pik3r1
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • Background
  • Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The;enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the;85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin,;and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in;four transcript variants encoding different isoforms.
  • Synonyms
  • PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphatidylinositol 3-kinase regulatory subunit alpha; GRB1; p85; p85 ALPHA; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphati
Cat.#:PIK3R1-4934HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3R1 Protein, His-tagged
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Cat.#:PIK3CA/PIK3R1-389HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1, His-tagged, Active
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Cat.#:PIK3CA/PIK3R1-631HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1, FLAG-tagged
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Cat.#:PIK3CA/PIK3R1-641HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1
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Cat.#:PIK3CB/PIK3R1-391HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CB/PIK3R1, His-tagged, Active
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Cat.#:PIK3CB/PIK3R1-632HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CB/PIK3R1, FLAG-tagged
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Cat.#:Pik3ca/PIK3R1-390HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Mouse, Human
Product nameRecombinant Mouse and Human Pik3ca/PIK3R1, His-tagged, Active
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Cat.#:PIK3R1&Pik3ca-155HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA and Mouse Pik3ca protein, His-tagged, Active
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Cat.#:PIK3R1&PIK3CD-157HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3R1/PIK3CD protein, His-tagged, Active
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Cat.#:PIK3R1-1079HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3R1, His-tagged
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Cat.#:PIK3R1-29588THTag:His
Source (Host):Species:Human
Product nameRecombinant Human PIK3R1, His-tagged
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Cat.#:PIK3R1-29688THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CA, His-tagged
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Cat.#:PIK3R1-31096THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CB, His-tagged
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Cat.#:PIK3R1-315HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R1 protein, His/MBP-tagged
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Cat.#:PIK3R1-316HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2 protein, His/MBP-tagged
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Cat.#:PIK3R1-31767THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CB, His-tagged
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Cat.#:PIK3R1-4864HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha), His-tagged
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Cat.#:PIK3R1-4463RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIK3R1 Protein
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Cat.#:PIK3R1-3434RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R1 Protein, His-tagged
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Cat.#:PIK3R1-8346ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3R1
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Cat.#:PIK3R1-05BTag:N/A
Source (Host):Leishmania tarentolaeSpecies:Bovine
Product nameRecombinant Bovine PIK3R1
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Cat.#:PIK3R1-06BTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine PIK3R1
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Cat.#:PIK3R1-3185HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3R1 293 Cell Lysate
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Involved Pathway

