rac1
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  • Official Full Name
  • ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
  • Background
  • The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
  • Synonyms
  • RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); MIG5; Rac-1; TC-25; p21-Rac1; ras-related C3 botulinum toxin substrate 1; ras-like protein TC25; cell migration-inducing gene 5 protein;
Cat.#:RAC1-445HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RAC1 Protein, MYC/DDK-tagged
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Cat.#:RAC1-189HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras-related C3 Botulinum Toxin Substrate 1
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Cat.#:RAC1-190HTag:His
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human RAC1, His-tagged
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Cat.#:RAC1-191HTag:His
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human RAC1(Q61L), His-tagged
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Cat.#:RAC1-192HTag:GST
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human RAC1, GST-tagged
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Cat.#:RAC1-193HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC1(Y72C) protein, His-tagged
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Cat.#:RAC1-194HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC1 protein, His-tagged
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Cat.#:RAC1-2147HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC1, His-tagged
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Cat.#:RAC1-2213HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RAC1, GST tagged
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Cat.#:RAC1-574HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RAC1
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Cat.#:RAC1-7034HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC1, GST-tagged
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Cat.#:RAC1-13857MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RAC1 Protein
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Cat.#:RAC1-4908RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RAC1 Protein
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Cat.#:RAC1-6574CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RAC1
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Cat.#:RAC1-712HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RAC1 cell lysate
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Involved Pathway

RAC1 involved in several pathways and played different roles in them. We selected most pathways RAC1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
GADD45AB; MAP4K3; TGFBR1; C11orf52; RAP1AA; CACNA1B; TNFRSF1A; HSPA6; RAF1; FGF7
Ras signaling pathway
KIT; FGF20; RAC1; RIN1; PAK3; MAPK3; TEK; FGF22; ANGPT4; AKT1
Rap signaling pathway
F2R; MLLT4; PRKD2; PRKCA; PIK3CB; FGF22; MET; CALML3; CALML5; ITGB2
cAMP signaling pathway
RRAS; CREB5; GRIN2B; PDE4B; ATP1B2; PDE3A; ACOX3; CREB3L1; TSHR; PDE3B
Chemokine signaling pathway
PRKACB; NFKBIB; VAV3; RAC2; AKT1; CCR1; CXCL3; RAC1; PLCB3; GNG4
Sphingolipid signaling pathway
RHOA; TRP53; S1PR5; PIK3CA; TNFRSF1A; MAPK12; PIK3CD; SPTLC2; MAP3K5; PIK3R5
Phagosome
ATP6V0A1; NCF2; M6PR; ACTB; TUBB2A; MHC2A; TLR2-2; ITGAM; LAMP2; HLA-DRB4
PIK-Akt signaling pathway
IL2RA; LPAR6; VEGFA; COL24A1; Fgf15; GNB2; ITGA5; IL3RA; FGF10; OSMR
Wnt signaling pathway
DAAM1B; PPARDB; SERPINF1; WNT9A; FZD8A; WNT9B; LRP5; PLCB3; CCND2A; MMP7
Axon guidance
NTN1; RASGEF1A; ROCK1; RHOGA; CD24; EPHA4; SEMA3E; CHL1; RAC1; TRPC7
VEGF signaling pathway
RAC3A; PPP3R1; SPHK2; PIK3CB; PIK3CD; PPP3R2; VEGFAA; RAF1A; MAPK12A; RAC3
Osteoclast differentiation
SFPI1; TEC; ITGB3; IL1R1; TAB2; FOSL2; MAP2K1; NCF4; TNF; IKBKB
Focal adhesion
BIRC2; ACTN3A; CAPN2L; ZYX; ITGA1; COL24A1; COL11A2; CCND1; PAK1; AASS
Adherens junction
ACTG1; RAC1B; PTPN1; NLK2; SMAD4; WASF1; RAC1; MET; PVRL1; WASB
Toll-like receptor signaling pathway
CXCL8B.3; MAPK13; MAPK12B; MAP2K2A; RIPK1; PIK3CA; CCL4; CD14; TLR5B; IFNA7
Natural killer cell mediated cytotoxicity
IFNG; NRAS; LAT; FCGR3; TYROBP; MAPK3; KLRD1; IFNA10; PIK3CD; SH3BP2
B cell receptor signaling pathway
RASGRP3; CARD11; PIK3CD; LCP2A; MALT1; MAP2K2; GRB2; NFKBIB; BTK; ARPC3
Fc epsilon RI signaling pathway
AKT2; LCP2; PLCG2; PIK3CD; MAP2K3; FCER1A; PIK3CB; KRAS; RAC2; LAT
Fc gamma R-mediated phagocytosis
PPAP2A; RAC1; PRKCE; VAV1; LYN; PIK3R5; SCIN; SPHK2; MARCKS; LIMK1
Leukocyte transendothelial migration
PIK3CB; MYL2; ICAM1; ITGAM; RAP1B; CLDN7; RAC1; CLDN23; VAV1; MYL10
Neurotrophin signaling pathway
RAP1B; IKBKB; RIPK2; RAP1A; PRKCD; PTPN11; NTF4; GAB1; NTRK3; TP53
Regulation of actin cytoskeleton
RAF1A; ITGAM; FGF20B; ROCK2B; MYL2B; PDGFRB; DIAP1; ITGB3B; MYL5; INSB
Non-alcoholic fatty liver disease (NAFLD)
PRKAG3; INS2; NFKB1; IKBKB; UQCR11; NDUFA3; TRAF2; TGFB1; SREBF1; Fasl
Pancreatic secretion
Cel; PLCB4; SLC9A1; AMY2A; CELA3B; PLCB3; RAP1A; CTRB1; BST1; FXYD2
Amyotrophic lateral sclerosis (ALS)
GRIA2; CYCS; MAP3K5; TOMM40L; RAC1; PPP3CA; Casp3; TNFRSF1B; NEFH; GPX1
Bacterial invasion of epithelial cells
CRK; CTTN; ARPC1B; ARPC5; RHOG; CAV2; HCLS1; ELMO2; ACTB; CLTB
Epithelial cell signaling in Helicobacter pylori infection
ATP6V0A1; ATP6V1B2; NFKBIA; ATP6V0D2; ATP6V1G2; RAC1; MAPK13; RELA; NOD1; ATP6AP1
Shigellosis
MAPK9; ROCK1; NFKB1; FBXW11; U2AF1L4; PFN2; SRC; UBE2D2; ARPC5L; MAPK11
Salmonella infection
RHOG; ROCK2B; MAPK11; KLC1B; ACTG1; IL1A; CD14; TLR5B; ROCK2A; CASPA
Pathways in cancer
LAMB1; HDAC2; TP53; LPAR5; ABL1; PDGFRB; PTGS2; IGF1R; DAPK1; MAPK3
Viral carcinogenesis
NRAS; MAPKAPK2; EP300; HIST1H2BD; HDAC7A; PSMC1; LYN; STAT5A; HIST1H2BB; HIST1H2BP
Proteoglycans in cancer
ARHGEF12; ESR1; ITGB3; PPP1R12A; WNT7B; WNT16; FZD6; TFAP4; PPP1CA; DDX5
Colorectal cancer
APC; Casp3; TCF7; RAF1; SMAD4; BRAF; AXIN2; RAC3; BAD; MSH3
Renal cell carcinoma
PIK3CB; GRB2; PIK3R5; SLC2A1; TGFB1; ETS1; HGF; RAP1A; HRAS; ARNT
Pancreatic cancer
AKT1; MAPK1; PIK3CA; RALGDS; PIK3R5; MAPK10; BCL2L1; PIK3R1; VEGFA; AKT2
Choline metabolism in cancer
PIK3CA; PIP5K1C; PDGFC; RHEB; FOS; MAPK1; PLA2G4A; SLC5A7; NRAS; PDGFB
Viral myocarditis
HLA-DQA1; CD86; HLA-DRB3; HLA-B; BID; HLA-DPA1; MYH7; HLA-DPB1; HLA-DRB4; EIF4G3

