rac1
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  • Official Full Name
  • ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
  • Background
  • The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
  • Synonyms
  • RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); MIG5; Rac-1; TC-25; p21-Rac1; ras-related C3 botulinum toxin substrate 1; ras-like protein TC25; cell migration-inducing gene 5 protein;
Cat.#:RAC1-445HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RAC1 Protein, MYC/DDK-tagged
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Cat.#:RAC1-189HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ras-related C3 Botulinum Toxin Substrate 1
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Cat.#:RAC1-190HTag:His
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human RAC1, His-tagged
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Cat.#:RAC1-191HTag:His
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human RAC1(Q61L), His-tagged
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Cat.#:RAC1-192HTag:GST
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human RAC1, GST-tagged
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Cat.#:RAC1-193HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC1(Y72C) protein, His-tagged
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Cat.#:RAC1-194HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC1 protein, His-tagged
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Cat.#:RAC1-2147HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC1, His-tagged
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Cat.#:RAC1-2213HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RAC1, GST tagged
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Cat.#:RAC1-574HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RAC1
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Cat.#:RAC1-7034HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAC1, GST-tagged
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Cat.#:RAC1-13857MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RAC1 Protein
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Cat.#:RAC1-4908RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RAC1 Protein
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Cat.#:RAC1-6574CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RAC1
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Cat.#:RAC1-712HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RAC1 cell lysate
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Involved Pathway

RAC1 involved in several pathways and played different roles in them. We selected most pathways RAC1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
EGFRA; CACNB4A; SOS1; CACNB3A; Casp3; CACNA2D1A; JUND; HRAS; MAPK3; MAPK12
Ras signaling pathway
RASAL1; CDC42; EFNA4; NGFR; CALML3; FGF18; FIGF; REL; PGF; RASSF5
Rap signaling pathway
ITGAM; FGF10; Adcy4; MAPK11; GNAI3; MAGI2; ITGB2; Kitl; KRIT1; FGF11
cAMP signaling pathway
PRKACG; BAD; AMH; ORAI1; MAP2K1; FSHB; GHRL; CALM2; MAPK10; GRIA3
Chemokine signaling pathway
GNG3; PIK3R2; CCL11; CCL8; STAT2; SOS1; CCL25; PRKACB; GNAI2; GRB2
Sphingolipid signaling pathway
TNFRSF1A; CERS2; RAC2; LASS4; PPP2R3C; MAPK3; PPP2R2A; RAF1; NSMAF; AKT2
Phagosome
SEC22B; TLR2-2; NCF1; TUBA8L2; RAB5AB; ACTB2; ATP6V1C1B; HLA-DPA1; TUBAL3; CALRL2
PIK-Akt signaling pathway
MAPK3; IFNA14; GNB1; MLST8; PPP2R1A; FGF4; FGF13; ITGA2; ITGA10; IBSP
Wnt signaling pathway
SFRP1; DVL3A; DAAM2; ROCK2; WNT2B; FOSL1; FZD2; FZD6; FZD7B; WNT7AA
Axon guidance
DUSP10; DLG3; CSNK2A2; SHB; CFL1; RND1; LRRC4C; DUSP5; FGF10B; Unc5b
VEGF signaling pathway
RAF1B; CDC42; PIK3CG; PTK2; PTK2AB; MAP2K1; MAPK12A; MAPK12; RAC3; RAC3A
Osteoclast differentiation
MAPK10; PIK3CA; TRAF6; TREM2; FHL2; FCGR2C; MAP3K14; IFNGR2; BLNK; NFKBIA
Focal adhesion
MAPK3; ITGB3; PIK3R2; CCND2A; PRKCB; MAPK10; ARHGAP5; FLT4; SHC4; COL27A1B
Adherens junction
SNAI2; ACTB2; INSR; SNAI1; NLK; SMAD4; PTPRFB; CTNNA3; RAC2; WASL
Toll-like receptor signaling pathway
IFNPHI1; PIK3R2; TBK1; IRAK1; MAP2K7; IFNA16; IFNAR2; CCL3; IFNA7; CRFB2
Natural killer cell mediated cytotoxicity
ZAP70; FCGR3A; KIR3DL1; Raet1a; MAP2K2; KIR2DS5; GM-CSF; IFNG; MICA; PIK3CD
B cell receptor signaling pathway
CD79A; PIK3R1; ARPC3; IKBKB; BCL2L11; MAPK3; NFATC3; RASGRP3; ARPC1B; DUSP6
Fc epsilon RI signaling pathway
IL4; MAP2K4; MAP2K2; PIK3R5; MAPK10; PLA2G4B; LAT; INPP5D; MAPK9; MAP2K1
Fc gamma R-mediated phagocytosis
RPS6KB1; NCF1; PIK3R1; GSN; PIK3CA; WASL; VASP; PIK3CG; HCK; FCGR1A
Leukocyte transendothelial migration
CLDN11; ESAM; MYLPF; MYL10; VAV2; RHOA; CLDN2; ACTN3; VCAM1; CLDN6
Neurotrophin signaling pathway
PIK3CD; RAP1A; SORT1; BDNF; NGFRAP1; SHC1; NTF3; AKT2; IRAK4; CALML3
Regulation of actin cytoskeleton
BRK1; RAF1A; WASB; VAV2; PDGFA; RHOAC; ITGB3; ITGAM; WASL; MSN
Non-alcoholic fatty liver disease (NAFLD)
IRS2; PRKAG2; NDUFS2; CEBPA; UQCR11; NDUFS3; Fasl; BAX; SDHA; IL1B
Pancreatic secretion
LOC780933; ATP2B4; PRSS3; RAP1B; PLA2G12A; ATP2A3; ATP1B1; CLCA2; CPB1; RAC1
Amyotrophic lateral sclerosis (ALS)
NOS1; PPP3CB; TOMM40L; PRPH; MAP2K3; CAT; PPP3CC; CCS; Casp3; GRIN2B
Bacterial invasion of epithelial cells
ELMO1; CTNNA2; CDH1; CBLC; PIK3R3; ARPC5L; SEPT11; RHOA; HCLS1; CRK
Epithelial cell signaling in Helicobacter pylori infection
CCL5; PLCG2; NFKB1; TJP1; GIT1; ATP6V1E2; IKBKB; IL-8; JAM2; CXCR1
Shigellosis
PFN3; MAD2L2; MAPK8; ACTG1; ROCK1; WASF1; MAPK11; ELMO2; IL-8; ITGB1
Salmonella infection
MAPK8A; ACTB; CCL4L1; ROCK2B; DYNC1LI1; PYCARD; TLR4; MAPK11; MAPK12B; RHOGC
Pathways in cancer
AGTR1A; EGLN1; CBLB; GNG4; FGFR3; PPARD; RUNX1T1; PDGFRB; LPAR3; STK36
Viral carcinogenesis
ACTN3; HIST2H2BE; EGR3; RBL1; YWHAE; HIST1H4G; CCND1; YWHAG; SP100; NFKB1
Proteoglycans in cancer
ROCK1; WNT3A; PRKCA; COL21A1; HOXD10; TIMP3; PLAUR; CBL; TLR4; SDC2
Colorectal cancer
MLH1; TP53; TGFBR2; LEF1; BAD; AKT1; PIK3R2; CASP9; MSH6; PIK3CG
Renal cell carcinoma
FH; ARNT; HRAS; PIK3CG; PIK3R1; MET; EP300; ARNT2; TGFA; PIK3CD
Pancreatic cancer
ARAF; MAPK8; PIK3R5; MAPK10; RAC3; SMAD4; BAD; PIK3CD; SMAD3; VEGFA
Choline metabolism in cancer
MAP2K2; PLA2G4C; GRB2; MAPK9; PRKCB; PIK3R5; PIP5K1C; TAE1; WASL; CHKA
Viral myocarditis
H2-Q10; ABL2; CYCS; HLA-E; CASP9; MYH7; CASP8; CAV1; SGCG; EIF4G2