PIK3R1 involved in several pathways and played different roles in them. We selected most pathways PIK3R1 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PRKCG; PRKCBB; NRAS; EGFRA; PIK3R1; PAK2; CDKN1BB; CBLC; PAK6; PLCG1
Ras signaling pathway
IKBKB; PIK3R5; GNG11; IGF1R; GNG10; PDGFC; RAP1B; INS1; CSF1; FGF6
Rap signaling pathway
GNAO1; FGF8; RAPGEF5; RASSF5; ITGA2B; ID1; TLN1; FGFR2; THBS1; PLCB4
cGMP-PKG signaling pathway
ATP1B4; Adcy4; GTF2IRD1; PLCB1; ATP2A1; PPP3R1; PPIF; CALM4; SLC25A31; AKT2
cAMP signaling pathway
SOX9; GRIN1; GRIA3; PIK3R2; DRD1A; RAP1A; HTR1B; PIK3CA; GPR81; PLN
Chemokine signaling pathway
GNG8; Ccl21a; GM13306; LYN; CXCL16; VAV3; CCR1L1; CXCL9; ARRB2; Ccl9
HIF- signaling pathway
EP300; MTOR; PDHB; ALDOA; NOX3; RELA; PDK1; MKNK2; MAP2K2; HK2
FoxO signaling pathway
GRB2B; HOMER1B; FOXO3A; CCND2A; INS1; ARAF; CDKN1BA; FBXO32; TGFBR1B; SGK2A
Phosphatidylinositol signaling system
PLCG2; PI4KA; PIK3CB; PPIP5K2; IPMKB; MTMR7; IP6K2; INPP1; INPP5K; TMEM55A
Sphingolipid signaling pathway
RHOA; MAP2K2; TP53; TRP53; PLCB3; LASS5; PTEN; PPP2R2D; PRKCG; PPP2R1A
Phospholipase D signaling pathway
PTPN11; SYK; AGPAT5; KRAS; INS1; KITLG; CYTH3; AGTR1A; RALB; GRM5
mTOR signaling pathway
RPS6KA2; DDIT4; STRADA; RRAGCB; RRAGC; PIK3R2; PRKCG; PIK3CA; RPS6KB1B; PRKAA1
PIK-Akt signaling pathway
YWHAG; RXRA; ITGB1; MAP2K1; F2R; GNG12; FGF6; PKN2; CASP9; NRAS
AMPK signaling pathway
RAB8A; PFKM; LEP; IGF1; HMGCR; CAMKK2; FOXO1; SLC2A4; IRS2; PIK3R2
Apoptosis
GZMC; MYC; CAPN2; DIABLOB; PPP3CC; CFLAR; BAXA; BCL2; YWHAQ; HRK
Adrenergic signaling in cardiomyocytes
CAMK2B1; PPP1CAB; CALML5; ATP1B3A; TMEM8C; AGTR1B; CALM1; CREM; PRKACB; AKT2
VEGF signaling pathway
PLCG2; SPHK2; PTGS2A; PIK3R3A; MAPKAPK2; PPP3CCA; RAC2; HRASB; MAPKAPK2A; PIK3R5
Osteoclast differentiation
CYBA; IKBKG; TNF; NOX3; MITF; TNFRSF11A; FCGR3; MAPK10; NFATC2; RELA
Focal adhesion
IGF1RA; ITGA1; TLN1; PAK2; PARVAA; ITGA11A; MAPK8; ITGB1B.2; SRC; BIRC2
Signaling pathways regulating pluripotency of stem cells
WNT10B; SMARCAD1; TBX3; HRAS; HOXB1; INHBB; MAPK12; SOX2; HAND1; ID1
Platelet activation
PLCB2; PLCB3; GP1BB; GP1BA; P2RY12; VASP; GNAI3; PIK3R2; GUCY1A3; ITPR3
Toll-like receptor signaling pathway
IFNA16; Ifna15; MAP2K2; MAPK8; CCL3L1; Ifna11; IFNA2; TLR8; CCL5; AKT3A
Jak-STAT signaling pathway
PIK3R1; Il23a; Il12b; IFNA12; IL10RA; IL19; STAT2; CSF3R; IFNA5; CRFB2; AOX3
Natural killer cell mediated cytotoxicity
ITGB2L; IFNA5; SH3BP2; BID; PRKCA; KLRC1; PIK3CA; LCP2; GZMB; ULBP3
T cell receptor signaling pathway
CD247; MAPK1; PAK6; SLA1; PRKCQ; DLG1; SOS1; NFATC2; PPP3CB; CD28
B cell receptor signaling pathway
NRAS; CD79A; RAC1; BCL10; PLCG2; RAP2A; MAP4K1; Cd79a, Cd79b; CDK4; CDK6
Fc epsilon RI signaling pathway
KRAS; MAP2K6; RAC3; RAC2; MAPK10; PIK3CG; INPP5D; PLCG2; TNF; MAPK1
Fc gamma R-mediated phagocytosis
PIK3CD; GSN; CFL2; PIK3R1; MAP2K1; PIK3CA; PIK3CB; VAV3; PLCG1; SPHK2
TNF signaling pathway
IL18R1; PIK3R5; PIK3CB; IL6; PTGS2; MMP14; IKBKB; CREB3L3; CXCL10; MAPK13
Leukocyte transendothelial migration
ACTB; PRKCB; PTK2; CLDN6; GNAI3; GNAI1; PLCG1; RHOH; MMP9; VASP
Neurotrophin signaling pathway
CALML5; CALML3; RELA; NTRK1; ARHGDIG; MAP3K5; MAP2K2; PIK3CD; NTRK3; NGF
Cholinergic synapse
PRKACG; FYN; CHRNA7; CHRNA6; ITPR1; MAPK3; Adcy4; GNAQ; KCNQ3; PIK3CB
Inflammatory mediator regulation of TRP channels
ALOX12; CYP2J6; PIK3CA; MAPK10; PRKCE; CYP2C37; PIK3R3; PTGER2; CALM3; TRPV1
Regulation of actin cytoskeleton
RHOAC; ARPC5LA; LIMK1A; EZR; VAV2; FGF12A; TMSB4X; NCKAP1L; ACTN4; ITGA10
Insulin signaling pathway
