polg
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  • Official Full Name
  • polymerase (DNA directed), gamma
  • Background
  • exhibits DNA polymerase activity; may mediate the final step of mitochondrial DNA repair
  • Synonyms
  • POLG; polymerase (DNA directed), gamma; DNA polymerase subunit gamma-1; POLG1; POLGA; PolG-alpha; PolG, catalytic subunit; mitochondrial DNA polymerase catalytic subunit; PEO; MDP1; SCAE; MIRAS; SANDO; MTDPS4A; MTDPS4B; FLJ27114
Cat.#:POLG-317HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLG Protein, His-tagged
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Cat.#:POLG-1525HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human POLG protein
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Cat.#:POLG-1832HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLG, GST-tagged
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Cat.#:POLG-28364THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human POLG
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Cat.#:POLG-632HTag:
Source (Host):Species:Human
Product nameRecombinant Human POLG protein
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Cat.#:POLG-4565RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat POLG Protein
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Involved Pathway

POLG involved in several pathways and played different roles in them. We selected most pathways POLG participated on our site, such as Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLG were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolic pathways
LDHC; ODC1; MAPK1IP1L; NANSA; GALK1; ALDH2.1; PIK3C2B; OGDH; COX15; XDH

Protein Function

POLG has several biochemical functions, for example, 3-5 exonuclease activity, DNA binding, DNA-directed DNA polymerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLG itself. We selected most functions POLG had, and list some proteins which have the same functions with POLG. You can find most of the proteins on our site.
Function
Related Protein
Function 3-5 exonuclease activity
Related Protein EXD1; EXOSC10; REV3L; RAD9A; POLG; RAD9; RAD9B; EXD2; POLA1; RAD1
Function DNA binding
Related Protein RFX1A; TSG101; ZIM3; DBX1B; TOP2A; HESX1; PROX1A; LHX1A; ZNF383; HIST1H2AC
Function DNA-directed DNA polymerase activity
Related Protein POLG2; POLD4; POLD3; MYBBP1A; POLL; POLA2; POLI; POLE4; POLE3; POLK
Function chromatin binding
Related Protein YBX2; LHX2; HOXD10; HMGB2; MECP2; ANKRD17; MEIOB; MBD5; SIN3A; KLF6A
Function protease binding
Related Protein RFFL; UBC; SEMG2; ECM1; INS2; ADAM8A; TIMP1; CAST; THAP5; A2M
Function protein binding
Related Protein MT1X; RAB35; PRC1; POLL; TNK2; KLHDC5; PIGS; SETD7; MTF1; AP5Z1

Interacting Protein

POLG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLG here. Most of them are supplied by our site. Hope this information will be useful for your research of POLG.
POLG2; Dlg4; q2i360_hbv; ssdna_dn

POLG Related Articles

Arkadir, D; Meiner, V; et al. Teaching NeuroImages: Hypertrophic olivary degeneration in a young man with POLG gene mutation. NEUROLOGY 84:e59-e59(2015).
Golob, MJ; Tian, L; et al. Mitochondria DNA mutations cause sex-dependent development of hypertension and alterations in cardiovascular function. JOURNAL OF BIOMECHANICS 48:405-412(2015).