rac1
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  • Official Full Name
  • ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
  • Background
  • The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
  • Synonyms
  • RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); MIG5; Rac-1; TC-25; p21-Rac1; ras-related C3 botulinum toxin substrate 1; ras-like protein TC25; cell migration-inducing gene 5 protein;
Cat.#:RAC1-445HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RAC1 Protein, MYC/DDK-tagged
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Cat.#:RAC1-189HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras-related C3 Botulinum Toxin Substrate 1
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Cat.#:RAC1-190HTag:His
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human RAC1, His-tagged
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Cat.#:RAC1-191HTag:His
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human RAC1(Q61L), His-tagged
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Cat.#:RAC1-192HTag:GST
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human RAC1, GST-tagged
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Cat.#:RAC1-193HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC1(Y72C) protein, His-tagged
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Cat.#:RAC1-194HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC1 protein, His-tagged
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Cat.#:RAC1-2147HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC1, His-tagged
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Cat.#:RAC1-2213HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RAC1, GST tagged
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Cat.#:RAC1-574HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RAC1
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Cat.#:RAC1-7034HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC1, GST-tagged
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Cat.#:RAC1-13857MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RAC1 Protein
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Cat.#:RAC1-4908RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RAC1 Protein
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Cat.#:RAC1-6574CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RAC1
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Cat.#:RAC1-712HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RAC1 cell lysate
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Involved Pathway

RAC1 involved in several pathways and played different roles in them. We selected most pathways RAC1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF1; C11orf52; CACNA1BA; CDC42L; TRAF6; CACNG8; DDIT3; PAK1; MAP3K7; PRKCG
Ras signaling pathway
GNB3; PIK3CA; HGF; FGF17; LAT; GNG5; SHC1; GNG13; PLCE1; FGFR4
Rap signaling pathway
FGF5; Adcy4; NGFR; CALM4; Itgam&Itgb2; ARAP3; FGF1; F2R; IGF1R; RHOA
cAMP signaling pathway
VAV1; RAC2; RAC1; GRIN2B; PPP1CC; TNNI3; CAMK2B; CREB3L2; RRAS; NFATC1
Chemokine signaling pathway
GNGT2; FGR; CXCL12; PIK3R2; GNG4; GNB1; GNB3; BRAF; NFKB1; ARRB1
Sphingolipid signaling pathway
PRKCB; SPHK2; MAPK12; NRAS; RAC1; SGPL1; TP53; MAPK8; LASS5; CERS2
Phagosome
HLA-DRA; HLA-DMB; ATP6V0A2B; MSR1; ATP6V1G2; SFTPD; ITGB1B.2; STX12; THBS2; RAB5AB
PIK-Akt signaling pathway
IFNA8; IL2RA; PDGFD; PIK3CG; ITGA5; RPS6; F2R; IL4; INS2; LPAR4
Wnt signaling pathway
SFRP2; DAAM1B; FBXW11; RAC1; DKK1B; TBL1XR1; AXIN1; BAMBIA; LEF1; PRICKLE1A
Axon guidance
EPHA3; EPHB3A; NRG4; PAK2; NRAS; ITSN1; MAPK3; FGF8B; NTN4; PSPN
VEGF signaling pathway
NRAS; HRASA; MAP2K2B; PXNA; CASP9; AKT2; PTK2AA; RAC3B; PRKCG; PRKCBB
Osteoclast differentiation
OSCAR; FOSL1; MAPK1; SPI1; PLCG2; PIK3R1; RAC1; LILRB4; IFNG; IFNGR1
Focal adhesion
COL6A1; COL5A1; RAF1A; ACTB; ELK1; CAPN2B; CCND3; THBS4B; ARHGAP5; CDC42L
Adherens junction
BAIAP2; SNAI2; IGF1R; EGFR; PTPRFB; PVRL1; CDC42L; LMO7A; PTPRB; RHOAC
Toll-like receptor signaling pathway
IFNA2; IFNA17; MAP2K4B; TLR5B; STAT1B; TLR1LB; MAP3K7; RIPK1L; CCL3; CXCL8B.3
Natural killer cell mediated cytotoxicity
NCR3; HLA-E; HCST; TNFRSF10C; FCGR4; MICA; HRAS; PIK3R5; PAK1; PIK3R1
B cell receptor signaling pathway
PIK3CG; CD79B; MAP2K2; SYK; cgr2b; PPP3CB; ARPC2; MAPK3; DOK3; NEDD9
Fc epsilon RI signaling pathway
RAC3; PDPK1; PLA2G4C; MAPK11; PRKCA; IL13; PIK3R2; VAV2; PLA2G4A; PLCG1
Fc gamma R-mediated phagocytosis
CFL1; AMPH; CDC42; ARPC5L; PPAP2B; WASF1; PIK3CA; BIN1; PLA2G6; PLCG2
Leukocyte transendothelial migration
NCF4; CTNNA3; CXCL12; VAV3; JAM2; PIK3CB; ROCK2; CLDN14; PRKCA; RASSF5
Neurotrophin signaling pathway
PIK3R5; TRP53; BCL2; RAP1A; RPS6KA5; PIK3R1; NFKBIB; AKT1; NTRK3; RPS6KA2
Regulation of actin cytoskeleton
INSB; PIP5K1B; MAP2K2B; PIP5K1BB; TMSB4X; MYLPF; LIMK2; SSH1; FGF6B; RAF1B
Non-alcoholic fatty liver disease (NAFLD)
AKT2; NDUFB8; CASP7; PRKAA1; RELA; LEPR; COX8C; NDUFA10; UQCRC1; NDUFC1
Pancreatic secretion
PLA2G2E; KCNQ1; PLA2G12A; SLC9A1; PRKCG; PLA2G2D; ATP2B1; RYR2; CPB1; PRSS3
Amyotrophic lateral sclerosis (ALS)
CAT; MAP2K6; NEFL; CASP9; DAXX; ALS2; GRIA2; GRIN2D; MAP2K3; TNF
Bacterial invasion of epithelial cells
ARPC3; CTNNA3; SRC; CLTB; PIK3R5; SEPT9; GAB1; MET; ARPC4; FN1
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1G2; MAPK13; PTPN11; MET; CDC42; ATP6V1C1; NOD1; MAPK10; F11R; GIT1
Shigellosis
ROCK2; ELMO1; ACTB; CD44; RIPK2; ABL1; MAPK13; WASF1; MAPK9; ATG5
Salmonella infection
WASB; CCL3L1; IFNG1-2; NOS2; WAS; MAPK14B; PFN3; MAPK11; CCL4; CCL3L3
Pathways in cancer
APC2; TRAF2; GLI2; BIRC8; TRAF1; PIAS2; WNT2; SMAD3; FLT3LG; PRKACA
Viral carcinogenesis
PIK3CD; HIST1H4E; SKP2; HIST1H4I; SNW1; HIST2H2BB; HIST1H4K; STAT3; ATP6V0D1; TRP53
Proteoglycans in cancer
IGF2; PTK2; FZD2; RPS6; DROSHA; HPSE2; WNT3; RPS6KB2; FZD8; CD44
Colorectal cancer
MLH1; CYCS; BAD; APC2; PIK3CG; FOS; SMAD2; RALGDS; PIK3CB; AKT2
Renal cell carcinoma
BRAF; PIK3CD; ARNT2; PIK3R1; MAPK1; RAC1; HIF1A; PIK3R3; NRAS; PAK7
Pancreatic cancer
MAPK9; MAPK3; MAP2K1; TGFBR1; TGFB2; PIK3R5; RB1; PIK3R3; RELA; TGFA
Choline metabolism in cancer
PLA2G4D; RAC3; TSC1; SLC22A5; PDGFRA; HIF1A; DGKQ; DGKD; PIP5K1A; PLA2G4B
Viral myocarditis
CD86; HLA-DRB3; HLA-A; ITGB2; LAMA2; EIF4G3; HLA-C; HLA-E; CD80; CD40

