pik3r1
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • Background
  • Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The;enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the;85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin,;and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in;four transcript variants encoding different isoforms.
  • Synonyms
  • PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphatidylinositol 3-kinase regulatory subunit alpha; GRB1; p85; p85 ALPHA; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphati
Cat.#:PIK3R1-4934HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3R1 Protein, His-tagged
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Cat.#:PIK3CA/PIK3R1-389HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1, His-tagged, Active
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Cat.#:PIK3CA/PIK3R1-631HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1, FLAG-tagged
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Cat.#:PIK3CA/PIK3R1-641HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PIK3CA/PIK3R1
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Cat.#:PIK3CB/PIK3R1-391HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CB/PIK3R1, His-tagged, Active
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Cat.#:PIK3CB/PIK3R1-632HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CB/PIK3R1, FLAG-tagged
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Cat.#:Pik3ca/PIK3R1-390HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Mouse, Human
Product nameRecombinant Mouse and Human Pik3ca/PIK3R1, His-tagged, Active
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Cat.#:PIK3R1&Pik3ca-155HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CA and Mouse Pik3ca protein, His-tagged, Active
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Cat.#:PIK3R1&PIK3CD-157HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3R1/PIK3CD protein, His-tagged, Active
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Cat.#:PIK3R1-1079HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3R1, His-tagged
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Cat.#:PIK3R1-29588THTag:His
Source (Host):Species:Human
Product nameRecombinant Human PIK3R1, His-tagged
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Cat.#:PIK3R1-29688THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CA, His-tagged
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Cat.#:PIK3R1-31096THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CB, His-tagged
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Cat.#:PIK3R1-315HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R1 protein, His/MBP-tagged
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Cat.#:PIK3R1-316HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2 protein, His/MBP-tagged
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Cat.#:PIK3R1-31767THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CB, His-tagged
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Cat.#:PIK3R1-4864HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha), His-tagged
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Cat.#:PIK3R1-4463RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIK3R1 Protein
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Cat.#:PIK3R1-3434RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R1 Protein, His-tagged
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Cat.#:PIK3R1-8346ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3R1
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Cat.#:PIK3R1-05BTag:N/A
Source (Host):Leishmania tarentolaeSpecies:Bovine
Product nameRecombinant Bovine PIK3R1
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Cat.#:PIK3R1-06BTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine PIK3R1
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Cat.#:PIK3R1-3185HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PIK3R1 293 Cell Lysate
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Involved Pathway

