prdx1
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  • Official Full Name
  • peroxiredoxin 1
  • Background
  • Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1- Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxindependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 – 30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
  • Synonyms
  • PRDX1; peroxiredoxin 1; PAGA; peroxiredoxin-1; NKEFA; NKEF-A; thioredoxin peroxidase 2; proliferation-associated gene A; natural killer-enhancing factor A; proliferation-associated gene protein; natural killer cell-enhancing factor A; thioredoxin-dependen
Cat.#:PRDX1-2033CTag:His
Source (Host):E. coliSpecies:Cricetulus Griseus
Product nameRecombinant Cricetulus Griseus PRDX1 Protein (2-199 aa), His-tagged
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Cat.#:PRDX1-2430HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human PRDX1 Protein (1-199 aa), His-tagged
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Cat.#:PRDX1-2679CTag:His
Source (Host):YeastSpecies:Cricetulus Griseus
Product nameRecombinant Cricetulus Griseus PRDX1 Protein (2-199 aa), His-tagged
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Cat.#:PRDX1-504HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRDX1 Protein (Met1-Lys199), His-tagged
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Cat.#:PRDX1-134HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Peroxiredoxin 1, His-tagged
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Cat.#:PRDX1-1939HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRDX1, GST-tagged
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Cat.#:PRDX1-423HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Peroxiredoxin 1, His-tagged
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Cat.#:Prdx1-2544MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prdx1, His tagged
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Cat.#:Prdx1-60MTag:His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Prdx1 Protein, His-tagged
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Cat.#:Prdx1-8047MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prdx1 protein, His & GST-tagged
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Cat.#:PRDX1-4658RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRDX1 Protein
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Cat.#:PRDX1-3589RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRDX1 Protein, His-tagged
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Cat.#:PRDX1-4683CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRDX1
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Cat.#:PRDX1-2153ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PRDX1
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Cat.#:PRDX1-2882HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRDX1 293 Cell Lysate
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Cat.#:PRDX1-2883HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRDX1 293 Cell Lysate
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Involved Pathway

PRDX1 involved in several pathways and played different roles in them. We selected most pathways PRDX1 participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Peroxisome
SCP2A; PIPOX; NOS2B; MPV17L2; FAR2; PMVK; SOD1; ACSL4B; DAO.1; PXMP4

Protein Function

PRDX1 has several biochemical functions, for example, identical protein binding, peroxidase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDX1 itself. We selected most functions PRDX1 had, and list some proteins which have the same functions with PRDX1. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein G6PD; CHMP4B; ROBO1; STAC3; ALAD; RGMB; ABCD1; CLDN4; FGFR1; COIL
Function peroxidase activity
Related Protein PTGS2A; DUOX2; PTGS2; PTGS1; GPX6; PRDX5; MPO; IPCEF1; MGST3; PTGS2B
Function poly(A) RNA binding
Related Protein MKI67; MFAP1B; ZFP36L1; RBM47; NSA2; PRPF40A; POLR2A; RSRC2; HIST1H4D; ZCCHC3
Function protein binding
Related Protein RBFOX2; TSGA10IP; KRTAP10-9; SMARCAD1; PPP3CA; UQCC2; RRAS; CCL20; IQSEC3; BLOC1S1
Function thioredoxin peroxidase activity
Related Protein PRDX4; PRDX3; PRDX1; PRDX2

Interacting Protein

PRDX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDX1.
STK4; PTEN; AR