PIK3CG; GRB2B; PIK3CD; AKT2L; PRKAG1; AKT3A; PHKA2; TSC1; PPP1R3B; PIK3R3B
Progesterone-mediated oocyte maturation
FZR1A; MAPK8; PKMYT1; CCNB1; INS2; INS; MOS; MAD2L2; ANAPC4; PIK3R3
Estrogen signaling pathway
KRAS; GNAI1; PIK3CB; NRAS; PIK3R1; KCNJ5; CREB3L3; AKT1; PRKACG; SHC1
Prolactin signaling pathway
SOCS4; PRL; SIRPA; PIK3CB; TNFSF11; STAT5A; MAPK3; GALT; SHC4; STAT3
Thyroid hormone signaling pathway
MED30; NOTCH1; MED13; PLCB4; CCND1; MED24; PIK3R2; ATP1B4; MAPK3; PIK3CA
Oxytocin signaling pathway
MYL6; PLCB4; PIK3R5; PLA2G4F; GNAQ; CACNA2D3; ACTG1; CAMK2D; EEF2K; GNAS
Regulation of lipolysis in adipocytes
PRKACG; PLIN1; ABHD5; FABP4; Adcy4; INS2; PIK3R2; IRS4; PIK3CD; NPY1R
Type II diabetes mellitus
IRS2; PIK3CD; HK2; MAFA; MTOR; CACNA1G; SOCS2; HKDC1; PIK3CG; TNF
Insulin resistance
INSR; MAPK10; G6PC2; PTENA; AKT2L; PPARGC1A; PTENB; PPP1CBL; SLC2A4; NFKBIAB
Non-alcoholic fatty liver disease (NAFLD)
NDUFA5; NDUFB1; NDUFA7; TNF; UQCRH; NDUFB6; UQCRC1; MAPK8; PIK3R2; NDUFA1
Aldosterone-regulated sodium reabsorption
SCNN1B; PIK3CG; ATP1A2; PIK3CD; ATP1A1; PIK3CB; PDPK1; ATP1A3; PIK3R1; ATP1B4
Carbohydrate digestion and absorption
ATP1A3; PIK3R5; SLC2A2; PIK3CA; ATP1B3; SLC37A4; PIK3R3; ATP1A2; AMY1A; SLC5A1
Bacterial invasion of epithelial cells
PIK3R2; HCLS1; SEPT11; SHC1; PIK3R5; PIK3R3; DNM2; ARPC2; CRKL; PIK3CG
Chagas disease (American trypanosomiasis)
Fasl; IL12B; CCL2; CD3E; GNAI1; IL6; MAPK12; IRAK4; GNA15; CD3G
Toxoplasmosis
HLA-DRB1; NFKB1; IL12A; STAT3; STAT1; HSPA1A; CASP9; HLA-DRB4; LAMB4; MYD88
Amoebiasis
GNA14; LAMB2; ARG2; IL1R1; COL4A6; PTK2; SERPINB10; GNAQ; C8B; LAMB3
Hepatitis C
PPARA; PPP2CB; IFNA13; IFNA16; STAT1; DDX58; CLDN6; AKT2; IFNA6; MAPK3
Hepatitis B
MYD88; SRC; GRB2; TP53; PIK3R2; AKT1; IFNA8; CXCL8; CREB5; FADD
Measles
TLR7; EIF2AK1; MAP3K7; PIK3CD; IFNA14; PRKCQ; cgr2b; GSK3B; TNFRSF10A; SLAMF1
Influenza A
ACTG1; HLA-DRB3; PRSS3; HLA-DOB; FURIN; IFNA6; HLA-DRB5; IL18; IRF7; IL-8
HTLV-I infection
CRTC3; PCNA; WNT9B; STAT5B; SMAD2; Il2; DVL3; ANAPC1; HLA-DMB; TNF
Epstein-Barr virus infection
TYK2; TAB2; POLR3K; PSMD3; POLR2L; POLR2A; PSMD1; HLA-F; PIK3R2; CSNK2B
Pathways in cancer
EP300; PTCH2; PLEKHG5; CSF3R; ITGA2; MAP2K1; CCDC6; HDAC1; EGLN1; Flt3l
Viral carcinogenesis
HIST1H2BN; TRADD; HLA-F; HDAC9; PIK3CD; VDAC3; HIST1H2BF; HDAC8; GTF2H3; NFKB2
Proteoglycans in cancer
NANOG; TGFB1; FZD5; CAMK2A; MAPK12; WNT16; GPC1; FZD6; Fzd4; PTPN6
Colorectal cancer
MAPK10; TGFB2; AKT1; Casp3; BAX; RALGDS; DCC; MSH3; RAC2; TGFBR2
Renal cell carcinoma
TGFB1; PIK3CB; PIK3CG; GAB1; BRAF; MAPK1; SOS1; MAP2K2; EGLN1; HRAS
Pancreatic cancer
BCL2L1; PIK3R3; STAT1; KRAS; PIK3R1; TGFA; CDC42; BAD; STAT3; MAP2K1
Endometrial cancer
TP53; AXIN2; ERBB2; BRAF; RAF1; PTEN; CTNNA2; SOS1; PIK3R5; GSK3B
Glioma
CALM4; CAMK2G; SOS1; PIK3R3; IGF1; MAPK3; BRAF; MDM2; PRKCG; CALM1
Prostate cancer
MTOR; PDGFRB; FGFR1; NDRG1; TCF7; SOS1; NOXA1; IKBKB; SMARCA4; BRAF
Melanoma
FGF18; FGF10; MITF; FGF7; MDM2; MAPK3; MAP2K1; Pdgfa&Pdgfb; BRAF; FGF11
Chronic myeloid leukemia
BCR; NRAS; SOS1; CTBP2; TGFBR1; BRAF; SHC4; NFKBIA; SHC3; PIK3R3
Acute myeloid leukemia
PIK3R1; RAF1; NFKB1; PIK3R3; STAT3; MAP2K2; MYC; PIK3R5; ZBTB16; PIM1
Small cell lung cancer
CKS2; TRAF3; NFKBIA; PIK3R2; APAF1; NFKB1; TRAF6; SKP2; PIK3CA; TRAF5
Non-small cell lung cancer
ERBB2; PIK3CB; PIK3CD; ARAF; HRAS; PRKCB; PIK3R1; BRAF; SOS1; CCND1
Central carbon metabolism in cancer
PKM2; MAPK3; MAP2K1; PDHA2; PDK1; NRAS; SLC2A2; C12orf5; PGAM1; FGFR3
Choline metabolism in cancer
PIK3CG; SLC44A1; NRAS; RALGDS; PCYT1A; DGKD; PPAP2C; MAPK3; Pdgfa&Pdgfb; RAC1

