PNPLA3 Protein, patatin-like phospholipase domain containing 3


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Official Full Name patatin-like phospholipase domain containing 3
Background The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.
Synonyms PNPLA3; patatin-like phospholipase domain containing 3; adiponutrin , ADPN, C22orf20, chromosome 22 open reading frame 20; patatin-like phospholipase domain-containing protein 3; adiponutrin; dJ796I17.1; FLJ22012; Acylglycerol O acyltransferase; ADPN; C22orf20; Calcium independent phospholipase A2 epsilon; iPLA(2)epsilon; Patatin like phospholipase domain containing 3; iPLA2-epsilon; OTTHUMP00000197822; OTTHUMP00000197823; acylglycerol O-acyltransferase; calcium-independent phospholipase A2-epsilon
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PNPLA3-1819H Recombinant Human PNPLA3 protein, GST-tagged E.coli GST
    Human PNPLA3-1820H Recombinant Human PNPLA3 protein, His-tagged E.coli His
    Human PNPLA3-091H Recombinant Human PNPLA3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Mouse Pnpla3-588M Recombinant Mouse Pnpla3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human PNPLA3-1818H Recombinant Human PNPLA3, GST-tagged E.coli GST
    Human PNPLA3-26H Recombinant Human PNPLA3 Protein, GST-tagged Wheat Germ GST
    Human PNPLA3-3068HCL Recombinant Human PNPLA3 293 Cell Lysate HEK293 N/A
    Human PNPLA3-321H Recombinant Human PNPLA3, His-tagged E.coli His
    Human PNPLA3-367H Recombinant Human PNPLA3 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Zebrafish PNPLA3-487Z Recombinant Zebrafish PNPLA3 Mammalian Cell His

    PNPLA3 involved in several pathways and played different roles in them. We selected most pathways PNPLA3 participated on our site, such as Glycerolipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPLA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerolipid metabolism ALDH3A2A; DGKE; MOGAT1; AKR1B8; AGPAT6; GPAM; LPIN1; LPIN2; AGPAT9; ALDH2.2
    Metabolic pathways PPAP2C; ALDH6A1; GK2; AKR1B10; MIBP2; DLAT; GBA2; MVK; UGT1AB; ACSBG2

    PNPLA3 has several biochemical functions, for example, diolein transacylation activity, mono-olein transacylation activity, phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPLA3 itself. We selected most functions PNPLA3 had, and list some proteins which have the same functions with PNPLA3. You can find most of the proteins on our site.

    Function Related Protein
    diolein transacylation activity PNPLA3
    mono-olein transacylation activity PNPLA3
    phospholipase A2 activity OC90; PNPLA3; PLA2G12B; PLA2G10; LCAT; PLA2G2E; PLA2G4D; PLA2G4A; RARRES3; PLA2G4AA
    triglyceride lipase activity LIPC; LPL; CES3; Cel; PNPLA2; CES1; CES5A; CEL.1; CES1D; PNPLA3

    PNPLA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPLA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPLA3.

    AKT2; SNX27

    Huang, CF; Dai, CY; et al. Association of diabetes and PNPLA3 genetic variants with disease severity of patients with chronic hepatitis C virus infection. JOURNAL OF HEPATOLOGY 62:512-518(2015).
    Zhou, Y; Llaurado, G; et al. Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2. JOURNAL OF HEPATOLOGY 62:657-663(2015).

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