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PRKAA1

  • Official Full Name

    protein kinase, AMP-activated, alpha 1 catalytic subunit

  • Overview

    The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms

    PRKAA1; protein kinase, AMP-activated, alpha 1 catalytic subunit; 5-AMP-activated protein kinase catalytic subunit alpha-1; AMPK; alpha; 1; AMPKa1; AMPK alpha 1; AMPK subunit alpha-1; tau-protein kinase PRKAA1; AMP -activate kinase alpha 1 subunit; AMP-ac;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • DDK
  • Flag
  • GST
  • His
  • GST|His
  • His (Fc)
  • Avi
  • His|MBP
  • His|T7
  • Myc
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRKAA1-76H Active Recombinant Human AMPK (A1/B2/G2), GST-His-tagged Sf9 Insect Cell GST/His
Human PRKAA1-77H Active Recombinant Human AMPK (A1/B2/G3), GST-His-tagged Sf9 Insect Cell GST/His
Human AMPK(A1/B2/G1)-244H Recombinant Human AMPK (A1/B2/G1), His-tagged, Active Sf9 Insect Cell His
Human PRKAA1-740H Recombinant Human PRKAA1, GST-His Sf9 Insect Cell GST
Human PRKAA1-41H Recombinant Human AMPK (combination of A1/B1/G3 subunits), GST-His-tagged Sf9 Insect Cell GST/His
Human PRKAA1-40H Recombinant Human AMPK (combination of A1/B1/G2 subunits), GST-His-tagged Sf9 Insect Cell GST/His
Human PRKAA1-372H Recombinant Human PRKAA1 protein, His/MBP-tagged E.coli His/MBP 264-406 aa
Human PRKAA1-1944H Recombinant Human PRKAA1, GST-tagged E.coli GST N-term-207aa
Human PRKAA1-612H Recombinant Human PRKAA1 Mammalian Cell His
Human PRKAA1-775H Recombinant Human PRKAA1 protein, His & T7-tagged E.coli His/T7 Gly198~Lys448 (Accession # Q13131)
Human PRKAA1-371H Recombinant Human PRKAA1 protein, His/MBP-tagged E.coli His/MBP 411-543 aa
Human PRKAA1-42H Recombinant Human AMPK (combination of A1/B2/G1 subunits), GST-His-tagged Sf9 Insect Cell GST/His
Human PRKAA1-373H Recombinant Human PRKAA1 protein, His/MBP-tagged E.coli His/MBP 1-78 aa
Human PRKAA1-1412HCL Recombinant Human PRKAA1 cell lysate N/A
Human PRKAA1-2412HF Active Recombinant Full Length Human PRKAA1 Protein, GST-tagged Insect (sf21) GST 1-550(end)
Human PRKAA1-007H Active Recombinant Human PRKAA1 Protein, His-tagged Insect cell His α1: 1-559; β1: 1-270; γ1: 1-331
Human PRKAA1-2953H Recombinant Human PRKAA1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PRKAA1-147H Recombinant Human PRKAA1 Protein, His-tagged E.coli N-His Gly198-Lys448
Human PRKAA1-9836HF Active Recombinant Full Length Human PRKAA1 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-550(end)
Human PRKAA1-1007HFL Recombinant Full Length Human PRKAA1 Protein, C-Flag-tagged Mammalian cells Flag
Human PRKAA1-4741H Recombinant Human PRKAA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PRKAA1-5981H Recombinant Human PRKAA1 Protein (Met10-Gln559), N-His tagged E.coli N-His Met10-Gln559
Human PRKAA1-8419HF Active Recombinant Full Length Human PRKAA1 Protein, GST-tagged Insect (sf21) GST 1-550(end)
Human PRKAA1-3871H Recombinant Human PRKAA1 protein, His-tagged E.coli His 1-207 aa
Human PRKAA1-6297HF Active Recombinant Full Length Human PRKAA1 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-550(end)
Human PRKAA1-06H Recombinant Human PRKAA1 complex Protein, N-Flag-tagged Insect Cell N-Flag
Human PRKAA1-1762H Recombinant Human PRKAA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PRKAA1-01H Recombinant Human PRKAA1 Protein (K45R) E.coli
Human PRKAA1-1762H-B Recombinant Human PRKAA1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Prkaa1-285M Recombinant Mouse Prkaa1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Prkaa1-4504M Recombinant Mouse Prkaa1 protein, His-tagged E.coli His 1-312aa
Mouse Prkaa1-2311M Recombinant Mouse Prkaa1 protein, GST&His-tagged Insect Cell GST/His 1-559aa
Mouse Prkaa1-2312M Recombinant Mouse Prkaa1 protein, His-tagged Insect Cell His 1-559aa
Rat Prkaa1-144R Active Recombinant Rat Prkaa1(T172D), GST/MYC-tagged E.coli N/A
Rat PRKAA1-4668R Recombinant Rat PRKAA1 Protein Mammalian Cell His
Rat PRKAA1-4327R Recombinant Rat PRKAA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PRKAA1-4327R-B Recombinant Rat PRKAA1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PRKAA1-6131Z Recombinant Zebrafish PRKAA1 Mammalian Cell His
Chicken PRKAA1-3399C Recombinant Chicken PRKAA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRKAA1 Related Research Area