Protein Function

RAC1 has several biochemical functions, for example, GTP binding, GTPase activity, Rho GDP-dissociation inhibitor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAC1 itself. We selected most functions RAC1 had, and list some proteins which have the same functions with RAC1. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein LGALS6; SRL; GNAS; ARL13B; RALAB; SAR1AB; DNM2B; GPN3; RHOAB; GSPT2
Function GTPase activity
Related Protein RAB1BB; RAB33A; RAB20; RAB7A; RAB19; EEF1A1L2; TUBA1L2; ADSSL1; GNA13A; TUBA1L
Function Rho GDP-dissociation inhibitor binding
Related Protein RAC1; RHOA
Function enzyme binding
Related Protein SIRT1; CFTR; NFKBIA; ITGB3; HSPA1B; PPP3CB; GSTM3; GRIN1; TOP2B; SNRPD3
Function protein binding
Related Protein CKM; CREBZF; TLK2; RAI1; ING4; CHMP6; GDF7; USP44; RUNDC3A; BIRC7
Function thioesterase binding
Related Protein HAUS7; CALM1; ADRA2A; CALM; TRAF5; TRAF2; TRAF6; TRAF4; CALM2; ARF6

Interacting Protein

RAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAC1.
PAK1

RAC1 Related Articles

Yu, CH; Zhang, S; et al. Rac1 signaling regulates neutrophil-dependent tissue damage in experimental colitis. EUROPEAN JOURNAL OF PHARMACOLOGY 741:90-96(2014).
Kenny, HA; Chiang, CY; et al. Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. JOURNAL OF CLINICAL INVESTIGATION 124:4614-4628(2014).