Protein Function

RAC1 has several biochemical functions, for example, GTP binding, GTPase activity, Rho GDP-dissociation inhibitor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAC1 itself. We selected most functions RAC1 had, and list some proteins which have the same functions with RAC1. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein SEPT10; TUBA1L; RAB4A; ARL15A; EIF5B; EEF2A.1; RAB30; RHOC; NMUR2; GNAIA
Function GTPase activity
Related Protein ARL1; GNGT1; SEPT9; RALBB; RAB8A; GNL1; RAB31; RAP1B; TUBA8; TBCC
Function Rho GDP-dissociation inhibitor binding
Related Protein RHOA; RAC1
Function enzyme binding
Related Protein LUC7L2; APBA3; CTNNBL1; IL6R; DAXX; RPA3; MAT2B; PARP4; MSH2; GSTM3
Function protein binding
Related Protein CSN3; TXNRD1; MMRN2; SMG9; APLP1; BAIAP2; STK11; ADCYAP1; DHDDS; OAS1A
Function thioesterase binding
Related Protein TRAF2; ADRA2A; TRAF4; TRAF5; CALM2; TRAF3; CALM; HAUS7; CALM3; CDC42

Interacting Protein

RAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAC1.
PAK1

RAC1 Related Articles

Yu, CH; Zhang, S; et al. Rac1 signaling regulates neutrophil-dependent tissue damage in experimental colitis. EUROPEAN JOURNAL OF PHARMACOLOGY 741:90-96(2014).
Kenny, HA; Chiang, CY; et al. Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. JOURNAL OF CLINICAL INVESTIGATION 124:4614-4628(2014).