA1; CBLB; DEF6A
B cell receptor signaling pathway
MALT1; DOK3; MAP2K2; CR2; CD22; PLEKHA2; PLEKHA1; BCL2L11; TTC6; NFATC3
Fc epsilon RI signaling pathway
VAV1; LAT; RAC2; PIK3CD; PIK3R3; PLA2G4B; MAP2K3; PDPK1; IL4; MAP2K6
Fc gamma R-mediated phagocytosis
PLA2G4A; SYK; PIK3R2; MAPK1; PAK1; FCGR3A; HCK; PPAP2B; PIK3R3; ARPC5L
TNF signaling pathway
MAPK13; MAP2K3; MAP3K7IP3; RPS6KA5; TRAF1; BIRC3; VCAM1; SOCS3; CXCL10; VEGFC
Leukocyte transendothelial migration
CLDN11; PIK3R1; CLDN10; Itgam&Itgb2; ITGB1; GNAI2; RAP1B; PIK3CG; PTK2B; ACTN2
Neurotrophin signaling pathway
CAMK2G; TP53; NFKB1; AKT2; PRKCD; FASLG; IRAK4; IRAK1; MAPK12; RHOA
Cholinergic synapse
GNG2; PIK3R5; AKT2; PLCB3; KCNQ3; CHRM3; SLC5A7; AKT1; CHAT; GNG4
Inflammatory mediator regulation of TRP channels
CAMK2A; NGF; PRKCG; CAMK2D; PLCB4; PLA2G4A; PIK3CD; CYP4A10; ASIC3; CALM3
Regulation of actin cytoskeleton
FGF22; MYLK; FGF1B; SCINLB; BDKRB1; MYL5; LIMK1A; BDKRB2; PAK6; FGD
Insulin signaling pathway
PRKACBA; INS; SOCS1; LIPE; MAPK9; PRKAR2AB; PPP1CA; RAPGEF1; PKLR; IKBKB
Progesterone-mediated oocyte maturation
CDH1-A; MOS; MAPK12; PRKACAA; CPEB4; ANAPC5; MAP2K1; MAPK10; INS2; PIK3CG
Estrogen signaling pathway
SOS1; FKBP4; AKT1; ITPR3; GABBR1; ESR2; KCNJ9; FKBP5; PIK3R5; Adcy4
Prolactin signaling pathway
PIK3CD; SOCS7; GRB2; SOCS2; PRL; IRF1; SIRPA; INS; LHB; SLC2A2
Thyroid hormone signaling pathway
RXRB; FOXO1; SRC; KAT2B; ATP1B4; THRA; MED30; RHEB; PRKCG; MAPK3
Oxytocin signaling pathway
MAP2K2; MYL9; CACNA2D4; CAMK2A; OXT; NPR2; CAMK1G; PLCB4; GUCY1B3; CACNB1
Regulation of lipolysis in adipocytes
NPY1R; IRS2; INS1; PRKG2; PNPLA2; LOC100328615; PTGER3; INS; FABP4; PIK3R3
Type II diabetes mellitus
PKM2; PIK3R1; SOCS2; PIK3R3; INS-IGF2; SOCS3; MAPK3; PIK3CG; IRS4; SOCS1
Insulin resistance
NFKB1; RPS6KA2; RELA; PIK3CA; GYS2; PTPN11; SLC27A5; CREB3L3L; SREBF1; PTPRFB
Non-alcoholic fatty liver disease (NAFLD)
Casp3; NDUFA10; UQCR10; DDIT3; CEBPA; BID; NDUFA3; XBP1; NDUFC2-KCTD14; IL6R
Aldosterone-regulated sodium reabsorption
NR3C2; FXYD2; NEDD4L; PIK3CA; INS; PIK3R1; PIK3CB; SCNN1B; PRKCA; KCNJ1
Carbohydrate digestion and absorption
PIK3R5; HK2; ATP1B4; AMY2B; PIK3R3; TAS1R2; FXYD2; G6PC2; SLC37A4; AMY2A3
Bacterial invasion of epithelial cells
DNM1; SEPT9; RHOA; CLTA; WASF1; DNM3; MAD2L2; SEPT1; ELMO3; DOCK1
