PNPLA3
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Official Full Name
patatin-like phospholipase domain containing 3
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Overview
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. -
Synonyms
PNPLA3; patatin-like phospholipase domain containing 3; adiponutrin , ADPN, C22orf20, chromosome 22 open reading frame 20; patatin-like phospholipase domain-containing protein 3; adiponutrin; dJ796I17.1; FLJ22012; Acylglycerol O acyltransferase; ADPN; C22orf20; Calcium independent phospholipase A2 epsilon; iPLA(2)epsilon; Patatin like phospholipase domain containing 3; iPLA2-epsilon; OTTHUMP00000197822; OTTHUMP00000197823; acylglycerol O-acyltransferase; calcium-independent phospholipase A2-epsilon;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Wheat germ cell free in vitro
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PNPLA3 Related Articles
- PNPLA3 Related Research Area
PNPLA3 involved in several pathways and played different roles in them. We selected most pathways PNPLA3 participated on our site, such as Glycerolipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPLA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerolipid metabolism | GLYCTK;CEL.1;DGKA;LCLAT1;PPAP2B;AGPAT3;GPAM;CELL;LPL |
| Metabolic pathways | ATP5C1;ADSSL;SPTLC1;PCXB;NDUFA10;PNP6;CBR1;MTHFD1B;MCEE |
PNPLA3 has several biochemical functions, for example, diolein transacylation activity, mono-olein transacylation activity, phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPLA3 itself. We selected most functions PNPLA3 had, and list some proteins which have the same functions with PNPLA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| diolein transacylation activity | |
| mono-olein transacylation activity | |
| phospholipase A2 activity | OC90;PLB1;PLA2G6;PLA2G2A;PLA2G1B;PLA2G16;PLA2G2F;PRDX6;PLA2G4A |
| triglyceride lipase activity | PNLIP;CEL.1;PNLIPRP3;LIPC;LPL;PNLIPRP1;CES5A;PNPLA2;PNPLA4 |
PNPLA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPLA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPLA3.
AKT2; SNX27
- Q&As
- Reviews
Q&As (5)
Ask a questionPNPLA3 primarily influences lipid metabolism and liver health, but there may be connections with other metabolic disorders.
Yes, dietary and lifestyle modifications, such as weight loss and reduced alcohol consumption, can help manage liver diseases associated with PNPLA3 variants.
PNPLA3 variants may accelerate liver fibrosis in NAFLD, making it a potential marker for disease severity.
Yes, PNPLA3 gene variants can be inherited from parents and can increase the risk of liver diseases in children.
There are no specific drugs targeting PNPLA3, but therapies for liver diseases often take into account a patient's genetic profile, including PNPLA3 variants.
Customer Reviews (3)
Write a reviewManufacturers should ensure the consistency and quality of PNPLA3 protein products.
The PNPLA3 protein offered by the manufacturer exhibits exceptional quality and is precisely tailored to meet my experimental requirements.
Its purity, stability, and functionality make it an ideal choice for my research endeavors.
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