PIK3R1 involved in several pathways and played different roles in them. We selected most pathways PIK3R1 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
TGFA; MAPK8B; CBLB; MAP2K4B; SHC4; AKT1; HRAS; CDKN1BB; CAMK2G1; SHC3
Ras signaling pathway
PIK3R1; MRAS; PLA2G12B; ANGPT2; MAPK9; LOC608458; INS2; PLA2G4A; BAD; CALML5
Rap signaling pathway
PIK3CA; RAP1A; NRAS; ITGB2L; TLN1; CALML5; FGF7; PDGFC; BCAR1; PRKCI
cGMP-PKG signaling pathway
INSR; ATP2A2; ATP2B4; PRKG1; PPP1CB; SLC8A2; ATP2A1; NFATC2; IRS1; GNA11
cAMP signaling pathway
GRIA3; NPR1; GRIA1; OXTR; GRIN2C; GPR81; PRKACB; LOC100328615; NFKBIA; PDE4A
Chemokine signaling pathway
XCL2; IKBKG; AKT2; CXCL8; CCL7; CCL4L2; CXCL12; CCL22; PTK2B; CXCL1
HIF- signaling pathway
PGK1; GAPDH; IL6; PRKCA; PLCG2; PLCG1; TCEB1; INS1; NOX1; NOX3
FoxO signaling pathway
IGF1; SOS1; GABARAPA; CDKN1BB; CDKN1BA; PIK3CD; PIK3R2; INS; NRAS; BCL6
Phosphatidylinositol signaling system
CDS1; IP6K1; PIP5K1BB; PLCG1; PLCB3; PIP4K2B; MTMR7A; CALML3; INPP5E; IMPA2
Sphingolipid signaling pathway
DEGS1; PDPK1; PTEN; PLCB2; DEGS2; LASS2; GNAI2; TRADD; MAPK11; SGMS1
Phospholipase D signaling pathway
PRKCA; CYTH1; LPAR4; RRAS; CYTH3; GAB1; SYK; TSC1; MS4A2; FCER1G
mTOR signaling pathway
PIK3R3; RHEB; IGF1; POLDIP3; IRS1; RRAGD; PIK3R5; PIK3CB; PRR5; MLST8
PIK-Akt signaling pathway
YWHAZ; SGK3; FN1; INS1; LAMA1; TRP53; FGF5; ITGAV; MAP2K2; FGF21
AMPK signaling pathway
PFKFB2; ADIPOR1; RAB14; CREB3L1; CREB3L2; INSR; CCND1; G6PC3; FASN; PRKAG1
Apoptosis
RNF8; IL1RAP; IKBKB; JUN; RIPK1L; BNIP3L; PPP3CB; ADD1; DSG3; RIPK1
Adrenergic signaling in cardiomyocytes
CACNG6; PPP1CAB; ADRA1BB; PLCB2; TPMA; ADRB3B; PPP2R5EB; ADCY6; CALM3; ATP2B3B
VEGF signaling pathway
PPP3R1; SPHK2; PTK2AB; PPP3CCA; PXN; RAC1; PPP3CA; RAF1; PLA2G4A; MAPK14A
Osteoclast differentiation
GRB2; LILRA4; TNFRSF11A; PPARG; TGFBR1; ACP5; SIRP-BETA; PPP3R2; LILRB5; PPP3CC
Focal adhesion
IGF1; ROCK2B; LAMB2; GRB2B; MYLPF; COL4A2; CHAD; COL6A3; BCAR1; IGF1RA
Signaling pathways regulating pluripotency of stem cells
SMARCAD1; HRAS; WNT2; ACVR1B; HAND1; SETDB1; FGFR1; PIK3R2; NEUROG1; ACVR2A
Platelet activation
MAPK3; F2R; P2RX1; PTGS1; RAP1B; ARHGEF12; PTGIR; GP5; NOS3; COL24A1
Toll-like receptor signaling pathway
CCL4L1; MAPK14B; IKBKG; TLR1LA; MAP2K4B; STAT1B; IFNA6; IFNPHI3; AKT2L; IRF3
Jak-STAT signaling pathway
IL23R; PIK3R1; CCND1; PIAS1; MCL1A; PRL; IL22; JAK2A; IFNA7; GM-CSF
Natural killer cell mediated cytotoxicity
HLA-A; PLCG2; KLRC4-KLRK1; FCER1G; IFNA5; IFNA4; SH3BP2; Casp3; PPP3R2; Fasl
T cell receptor signaling pathway
ICOS; CBLB; VAV3; RAF1; HRAS; IL4; NCK1; NFATC3; PIK3CB; LCK
B cell receptor signaling pathway
PLCG2; PILRB; BTK; KRAS; NFKBIE; RAF1; LIME1; MAPK4; PTPN18; RAP2A
Fc epsilon RI signaling pathway
GM-CSF; LYN; PLCG1; INPP5D; PLA2G4C; MAPK10; MAPK8; PLA2G4B; BTK; PLA2G4A
Fc gamma R-mediated phagocytosis
VAV2; PIP5K1B; INPP5D; PLA2G4D; ASAP3; WASF1; PIP5K1C; CFL1; SCIN; VASP
TNF signaling pathway
MMP14; PIK3CA; NFKB1; BAG4; MAPK13; MAP2K4; MMP9; Ccl12; MAP3K14; CREB5
Leukocyte transendothelial migration
VAV1; NIPAL1; VCAM1; MYL7; ACTN3; ITGB2; MAPK12; THY1; CLDN6; PXN
Neurotrophin signaling pathway
KRAS; MAP2K5; SHC1; NTF3; CAMK2A; IRS1; RPS6KA2; CALM1; IRAK1; CALML3
Cholinergic synapse
KCNQ5; CREB3L3; PIK3R3; GNG2; GNG13; SLC5A7; PIK3CA; GNG3; CAMK4; GNG4
Inflammatory mediator regulation of TRP channels
PRKACG; MAPK8; PLA2G4D; PLCG2; PPP1CA; CALM3; ASIC3; PRKCD; PIK3CA; PLCB3
Regulation of actin cytoskeleton
VAV3; ACTN3A; BRK1; FGF7; MAPK6; MYLK3; DIAPH1; FGF3; MOS; PDGFB
Insulin signaling pathway