Chagas disease (American trypanosomiasis)
TNFRSF1A; IL12B; IL1B2; C3; PIK3CA; MAPK11; MAPK8; FASLG; SMAD3; PPP2R2A
Toxoplasmosis
HSPA1B; TLR4; Toxoplasma Gondii Profilin Family Protein; HLA-DOB; RELA; TRAF6; HSPA1L; LAMC1; AKT2; PIK3R5
Amoebiasis
C8B; IL1B; ARG1; NFKB1; SERPINB1A; COL2A1; ARG2; COL3A1; COL5A1; SERPINB13
Hepatitis C
TRADD; IKBKG; EIF3E; CLDN17; MAPK1; CLDN16; MAPK9; IFNB1; OAS1; TLR3
Hepatitis B
TP53; IFNA4; BAD; ATP6AP1; MYD88; NFKB1; IKBKE; PIK3CD; DDX3X; NRAS
Measles
MSN; TLR2; PIK3R5; IFNA16; IKBKE; RAB9B; TNFRSF10B; CD209; STAT5B; TBK1
Influenza A
TRIM25; MAPK13; HLA-DRB1; STAT2; TMPRSS4; OAS1B; CASP1; TBK1; IL8L2; PRKCA
HTLV-I infection
ANAPC11; WNT8A; ANAPC5; IKBKG; PIK3CG; PIK3R2; KRAS; SLC25A5; BCL2L1; PRKACB
Epstein-Barr virus infection
YWHAZ; ICAM1; LYN; EP300; NCOR2; PLCG1; TP53; PRKACB; HLA-DRB1; ENTPD1
Pathways in cancer
GNAI3; FGF14; LPAR3; BDKRB1; RALB; ARNT2; TPM3; ROCK2; FGF12; PDGFRA
Viral carcinogenesis
PMAIP1; YWHAG; HDAC7A; BAX; PIK3CA; GTF2H2C_2; ACTN4; TRAF2; RBPJL; HIST1H4J
Proteoglycans in cancer
SDC2; ITGB3; WNT9A; WNT7B; PTPN11; RRAS2; PTCH1; PIK3CA; BRAF; PPP1R12C
Colorectal cancer
RAF1; RAC3; MAPK8; TGFBR1; BAD; MAPK10; APPL1; ARAF; SMAD2; PIK3R5
Renal cell carcinoma
TGFB2; PIK3R3; RBX1; PAK3; VEGFA; ARNT2; CDC42; CUL2; PDGFB; PAK7
Pancreatic cancer
PIK3CB; KRAS; PIK3R2; TRP53; PIK3R1; TGFBR1; PIK3CD; RAC2; AKT1; MAPK10
Endometrial cancer
FOXO3; ILK; MAP2K2; APC; AKT2; MAP2K1; PIK3CB; PIK3R2; PIK3R1; NRAS
Glioma
IGF1R; PLCG2; CALM1; CCND1; CALML3; PIK3R5; KRAS; PRKCB; CAMK2G; PRKCG
Prostate cancer
CREB5; RB1; CREB3L1; CPN1; PIK3CB; RELA; FGFR1; IGF1; PIK3R5; HSP90B1
Melanoma
FGF1; FGF7; PIK3CG; CDH1; FGF10; FGF19; FGF5; PIK3R1; FGF18; HRAS
Chronic myeloid leukemia
TGFB2; SMAD3; NFKBIA; PIK3R2; MAP2K2; HDAC1; SMAD4; PIK3CG; PIK3CA; TGFB1
Acute myeloid leukemia
RARA; RUNX1T1; GRB2; PIK3R3; PIK3R1; EIF4EBP1; RELA; PML; SOS1; TCF7L2
Small cell lung cancer
PTK2; XIAP; PIK3R2; BIRC2; LAMC2; RXRA; TRAF4; PIK3CB; MAX; TP53
Non-small cell lung cancer
GRB2; STK4; RB1; ARAF; RXRA; MAPK1; EML4; CCND1; PIK3R2; FHIT
Central carbon metabolism in cancer
FGFR2; PFKP; HK2; FGFR1; PFKM; MAPK3; GLS; IDH1; PDGFRB; PGAM1
Choline metabolism in cancer
SLC5A7; SLC22A1; PIK3R2; SLC22A5; GRB2; SLC44A1; PLA2G4C; SP1; MAPK3; PIP5K1C

