prkaa1
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  • Official Full Name
  • protein kinase, AMP-activated, alpha 1 catalytic subunit
  • Background
  • The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • PRKAA1; protein kinase, AMP-activated, alpha 1 catalytic subunit; 5-AMP-activated protein kinase catalytic subunit alpha-1; AMPK; alpha; 1; AMPKa1; AMPK alpha 1; AMPK subunit alpha-1; tau-protein kinase PRKAA1; AMP -activate kinase alpha 1 subunit; AMP-ac
Cat.#:PRKAA1-2953HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRKAA1 Protein, MYC/DDK-tagged
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Cat.#:PRKAA1-1944HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1, GST-tagged
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Cat.#:PRKAA1-371HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1 protein, His/MBP-tagged
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Cat.#:PRKAA1-372HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1 protein, His/MBP-tagged
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Cat.#:PRKAA1-373HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1 protein, His/MBP-tagged
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Cat.#:PRKAA1-40HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (combination of A1/B1/G2 subunits), GST-His-tagged
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Cat.#:PRKAA1-41HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (combination of A1/B1/G3 subunits), GST-His-tagged
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Cat.#:PRKAA1-42HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (combination of A1/B2/G1 subunits), GST-His-tagged
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Cat.#:PRKAA1-612HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PRKAA1
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Cat.#:PRKAA1-740HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKAA1, GST-His
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Cat.#:PRKAA1-76HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (A1/B2/G2), GST-His-tagged
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Cat.#:PRKAA1-775HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1 protein, His & T7-tagged
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Cat.#:PRKAA1-77HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (A1/B2/G3), GST-His-tagged
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Cat.#:Prkaa1-144RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Prkaa1(T172D), GST/MYC-tagged
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Cat.#:PRKAA1-4668RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKAA1 Protein
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Cat.#:PRKAA1-3399CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRKAA1
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Cat.#:PRKAA1-6131ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PRKAA1
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Cat.#:AMPK(A1/B2/G1)-244HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (A1/B2/G1), His-tagged, Active
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Cat.#:PRKAA1-1412HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKAA1 cell lysate
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Involved Pathway

PRKAA1 involved in several pathways and played different roles in them. We selected most pathways PRKAA1 participated on our site, such as FoxO signaling pathway, Regulation of autophagy, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
STK4; PIK3CB; PRKAA1; MDM2; PIK3CG; NRAS; KLF2; IKBKB; CCNG2; MAPK8
Regulation of autophagy
IFNPHI3; IFNPHI1; IFNA10; ATG10; IFNA1; PRKAA1; IFNA3; IFNA17; Ifna11; IFNA5
mTOR signaling pathway
AKT3A; PRR5; PIK3R3A; MTOR; PRKCBB; RPS6KA3; RRN3; ULK3; STK11; IKBKB
PIK-Akt signaling pathway
IFNA17; TSC2; CREB3L1; TLR4; NGF; CREB5; THBS3; FLT1; HRAS; COL4A1
AMPK signaling pathway
SREBF1; CD36; PPP2CB; CREB5; CREB3L4; ADIPOR1; AKT3; FBP1; PIK3CD; TSC1
Circadian rhythm
ARNTL; RORA; PER1; NPAS2; PER3; PRKAG1; PRKAA2; CUL1; CRY2; RBX1
Insulin signaling pathway
PTPRFB; TSC1A; EIF4E2RS1; SOCS1; RAPGEF1B; INS; HRASA; SOCS1A; MAPK10; INPPL1A
Adipocytokine signaling pathway
LEPA; RXRAA; PPARAB; AGRP; IKBKB; ADIPOQ; NPY; ACSL4B; G6PC; G6PC2
Oxytocin signaling pathway
ACTG1; CACNA2D4; MYLK2; FOS; CAMK4; RGS2; ROCK2; ELK1; PLCB4; PLCB1
Glucagon signaling pathway
GNAS; ACACA; CALM3; PRKAA2; PPP3R1; PPP3CA; CALML3; GCG; PKM2; PGAM2
Insulin resistance
RPS6KB1; INSRA; MAPK8; PPP1CBL; PPP1R3D; RELA; PRKAG2; RPS6KA3A; PYGL; INSB
Non-alcoholic fatty liver disease (NAFLD)
SDHD; PRKAA1; NDUFS1; ADIPOQ; RAC1; IKBKB; NFKB1; ADIPOR2; TRAF2; GSK3A
Hypertrophic cardiomyopathy (HCM)
MYL3; CACNA2D1; ITGA9; CACNG8; CACNA2D4; SGCA; CACNG1; MYH7; ITGB8; IL6

Protein Function

PRKAA1 has several biochemical functions, for example, AMP-activated protein kinase activity, ATP binding, [acetyl-CoA carboxylase] kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAA1 itself. We selected most functions PRKAA1 had, and list some proteins which have the same functions with PRKAA1. You can find most of the proteins on our site.
Function
Related Protein
Function AMP-activated protein kinase activity
Related Protein PRKAA2; ALPK2; PRKAB1; PRKAA1; PRKAG3; PRKAG2
Function ATP binding
Related Protein UBA1; ABCA7; KIF4A; SRMS; MOV10B.1; PRKY; HKDC1; NTRK3A; ABCF2A; PDIK1L
Function [acetyl-CoA carboxylase] kinase activity
Related Protein PRKAA1; PRKAA2
Function [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
Related Protein PRKAA2; PRKAA1
Function cAMP-dependent protein kinase activity
Related Protein PRKAA1; PRKACG; PRKX; PRKACA; PRKACB; AKAP13; PRKAG1
Function chromatin binding
Related Protein FOXO1; ING2; DNAJC2; MEOX1; CENPA; CEBPB; NSBP1; FOSL2; BAHD1; DNMT3A
Function histone serine kinase activity
Related Protein AURKA; PRKAA2; AURKB; ATM; PRKAA1; AURKC
Function kinase binding
Related Protein BARD1; JAKMIP1; CDC6; BCL10; ABI2; JAKMIP2; STX1A; DLG3; PFKM; TRADD
Function metal ion binding
Related Protein SP8B; ZIC5; LMO4B; HE2; EGR1; ARAP3; ZNF572; MAT2AA; CPEB1; JMJD5
Function protein C-terminus binding
Related Protein TERF2; VIM; TOP2A; PROP1; NCF2; NPAT; TRP53; YWHAQ; PEX10; ATF4
Function protein binding
Related Protein SLC38A2; DNM1; ZFPL1; DHRS2; CDC5L; BAI2; TTI1; MEIS1; LIN28B; CLIP1
Function protein kinase activity
Related Protein PRKCI; PRPF4B; RPS6KB1; PAK1; PKN1B; NRBP2; CDK7; CSNK1E; MAP4K3; NPR1A
Function tau-protein kinase activity
Related Protein PRKAA1; CDK5; MARK4; PHKG1; GSK3B; PHKG2; MARK2; CSNK1D; MARK1; GSK3A

Interacting Protein

PRKAA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAA1.
PRKAB2; PRKAG1