Recombinant Human POLG protein

• Cat.No.: POLG-632H

Specification

• Description: Human DNA Polymerase Gamma is a mitochondrial enzyme used for testing the toxicity of drugs on critical human oxidative functions. Mitochondrial enzyme used for testing the toxicity of drugs on critical human oxidative functions and testing replication of mitochondrial DNA.
• Species: Human
• Form: 20 mM Tris-HCl (pH 8.0), 50 mM NaCl. 50 µg/ml PMSF, 0.05% Triton X-100™, 10% DMSO, 5% glycerol
• Unit Definition: One unit is the amount of enzyme required to incorporate 1 pmole of total nucleotide into acid-insoluble form in 60 minutes at 37 centigrade.
• Notes: All preparations are assayed for contaminating endonuclease and exonuclease activities.
• Storage: Store at -80 centigrade Long Term, -20 centigrade Short Term.Avoid multiple freeze / thaw cycles.

Gene Information

• Gene Name: POLG polymerase (DNA directed), gamma [ Homo sapiens ]
• Official Symbol: POLG
• Synonyms: POLG; polymerase (DNA directed), gamma; DNA polymerase subunit gamma-1; POLG1; POLGA; PolG-alpha; PolG, catalytic subunit; mitochondrial DNA polymerase catalytic subunit; PEO; MDP1; SCAE; MIRAS; SANDO; MTDPS4A; MTDPS4B; FLJ27114
• Gene ID: 5428
• mRNA Refseq: NM_001126131
• Protein Refseq: NP_001119603
• MIM: 174763
• UniProt ID: P54098
• Chromosome Location: 15q24
• Pathway: DNA polymerase gamma complex, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Nucleotide Metabolism, organism-specific biosystem
• Function: DNA binding; DNA-directed DNA polymerase activity; chromatin binding; exonuclease activity; nucleotidyltransferase activity; protease binding; protein binding; transferase activity