PIK3CD; TSC1; PPP1R3CB; INPPL1; PRKAR1B; AKT2L; PPP1CBL; CBLC; KRAS; PHKB
Progesterone-mediated oocyte maturation
HSP90AA1.2; PIK3R5; MAPK12B; MAPK3; CCNA1; GNAIA; MAP2K1; PRKACB; MAPK8B; IGF1R
Estrogen signaling pathway
MAPK3; HRAS; GABBR2; CREB3L3; FKBP4; PIK3CB; SHC4; SP1; PIK3CG; CALM1
Prolactin signaling pathway
SOCS6; MAPK10; INS; FOS; PIK3CD; MAPK9; PIK3CB; INS2; PIK3R2; MAPK8
Thyroid hormone signaling pathway
ATP1A2; SLC16A10; PLCB4; NCOA3; SLC9A1; FXYD2; PIK3R1; CCND1; THRB; MED1
Oxytocin signaling pathway
PRKACG; PLCB2; GNAI2; PLA2G4C; PLA2G4A; PIK3R1; PRKAB1; CACNA2D1; NFATC2; ELK1
Regulation of lipolysis in adipocytes
GNAS; FABP4; PRKACA; INS1; PIK3R3; TSHB; LIPE; PLIN1; INS2; PRKG1
Type II diabetes mellitus
MAPK8; INS2; SOCS1; MAFA; MAPK10; SOCS2; MAPK3; PIK3CA; MTOR; HKDC1
Insulin resistance
PRKAA2; RPS6KA3A; SLC27A4; PPP1CB; PRKCZ; PPARGC1A; CREB3L2; OGT; PPP1CA; MLXIPL
Non-alcoholic fatty liver disease (NAFLD)
CEBPA; NDUFA4; NDUFB5; NDUFB11; ATF4; NDUFS6; NDUFB8; NDUFA8; PIK3CA; NFKB1
Aldosterone-regulated sodium reabsorption
IRS1; PIK3R2; ATP1A2; KCNJ1; ATP1B3; ATP1A3; ATP1A1; SCNN1B; SGK1; SCNN1G
Carbohydrate digestion and absorption
AMY2A4; TAS1R3; AMY1B; HK3; PIK3CB; HKDC1; AMY2A; ATP1A2; PIK3CA; PLCB2
Bacterial invasion of epithelial cells
ELMO2; CAV1; PIK3CD; ACTG1; PXN; PIK3R2; ITGB1; ELMO3; SHC4; ARPC4
Chagas disease (American trypanosomiasis)
CD3G; MAPK11; IL1B; MAPK9; CCL2; SMAD3; PPP2CB; CCL3; GNAL; CFLAR
Toxoplasmosis
IRGM; PIK3R1; LAMB4; BIRC3; HSPA1A; LAMA2; STAT3; MAPK9; ITGA6; MAPK13
Amoebiasis
COL1A2; LAMC2; AASS; RAB5B; PIK3CG; TGFB2; SERPINB3C; GNAQ; CXCL8; ACTN3
Hepatitis C
TRAF3; TBK1; TNFRSF1A; IFNA8; EIF2AK4; PPP2R2D; IFNAR2; CLDN10; PIK3CB; OAS2
Hepatitis B
IFNA10; MAVS; IFNA6; FAS; RB1; OSTN; PRKCA; FOS; IRF7; MAP2K2
Measles
TRAF6; IL2RA; CD209; IRF7; RELA; IL1B; FCGR2B; OAS2; Cd209g; TACR1
Influenza A
EP300; BLB1; IFNA8; PABPN1L; STAT1; BLB2; HLA-DRA; PIK3CD; MX1; NLRP3
HTLV-I infection
ITGAL; PPP3R1; HLA-DQA2; TNFRSF13C; BUB1B; HLA-DRB3; TERT; SLC25A6; PPP3CC; POLE4
Epstein-Barr virus infection
ENTPD8; PSMD3; HLA-DRB3; POLR3C; NEDD4; MAP2K4; CD44; POLR2D; EIF2AK4; HLA-DRB4
Pathways in cancer
FLT3; FADD; LAMC2; GNB2; MET; MAPK10; CTBP2; TGFBR1; GNG5; BMP4
Viral carcinogenesis
PMAIP1; CCNA1; HIST1H2BJ; H2BFWT; HLA-G; HIST1H2BC; HLA-E; PRKACG; TRAF2; CREB3L2
Proteoglycans in cancer
ITPR3; WNT7A; FZD7; PRKCB; PLCG2; ARAF; CAMK2D; FLNA; FAS; NUDT16L1
Colorectal cancer
BCL2; GSK3B; PIK3CD; RAC1; LEF1; MAPK3; FOS; TGFB1; MAP2K1; DCC
Renal cell carcinoma
PAK1; PAK3; RAP1B; AKT2; PIK3R3; EGLN1; PIK3CD; MAP2K1; TGFB1; TGFB3
Pancreatic cancer
TGFB2; PIK3CG; VEGFA; MAP2K1; TGFA; PIK3CB; RB1; AKT1; MAPK1; PIK3CD
Endometrial cancer
TP53; AXIN2; HRAS; BRAF; ELK1; CASP9; GSK3B; TCF7L2; GRB2; AKT1
Glioma
CALM4; CALM1; CCND1; IGF1; AKT2; PRKCB; PDGFRB; CAMK2A; CALM3; PLCG2
Prostate cancer
MAPK3; MAP2K2; MAP4K1; EP300; HSP90AA1; PIK3R5; MDM2; ATF4; Ar; SOS1
Melanoma
MITF; MDM2; TP53; FGF11; BAD; FGF9; IGF1; FGFR1; PIK3R3; HRAS
Chronic myeloid leukemia
SHC1; RB1; SHC2; TGFB3; HRAS; TGFB2; PIK3CG; CTBP1; RAF1; TGFBR2
Acute myeloid leukemia
PPARD; AKT3; MTOR; TCF7L2; PIK3CG; KIT; SPI1; BAD; GRB2; ZBTB16
Small cell lung cancer
ITGA2B; LAMA1; PIK3R1; CKS2; PIK3R3; FN1; PIK3R5; BIRC2; TRAF1; LAMA3
Non-small cell lung cancer
PDPK1; PLCG1; BAD; FHIT; PRKCA; SOS1; RASSF5; RASSF1; RAF1; ERBB2
Central carbon metabolism in cancer
NTRK1; PFKL; PIK3CA; HK3; PKM2; SLC1A5; SCO2; NRAS; NTRK3; TRP53
Choline metabolism in cancer
CHKB; PIK3CG; RPS6KB2; MTOR; HRAS; SLC22A2; RPS6KB1; RHEB; PRKCA; PIK3CB

