ptpn11
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  • Official Full Name
  • protein tyrosine phosphatase, non-receptor type 11
  • Background
  • The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified.
  • Synonyms
  • PTPN11; protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433
Cat.#:PTPN11-31402THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN11 protein, GST-tagged
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Cat.#:PTPN11-519HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN11 Protein, His-tagged
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Cat.#:Ptpn11-8674MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ptpn11, His tagged
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Cat.#:PTPN11-4830RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTPN11 Protein
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Cat.#:PTPN11-3705RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PTPN11 Protein, His-tagged
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Cat.#:PTPN11-6527CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTPN11
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Cat.#:PTPN11-1518HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTPN11 (Active), GST-tagged
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Cat.#:PTPN11-461HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN11, GST-tagged, Active
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Cat.#:PTPN11-1334MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse PTPN11 cell lysate
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Involved Pathway

PTPN11 involved in several pathways and played different roles in them. We selected most pathways PTPN11 participated on our site, such as Ras signaling pathway, Phospholipase D signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
GAB1; CALML5; PLA2G2D; GAB2; RALGDS; MAPK3; RASAL2; PAK6; CDC42; GNG3
Phospholipase D signaling pathway
GRM4; PIP5K1A; CXCR1; AVPR2; AKT2; GRM3; DNM3; AVPR1A; MTOR; PRKCA
Jak-STAT signaling pathway
IFNG; CRFB16; MYCB; IL21; OSMR; STAM2; AOX4; SOCS2; Ifna11; MCL1A
Natural killer cell mediated cytotoxicity
KLRA8; SHC3; ITGB2L; ZAP70; PTPN11; NCR1; IFNA7; PIK3CD; ITGB2; SYK
Leukocyte transendothelial migration
MLLT4; ROCK2; GNAI3; JAM2; MYL10; RASSF5; CLDN2; PTPN11; CLDN4; OCLN
Neurotrophin signaling pathway
PRKCD; MAPK8; RPS6KA5; IRS1; MAPK1; NTRK2; MAPK3; PIK3CA; NTF3; CAMK2A
Adipocytokine signaling pathway
ACSL5; NPY; NFKB1; PRKAG3; TNFRSF1A; AKT2; ACSL1A; NFKBIA; SOCS3B; MTOR
Insulin resistance
SLC27A1A; OGT.1; PRKCB; SLC2A1A; PRKCD; PIK3CG; FOXO1; INS1; PYGL; GYS2
Epithelial cell signaling in Helicobacter pylori infection
CXCR1; RELA; ATP6V1E1; MET; MAP2K4; PTPN11; IKBKG; ATP6V0D2; ATP6V0B; NOD1
Herpes simplex infection
TBPL2; SFRS3B; HCFC2; SRSF1; PILRA; EP300; OAS3; SRSF7A; STAT1A; UBE2R2
Proteoglycans in cancer
PIK3R2; Ctsl; Fzd4; PIK3R3; Fasl; PIK3R1; ESR1; HRAS; MAPK3; GRB2
Renal cell carcinoma
TGFB2; RAP1A; EPAS1; EGLN2; HGF; NRAS; SOS1; PIK3R2; VHL; FH
Chronic myeloid leukemia
STAT5B; PIK3R5; RAF1; MDM2; CCND1; CRKL; TRP53; HDAC2; TGFBR1; MAPK1

Protein Function

PTPN11 has several biochemical functions, for example, D1 dopamine receptor binding, SH3/SH2 adaptor activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN11 itself. We selected most functions PTPN11 had, and list some proteins which have the same functions with PTPN11. You can find most of the proteins on our site.
Function
Related Protein
Function D1 dopamine receptor binding
Related Protein DRD3; DLG4; PTPN11; ARRB2; ATP1A3; GNAS; AGTR1A; CAV2
Function SH3/SH2 adaptor activity
Related Protein PAG1; SRC; GRAP; LASP1; CNTNAP1; CRKL; GRB14; EPS8; SH2D1A; GAB1
Function insulin receptor binding
Related Protein DOK7; IRS1; IGF2; DOK1B; DOK3; SHC1; INSL3; IRS4; INS2; SNX2
Function insulin receptor substrate binding
Related Protein PTPN11; INSR; PRKCZ; GRB2; INSRA; PRKCD; IGF1R; IGF1RA; PIK3R1; JAK2
Function non-membrane spanning protein tyrosine phosphatase activity
Related Protein PTPN4; PTPN11; ACP1; PTPN9; PTPN12; DUSP1; PTPN18
Function peptide hormone receptor binding
Related Protein PTPN11; NPPA; JAK2; NPPC; FYN; ADCYAP1; PTH; LEP; RUNDC3A; PTHLH
Function phospholipase binding
Related Protein CALM1; APOC2; SELE; WAS; SERPINB1A; CALM; CALM2; SNCA; CALM3; DGKQ
Function phosphoprotein phosphatase activity
Related Protein DUSP9; PTPRK; PPP5C; PPP2CA; CTDNEP1B; PPP3CC; PHLPP1; ACP2; PTPRZ1; PTPN20
Function protein binding
Related Protein DRAM1; AK8; LGALS6; SPG11; TEAD1; STAT4; ETV7; CCND3; HEYL; CNOT4
Function protein domain specific binding
Related Protein ICA1L; HIST1H4J; ESRRA; ETV6; LIN7C; ARFIP2B; DVL2; HOMER3; ARFIP2; MRPS31
Function protein tyrosine phosphatase activity
Related Protein PTPN11; MTMR6; MTMR7A; DUSP9; PTPN20; CDKN3; PTPRDB; DUSP4; MTMR1B; DUSP13
Function receptor tyrosine kinase binding
Related Protein ZFP259; SQSTM1; NRG3; TP53; PLCG1; NRG1; ANGPT2A; DOCK4; FIZ1; FNTA

Interacting Protein

PTPN11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN11 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN11.
GAB1

PTPN11 Related Articles

Bader-Meunier, B; Cave, H; et al. Are RASopathies new monogenic predisposing conditions to the development of systemic lupus erythematosus? Case report and systematic review of the literature. SEMINARS IN ARTHRITIS AND RHEUMATISM 43:217-219(2013).
Jiang, J; Jin, MS; et al. Increased expression of tyrosine phosphatase SHP-2 in Helicobacter pylori-infected gastric cancer. WORLD JOURNAL OF GASTROENTEROLOGY 19:575-580(2013).