prkaa1
Share
  • Official Full Name
  • protein kinase, AMP-activated, alpha 1 catalytic subunit
  • Background
  • The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • PRKAA1; protein kinase, AMP-activated, alpha 1 catalytic subunit; 5-AMP-activated protein kinase catalytic subunit alpha-1; AMPK; alpha; 1; AMPKa1; AMPK alpha 1; AMPK subunit alpha-1; tau-protein kinase PRKAA1; AMP -activate kinase alpha 1 subunit; AMP-ac
Cat.#:PRKAA1-2953HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRKAA1 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:PRKAA1-1944HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1, GST-tagged
+Inquiry
Cat.#:PRKAA1-371HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1 protein, His/MBP-tagged
+Inquiry
Cat.#:PRKAA1-372HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1 protein, His/MBP-tagged
+Inquiry
Cat.#:PRKAA1-373HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1 protein, His/MBP-tagged
+Inquiry
Cat.#:PRKAA1-40HTag:GST|His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (combination of A1/B1/G2 subunits), GST-His-tagged
+Inquiry
Cat.#:PRKAA1-41HTag:GST|His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (combination of A1/B1/G3 subunits), GST-His-tagged
+Inquiry
Cat.#:PRKAA1-42HTag:GST|His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (combination of A1/B2/G1 subunits), GST-His-tagged
+Inquiry
Cat.#:PRKAA1-612HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PRKAA1
+Inquiry
Cat.#:PRKAA1-740HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKAA1, GST-His
+Inquiry
Cat.#:PRKAA1-76HTag:GST|His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (A1/B2/G2), GST-His-tagged
+Inquiry
Cat.#:PRKAA1-775HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1 protein, His & T7-tagged
+Inquiry
Cat.#:PRKAA1-77HTag:GST|His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (A1/B2/G3), GST-His-tagged
+Inquiry
Cat.#:Prkaa1-144RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Prkaa1(T172D), GST/MYC-tagged
+Inquiry
Cat.#:PRKAA1-4668RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKAA1 Protein
+Inquiry
Cat.#:PRKAA1-3399CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRKAA1
+Inquiry
Cat.#:PRKAA1-6131ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PRKAA1
+Inquiry
Cat.#:AMPK(A1/B2/G1)-244HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (A1/B2/G1), His-tagged, Active
+Inquiry
Cat.#:PRKAA1-1412HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PRKAA1 cell lysate
+Inquiry

Involved Pathway

PRKAA1 involved in several pathways and played different roles in them. We selected most pathways PRKAA1 participated on our site, such as FoxO signaling pathway, Regulation of autophagy, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
TGFB1A; GADD45BB; PLK2B; BNIP4; PIK3R3; INSR; IGF1; PRKAG1; IGF1R; FOXO3
Regulation of autophagy
Ifna15; INS2; ATG10; IFNA21; INS1; IFNA1; GABARAP; IFNG1-2; IFNA17; GABARAPA
mTOR signaling pathway
ULK3; PIK3R3B; RICTOR; HIF1A; PTENA; RPS6KB2; IKBKB; PRKCBB; RPS6KB1B; RPTOR
PIK-Akt signaling pathway
YWHAB; ITGB5; IFNAR1; PRLR; RXRA; PDGFRB; PIK3CB; PPP2R2D; RPTOR; PPP2R5B
AMPK signaling pathway
HNF4A; EEF2K; PRKAG3; EEF2; PPP2R5D; Scd2; RAB10; PRKAA2; PPP2R2D; AKT1S1
Circadian rhythm
NR1D1; RORB; RBX1; RORA; SKP1; PRKAB1; CSNK1E; CUL1; PER2; RORC
Insulin signaling pathway
SHC2; PRKAG3B; CALML3; PRKAR2B; PDPK1; RAF1B; ARAF; PHKB; PIK3R3A; TSC1
Adipocytokine signaling pathway
RXRGB; PRKAA2; ACSL4A; ACSL3; STK11; G6PC2; ACSBG2; SLC2A4; IRS1; PRKAB2
Oxytocin signaling pathway
PRKAG2; PLA2G4F; PLCB3; GNAQ; ROCK1; PIK3R2; RAF1; PPP1R12A; RYR1; NFATC2
Glucagon signaling pathway
PYGM; CPT1C; PHKG1; PPP3CA; PDHB; LDHC; PYGB; PGAM2; PGAM1; ATF4
Insulin resistance
PRKAG3B; STAT3; PCK2; SLC27A1A; PPP1CBL; PRKAA2; CREB3L2; PYGB; PRKAB2; OGT.1
Non-alcoholic fatty liver disease (NAFLD)
NDUFAB1; NDUFA1; NDUFA12; NDUFV3; ADIPOQ; CEBPA; UQCR10; FASLG; NDUFA10; MLXIPL
Hypertrophic cardiomyopathy (HCM)
SGCG; ITGB4; PRKAG2; TNNC1; ITGA10; CACNG1; DAG1; TNF; ITGB1; ITGA1

Protein Function

PRKAA1 has several biochemical functions, for example, AMP-activated protein kinase activity, ATP binding, [acetyl-CoA carboxylase] kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAA1 itself. We selected most functions PRKAA1 had, and list some proteins which have the same functions with PRKAA1. You can find most of the proteins on our site.
Function
Related Protein
Function AMP-activated protein kinase activity
Related Protein PRKAG3; PRKAG2; PRKAA1; PRKAB1; PRKAA2; ALPK2
Function ATP binding
Related Protein RAD51L3; BCS1L; UBE2L3B; SBK3; MYO3B; UBE2N; ULK1A; ABL1; ATP12A; PRKCI
Function [acetyl-CoA carboxylase] kinase activity
Related Protein PRKAA1; PRKAA2
Function [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
Related Protein PRKAA2; PRKAA1
Function cAMP-dependent protein kinase activity
Related Protein PRKACA; PRKAG1; PRKACG; PRKACB; PRKX; AKAP13; PRKAA1
Function chromatin binding
Related Protein HIST2H3C1; MBD1; CENPA; TWIST2; MITF; MTA1; CEBPB; MCMBP; SIX1; ELK1
Function histone serine kinase activity
Related Protein AURKC; PRKAA1; AURKA; ATM; AURKB; PRKAA2
Function kinase binding
Related Protein PPP2R5A; LDHB; PTPN22; PIP5K1A; RB1; STRADA; DLG1; BTG1; JAKMIP1; BCL10
Function metal ion binding
Related Protein ERI1; ZBTB7C; CYP2P7; CYP2C39; ROCK2; PDE4D; MZF1; SOBPA; ADHFE1; ZFP82
Function protein C-terminus binding
Related Protein PEX26; MED12; LCK; VPS4A; HOMER3; NEIL1; MAPRE1; SDC1; SIAH1; CDC20
Function protein binding
Related Protein CSDE1; COA3; CD160; RPS6KA2; MINOS1; COL17A1; TERF2; FKBP7; KRT80; FBXW9
Function protein kinase activity
Related Protein DYRK1B; SOX9; DYRK3; JAK2A; CSNK1G2B; RPS6KA3; OXSR1B; PDK3; STK26; PAK1
Function tau-protein kinase activity
Related Protein PHKG2; MARK2; CSNK1D; MARK4; MARK1; PRKAA1; GSK3B; PHKG1; GSK3A; CDK5

Interacting Protein

PRKAA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAA1.
PRKAB2; PRKAG1