prg2
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  • Official Full Name
  • proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
  • Background
  • The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • PRG2; proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein); MBP; BMPG; MBP1; bone marrow proteoglycan; bone-marrow proteoglycan; proteoglycan 2 preproprotein; natural killer cell activator; eosinophil major basic protein; eosinophil granule major basic protein; prg-2; Piwi (fruitfly) Related Gene; Piwi (fruitfly) Related Gene family member (prg-2); 4H292; tag-292
Cat.#:PRG2-1749HTag:His-GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRG2 Protein, His-GST-tagged
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Cat.#:PRG2-1745HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRG2 protein, His & MBP-tagged
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Cat.#:PRG2-44HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRG2, His-tagged
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Cat.#:PRG2-45HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PRG2, GST-tagged
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Cat.#:PRG2-46HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRG2, StrepII-tagged
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Cat.#:Prg2-1746MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prg2 protein, His & GST-tagged
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Cat.#:Prg2-1747RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Prg2 protein, His & GST-tagged
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Cat.#:PRG2-2872HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRG2 293 Cell Lysate
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Involved Pathway

PRG2 involved in several pathways and played different roles in them. We selected most pathways PRG2 participated on our site, such as Asthma, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Asthma
IL9; HLA-DQB1; HLA-DOA; HLA-DOB; HLA-DQA2; IL13; IL5; HLA-DRB3; PRG2; HLA-DRB5

Protein Function

PRG2 has several biochemical functions, for example, carbohydrate binding, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRG2 itself. We selected most functions PRG2 had, and list some proteins which have the same functions with PRG2. You can find most of the proteins on our site.
Function
Related Protein
Function carbohydrate binding
Related Protein ILLR3; CLEC6A; LMAN1L; LGALS8; SORD; Siglec1; CHI3L1; GANAB; KLRC1; GALNT4
Function heparin binding
Related Protein PCOLCE2; SOST; APP; CXCL10; NRP1; CYR61; ADAMTS1; FBLN7; CHRD; FGF12

Interacting Protein

PRG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRG2.
CHD3; RBM48