Protein Function

PIK3R1 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity, ErbB-3 class receptor binding, insulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R1 itself. We selected most functions PIK3R1 had, and list some proteins which have the same functions with PIK3R1. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein PIK3R3B; PIK3R6; PIK3R5; PIK3R3A; PIK3R2; CCKBR; PIK3R3; PIK3R1
Function ErbB-3 class receptor binding
Related Protein CDK5; ERBB2; PIK3R1; NRG1
Function insulin binding
Related Protein C2CD2L; IDE; INSR; HSPD1; PIK3R1; IGF1R
Function insulin receptor binding
Related Protein ENPP1; IGF2; PDPK1; SLC2A2; PHIP; INS; DOK3; PTPN1; DOK2; FRS2A
Function insulin receptor substrate binding
Related Protein PRKCD; PIK3CB; PRKCZ; INSRA; PTPN11; IGF1R; INSRR; IGF1RB; JAK2; PIK3CA
Function insulin-like growth factor receptor binding
Related Protein ARRB1; SOCS1; IGF2; YWHAG; SOCS2; IGF2A; YWHAH; IGF1; Ren1; PIK3R1
Function neurotrophin TRKA receptor binding
Related Protein EFNA5; FRS2; PIK3R1; PLCG1; SHC1; NGFR; GRB2
Function phosphatidylinositol 3-kinase binding
Related Protein IGF1R; IRS4; ATP1A1; BECN1; DAB1; INSRA; INSR; IRS1; PIK3R1; FLT3
Function phosphatidylinositol 3-kinase regulator activity
Related Protein KLF4; PIK3R1; PIK3R3A; AGAP2; PIK3R3B
Function phosphatidylinositol 3-kinase regulatory subunit binding
Related Protein PIK3R1; PIK3AP1; FAM83B; PTPN13; FAM83A; XBP1; DNM2
Function protein binding
Related Protein C12orf49; SERPINE2; BBOX1; MAGEA8; FAF2; SUMO3; TUB; LSM11; FBN2; RAB25
Function protein heterodimerization activity
Related Protein HNF1B; ADRA2A; GUCY1A3; SYCP3; MAFGB; SMAD3; HIST1H4B; PIK3R2; TAL1; SYT14
Function protein phosphatase binding
Related Protein ERBB2; MVP; GRB2; MAP2K7; HSP90B1; MET; VRK3; JAK3; SNX3; PPARG
Function transcription factor binding
Related Protein PDX1; HDAC4; RORA; MYC; PITX2; NFYC; PPP1R13L; DDX3X; VDRA; MDFIC
Function transmembrane receptor protein tyrosine kinase adaptor activity
Related Protein IRS1; PIK3R1; SH2B2; STAP1; SHC1; GAB2; BLNK; FRS2; TRAT1; DOK2

Interacting Protein

PIK3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R1.
PDGFRB; CBL

PIK3R1 Related Articles

Deau, MC; Heurtier, L; et al. A human immunodeficiency caused by mutations in the PIK3R1 gene. JOURNAL OF CLINICAL INVESTIGATION 124:3923-3928(2014).
Sood, A; McClain, D; et al. PTEN Gene Expression and Mutations in the PIK3CA Gene as Predictors of Clinical Benefit to Anti-Epidermal Growth Factor Receptor Antibody Therapy in Patients With KRAS Wild-Type Metastatic Colorectal Cancer. CLINICAL COLORECTAL CANCER 11:143-150(2012).