PRKAA1 involved in several pathways and played different roles in them. We selected most pathways PRKAA1 participated on our site, such as FoxO signaling pathway, Regulation of autophagy, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayPRKAG3B;FOXO6;HRAS;KLF2B;G6PC3;MAPK11;CDKN1BA;MAP2K1;IKBKB
Regulation of autophagyIFNA3;IFNA14;IFNA1;IFNA21;IFNA7;IFNPHI1;Ifna11;IFNA13;ATG14
mTOR signaling pathwayRPS6KB2;PTENA;STK11;VEGFA;RPS6;MLST8;INS2;EIF4E1B;PRKCBA
PIK-Akt signaling pathwayMCL1;INS1;PIK3R3;TNR;KLK1B4;LAMA5;FGF22;CCNE2;GNG3
AMPK signaling pathwaySCD5;CCNA2;PPP2R5D;CCND1;Scd1;PPARG;IGF1R;PPP2R3C;PPP2R5E
Circadian rhythmBTRC;PRKAG2;PRKAG1;FBXL3;RBX1;CLOCK;PRKAA1;PRKAG3;NR1D1
Insulin signaling pathwayPPP1R3CA;IRS4;SHC2;SREBF1;PIK3R5;INSB;PRKACAB;CBLB;PDE3B
Adipocytokine signaling pathwayPTPN11A;ADIPOR1;PRKAA2;PRKAG2;MAPK9;PRKAB1A;ACSBG1;JAK2A;STAT3
Oxytocin signaling pathwayMAP2K2;ROCK1;PRKAB2;Adcy4;CALML3;RCAN1;PRKAG3;TRPM2;SRC
Insulin resistanceGFPT1;AKT3A;GFPT2;CRTC2;G6PCA.2;SOCS3B;PPARGC1B;INSRB;PRKAG1
Non-alcoholic fatty liver disease (NAFLD)COX7A1;UQCRC1;PRKAB2;EIF2AK3;NDUFB9;RXRA;MAPK8;NDUFS3;UQCRFS1
Hypertrophic cardiomyopathy (HCM)PRKAG3;EMD;TTN;CACNA2D3;MYL2;ACTB;TPM2;TGFB3;CACNB2

PRKAA1 has several biochemical functions, for example, AMP-activated protein kinase activity, ATP binding, [acetyl-CoA carboxylase] kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAA1 itself. We selected most functions PRKAA1 had, and list some proteins which have the same functions with PRKAA1. You can find most of the proteins on our site.

Function Related Protein
AMP-activated protein kinase activityPRKAA1;PRKAG3;ALPK2;PRKAG2;PRKAB1;PRKAA2
ATP bindingACTA2;DAPK3;MCM3L;PTK7A;CHORDC1;ATP9A;KITB;ADRBK2;MCM6L
[acetyl-CoA carboxylase] kinase activityPRKAA1;PRKAA2
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activityPRKAA1;PRKAA2
cAMP-dependent protein kinase activityPRKACB;PRKAG1;PRKAA1;PRKX;AKAP13;PRKACA;PRKACG
chromatin bindingCREB3;MECP2;ZGLP1;TTC5;EYA3;HDGFRP2;LDB1;YAP1;MORF4L1
histone serine kinase activityPRKAA2;AURKC;ATM;AURKA;AURKB;PRKAA1
kinase bindingCAB39;PER3;MOBKL1A;SNAI1;MOB4;TENC1;STRADA;PRKCD;PPP2R5A
metal ion bindingZNF225;ATP2B2;DRL;ACACB;NR2F6B;DZIP1L;RNF144AB;IKZF5;CYP2AA4
protein C-terminus bindingSNF8;NPAT;PEX1;MID1IP1;CITED1;PQBP1;PHB2;ERCC4;PEX16
protein bindingAGFG1;ERLIN2;RG9MTD1;DUSP23;FOXP2;GTF3C3;CDKN2D;NLRX1;HSPA13
protein kinase activityPRKD2;RPS6KA3B;MAP2K4;CAMKK1B;CAMKV;MAP3K12;STK24;EPHA4B;ROCK1
tau-protein kinase activityPHKG1;MARK4;PHKG2;CDK5;GSK3B;MARK1;CSNK1D;MARK2;PRKAA1

PRKAA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAA1.

PRKAB2; PRKAG1

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