ptpn11
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  • Official Full Name
  • protein tyrosine phosphatase, non-receptor type 11
  • Background
  • The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified.
  • Synonyms
  • PTPN11; protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433
Cat.#:PTPN11-31402THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN11 protein, GST-tagged
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Cat.#:PTPN11-519HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN11 Protein, His-tagged
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Cat.#:Ptpn11-8674MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ptpn11, His tagged
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Cat.#:PTPN11-4830RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTPN11 Protein
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Cat.#:PTPN11-3705RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PTPN11 Protein, His-tagged
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Cat.#:PTPN11-6527CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTPN11
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Cat.#:PTPN11-1518HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTPN11 (Active), GST-tagged
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Cat.#:PTPN11-461HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN11, GST-tagged, Active
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Cat.#:PTPN11-1334MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse PTPN11 cell lysate
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Involved Pathway

PTPN11 involved in several pathways and played different roles in them. We selected most pathways PTPN11 participated on our site, such as Ras signaling pathway, Phospholipase D signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
PIK3CA; ELK1; MAPK9; HTR7; ANGPT2; PLCG2; PIK3R5; RAB5C; PIK3R1; RELA
Phospholipase D signaling pathway
PLA2G4A; PIP5K1B; MAPK1; GRM4; CXCR1; PLA2G4F; GRM1; PIK3CB; GRM7; GRM2
Jak-STAT signaling pathway
PIK3CA; GRB2; SOCS4; IL9R; MTOR; FHL1B; CISHB; IFNA7; M17; HRASB
Natural killer cell mediated cytotoxicity
ULBP1; PAK1; NCR1; TNF; IFNG; PRKCB; CD48; SH2D1B; MAP2K2; TNFRSF10A
Leukocyte transendothelial migration
RHOH; CLDN18; PTK2B; OCLN; NOX3; MYL9; CDH5; MSN; F11R; RAC1
Neurotrophin signaling pathway
KRAS; BRAF; IRAK1; MAPK8; TRAF6; IRS1; CALM1; CALML5; BAD; MAPK7
Adipocytokine signaling pathway
PRKAG2A; IKBKB; LEPB; MAPK8; MAPK8A; PTPN11A; CPT1B; POMC; SOCS3B; ADIPOR2
Insulin resistance
PPP1R3C; PYGMA; PTPN11; FOXO1B; PRKAG2A; NFKB1; PIK3R3B; SLC2A1A; MAPK8B; PRKAB2
Epithelial cell signaling in Helicobacter pylori infection
MET; RAC1; PAK1; ATP6V1A; TJP1; ATP6V0A2; ATP6V1B1; MAPK13; MAPK12; MAP2K4
Herpes simplex infection
CD74A; EIF2AK4; CDC34; IFNA1; HCFC1A; Fasl; MAP3K7; SRPK1A; MED8; SRPK1B
Proteoglycans in cancer
IGF1R; PLCG2; HPSE2; PXN; FZD7; PIK3CB; SOS1; PPP1R12A; SLC9A1; ROCK1
Renal cell carcinoma
PAK2; TCEB1; ARNT; HRAS; HIF1A; RBX1; PIK3R2; BRAF; TCEB2; EP300
Chronic myeloid leukemia
TGFBR2; BRAF; TGFB3; BAD; PIK3R3; MAPK3; IKBKG; HDAC2; STAT5B; MDM2

Protein Function

PTPN11 has several biochemical functions, for example, D1 dopamine receptor binding, SH3/SH2 adaptor activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN11 itself. We selected most functions PTPN11 had, and list some proteins which have the same functions with PTPN11. You can find most of the proteins on our site.
Function
Related Protein
Function D1 dopamine receptor binding
Related Protein GNAS; DLG4; ARRB2; PTPN11; CAV2; ATP1A3; AGTR1A; DRD3
Function SH3/SH2 adaptor activity
Related Protein CHN2; CHN1; SKAP1; CD28; SHB; KHDRBS1; SH3BP2; CRKL; SH2B2; SH3BGRL
Function insulin receptor binding
Related Protein IGF1; IGF1R; DOK3; DOK1; IRS4; DOK5; IGF2; DOK7; GRB10; SNX2
Function insulin receptor substrate binding
Related Protein INSRR; GRB2; INSR; IGF1RB; PRKCZ; PTPN11; IGF1R; INSRB; PRKCD; PIK3CB
Function non-membrane spanning protein tyrosine phosphatase activity
Related Protein DUSP1; PTPN4; ACP1; PTPN18; PTPN11; PTPN9; PTPN12
Function peptide hormone receptor binding
Related Protein PTH; JAK2; NPPC; PTHLH; FYN; LEP; NPPA; PTHLHA; RUNDC3A; PTPN11
Function phospholipase binding
Related Protein APOC2; SERPINB1A; LMNB1; CALM; SELE; PDPK1; ARHGAP6; CALM2; PARK2; CALM3
Function phosphoprotein phosphatase activity
Related Protein PPM1AB; PTPN2A; CTDNEP1A; PPM1DA; PPTC7A; PPM1LB; CDC14A; PPM1E; PTPN23A; PHPT1
Function protein binding
Related Protein NAPG; SFRP4; C16orf87; NAA16; SRA1; GATA4; KIAA1191; CD274; STX12; GRIN3A
Function protein domain specific binding
Related Protein NEFL; YWHAG1; NR0B1; DDX6; LIN7C; MYO7A; YWHAQ; LIN7B; ARFIP2A; Akap2
Function protein tyrosine phosphatase activity
Related Protein MTMR2; PGP; MTMR1A; EYA1; PTPN2A; PTPRK; MDP1; EYA4; PTPREB; PTPRZ1
Function receptor tyrosine kinase binding
Related Protein PTPN11; ANXA5; ANGPT2; TP53; ZNF259; DNAJA3; GNB2L1; ZFP259; FLT3LG; PLCG1

Interacting Protein

PTPN11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN11 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN11.
GAB1

PTPN11 Related Articles

Bader-Meunier, B; Cave, H; et al. Are RASopathies new monogenic predisposing conditions to the development of systemic lupus erythematosus? Case report and systematic review of the literature. SEMINARS IN ARTHRITIS AND RHEUMATISM 43:217-219(2013).
Jiang, J; Jin, MS; et al. Increased expression of tyrosine phosphatase SHP-2 in Helicobacter pylori-infected gastric cancer. WORLD JOURNAL OF GASTROENTEROLOGY 19:575-580(2013).