Protein Function

PIK3R1 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity, ErbB-3 class receptor binding, insulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R1 itself. We selected most functions PIK3R1 had, and list some proteins which have the same functions with PIK3R1. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein PIK3R3; CCKBR; PIK3R6; PIK3R3B; PIK3R3A; PIK3R5; PIK3R1; PIK3R2
Function ErbB-3 class receptor binding
Related Protein PIK3R1; NRG1; CDK5; ERBB2
Function insulin binding
Related Protein IDE; PIK3R1; C2CD2L; IGF1R; INSR; HSPD1
Function insulin receptor binding
Related Protein IRS4; PTPN1; DOK2; IGF1; FRS2B; DOK1B; DOK4; PTPN11; FRS2; PIK3R1
Function insulin receptor substrate binding
Related Protein PTPN11; INSRB; PRKCD; PIK3CB; PIK3R1; PIK3CA; IGF1RA; INSRA; PRKCZ; IGF1R
Function insulin-like growth factor receptor binding
Related Protein PIK3R1; INS2; SHC1; SOCS1; IGF2; IGF3; IGF2B; IGF2A; Ren1; REN
Function neurotrophin TRKA receptor binding
Related Protein PLCG1; PIK3R1; EFNA5; FRS2; GRB2; NGFR; SHC1
Function phosphatidylinositol 3-kinase binding
Related Protein INSRR; IGF1RA; IRS2; HCST; LCK; CALM1; INSRA; CALM3; IGF1RB; DAB1
Function phosphatidylinositol 3-kinase regulator activity
Related Protein PIK3R3B; PIK3R3A; PIK3R1; KLF4; AGAP2
Function phosphatidylinositol 3-kinase regulatory subunit binding
Related Protein XBP1; FAM83B; FAM83A; PIK3AP1; PTPN13; PIK3R1; DNM2
Function protein binding
Related Protein GP9; CTC1; SPATA2; SLC14A2; YOD1; USP22; PIH1D3; CARD11; TGFBR2; POC5
Function protein heterodimerization activity
Related Protein ZBTB1; PPP3CA; PPARD; ZHX2; HIST1H2BF; OSTA; TOP2A; SOX9; FZD1; CENPA
Function protein phosphatase binding
Related Protein PPARG; ERBB2; PPP1R3G; PPP6R1; MAP3K5; DLG4; CSF1R; CDH5; FGF19; MVP
Function transcription factor binding
Related Protein TLE1; PPID; THRA; SLC26A5; TRIB2; NR0B2; PPARGC1A; HDAC5; FOXF2; LMO4
Function transmembrane receptor protein tyrosine kinase adaptor activity
Related Protein PIK3R1; GAB2; FRS2; IRS1; BLNK; TRAT1; SH2B2; STAP1; DOK2; SHC1

Interacting Protein

PIK3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R1.
PDGFRB; CBL

PIK3R1 Related Articles

Deau, MC; Heurtier, L; et al. A human immunodeficiency caused by mutations in the PIK3R1 gene. JOURNAL OF CLINICAL INVESTIGATION 124:3923-3928(2014).
Sood, A; McClain, D; et al. PTEN Gene Expression and Mutations in the PIK3CA Gene as Predictors of Clinical Benefit to Anti-Epidermal Growth Factor Receptor Antibody Therapy in Patients With KRAS Wild-Type Metastatic Colorectal Cancer. CLINICAL COLORECTAL CANCER 11:143-150(2012).