Protein Function

PIK3R1 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity, ErbB-3 class receptor binding, insulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R1 itself. We selected most functions PIK3R1 had, and list some proteins which have the same functions with PIK3R1. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein CCKBR; PIK3R3A; PIK3R6; PIK3R1; PIK3R2; PIK3R3; PIK3R5; PIK3R3B
Function ErbB-3 class receptor binding
Related Protein NRG1; PIK3R1; CDK5; ERBB2
Function insulin binding
Related Protein HSPD1; PIK3R1; IGF1R; IDE; C2CD2L; INSR
Function insulin receptor binding
Related Protein FRS2B; SNX1; IGF2; IGF1; IRS1; DOK2; DOK3; LMBRD1; GRB10; PDPK1
Function insulin receptor substrate binding
Related Protein PIK3CA; INSR; INSRA; INSRR; PTPN11; PIK3CB; PRKCD; PIK3R1; INSRB; JAK2
Function insulin-like growth factor receptor binding
Related Protein IGF2A; INS; IGF1; ARRB1; REN; YWHAG; SOCS2; Ren1; PIK3R1; INSR
Function neurotrophin TRKA receptor binding
Related Protein GRB2; PLCG1; SHC1; PIK3R1; FRS2; EFNA5; NGFR
Function phosphatidylinositol 3-kinase binding
Related Protein FLT3; IGF1RB; IRS2; CALM3; IGF1RA; IRS4; FYN; IGF1R; CALM1; BECN1
Function phosphatidylinositol 3-kinase regulator activity
Related Protein PIK3R3A; AGAP2; KLF4; PIK3R3B; PIK3R1
Function phosphatidylinositol 3-kinase regulatory subunit binding
Related Protein FAM83A; PIK3AP1; DNM2; PTPN13; XBP1; FAM83B; PIK3R1
Function protein binding
Related Protein TRIM9; MED7; ZMYND10; CTNNA3; ZNF695; SCARB2; ORC3L; C9orf9; RAB8B; HSPB6
Function protein heterodimerization activity
Related Protein BCL2L10; HIST1H2B7; CLCF1; HIST1H4L; TAF9B; HIST1H2BN; HIST1H2B5; HAND1; MEIS1; BCL11A
Function protein phosphatase binding
Related Protein Itga10&Itgb1; HSP90B1; FLT4; TRAF3; JAK1; TRP53; VCP; STAT6; CDC27; PIK3R2
Function transcription factor binding
Related Protein HYAL1; DIP2B; DNAJA3; KAT8; SMAD2; DIP2C; SLC26A5; FOS; KCNA3; TCF12
Function transmembrane receptor protein tyrosine kinase adaptor activity
Related Protein SH2B2; STAP1; FRS2; PIK3R1; BLNK; IRS1; DOK2; GAB2; TRAT1; SHC1

Interacting Protein

PIK3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R1.
PDGFRB; CBL

PIK3R1 Related Articles

Deau, MC; Heurtier, L; et al. A human immunodeficiency caused by mutations in the PIK3R1 gene. JOURNAL OF CLINICAL INVESTIGATION 124:3923-3928(2014).
Sood, A; McClain, D; et al. PTEN Gene Expression and Mutations in the PIK3CA Gene as Predictors of Clinical Benefit to Anti-Epidermal Growth Factor Receptor Antibody Therapy in Patients With KRAS Wild-Type Metastatic Colorectal Cancer. CLINICAL COLORECTAL CANCER 11:143-150(2012).