Protein Function

RAC1 has several biochemical functions, for example, GTP binding, GTPase activity, Rho GDP-dissociation inhibitor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAC1 itself. We selected most functions RAC1 had, and list some proteins which have the same functions with RAC1. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein EFTUD1; GIMAP7; GMPPB; RABL2B; RAB2B; SEPT8B; SEPT7B; RAB38; EHD1A; RHOAE
Function GTPase activity
Related Protein RAB9A; GEM; RAB11BB; RAB15; GNB3; GNG5; TUBA8L; ADSSL1; RAB3D; RAB14
Function Rho GDP-dissociation inhibitor binding
Related Protein RAC1; RHOA
Function enzyme binding
Related Protein MLEC; CBS; NR5A1; MLL5; RYR2; PEX5; PARP1; CAV1; HMOX1; HIF1A
Function protein binding
Related Protein ZFYVE9; TMSB4Y; DEDD; PSMB9; MYBBP1A; UNC119; ASB9; POLR3F; GSTP1; GABPB2
Function thioesterase binding
Related Protein TRAF1; TRAF3; TRAF6; HAUS7; TRAF5; TRAF4; CDC42; CALM; CALM2; ARF6

Interacting Protein

RAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAC1.
PAK1

RAC1 Related Articles

Yu, CH; Zhang, S; et al. Rac1 signaling regulates neutrophil-dependent tissue damage in experimental colitis. EUROPEAN JOURNAL OF PHARMACOLOGY 741:90-96(2014).
Kenny, HA; Chiang, CY; et al. Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. JOURNAL OF CLINICAL INVESTIGATION 124:4614-4628(2014).