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Active Recombinant Human RAC1, His-tagged

Cat.No. : RAC1-190H
Product Overview : Recombinant Human RAC1, fused with His-tagged, was expressed in a bacterial expression system.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.
Source : Bacterial
Species : Human
Tag : His
Form : The protein is supplied as a lyophilized powder.
Bio-activity : The biological activity is determined by its ability to exchange nucleotide.
Molecular Mass : The recombinant protein is 22 kDa, consisting of the Rac1 protein plus a histidine tag in the amino-terminus.
Purity : >90% pure by SDS-PAGE
Storage : The protein is stable for six months if stored at -70ºC. The protein must not be exposed to repeated freeze-thaw cycles. The lyophilized protein is stable at 4ºC desiccated (<10% humidity) for six months.
Reconstitution : When it is reconstituted in distilled water to 1 mg/ml, the protein is in the following buffer: 2 mM Tris pH 7.6, 0.5 mM MgCl2, 0.5% sucrose, 0.1% dextran.
Gene Name : RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [ Homo sapiens (human) ]
Official Symbol : RAC1
Synonyms : RAC1; MGC111543; MIG5; TC-25; PAK1; TC25; P21-RAC1; RAC-1; p21-Rac1;Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); RAS-like protein; Ras-related C3 botulinum toxin substrate 1; rho family; small GTP binding protein Rac1; Ras-related C3 botulinum toxin substrate 1; Cell migration-inducing gene 5 protein; Ras-like protein TC25; migration-inducing gene 5; migration-inducing protein 5; ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); ras-related C3 botulinum toxin substrate 1 isoform Rac1; ras-related C3 botulinum toxin substrate 1 isoform Rac1b; rho family, small GTP binding protein Rac1
Gene ID : 5879
mRNA Refseq : NM_006908
Protein Refseq : NP_008839
MIM : 602048
UniProt ID : P63000
Chromosome Location : 7p22
Pathway : Adherens junction; Amyotrophic lateral sclerosis (ALS); Androgen receptor signaling pathway
Function : GTP binding; GTP-dependent protein binding; Rho GDP-dissociation inhibitor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing clinical trials targeting RAC1 for therapeutic purposes? 06/02/2019

Yes, there are clinical trials investigating the efficacy of RAC1-targeted therapies in various diseases, including cancer and inflammatory disorders.

How does RAC1 influence the progression of diabetic complications? 03/26/2019

RAC1 activation is implicated in the development of diabetic complications, particularly in the context of vascular dysfunction and diabetic nephropathy.

Can RAC1 be a biomarker for neurodegenerative diseases? 07/13/2018

Research suggests that altered RAC1 expression and activity may serve as a biomarker for certain neurodegenerative diseases.

In what ways does RAC1 impact neuronal function, and how does this relate to neurological disorders? 10/30/2016

RAC1 is crucial for neurite outgrowth and synaptic plasticity, and its dysregulation has been implicated in neurological disorders, suggesting a potential target for therapeutic interventions.

How does RAC1 contribute to cardiovascular diseases, and what are the potential therapeutic interventions? 03/07/2016

RAC1 is involved in vascular smooth muscle cell migration, and its dysregulation is associated with cardiovascular diseases. Targeting RAC1 may offer therapeutic benefits in such cases.

Customer Reviews (3)

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Reviews
05/03/2022

    RAC1 protein is highly recommended for researchers and scientists due to its exceptional performance in ELISA assays.

    12/20/2021

      Its reliability in ELISA makes it a trusted tool for quantitative and qualitative protein analysis.

      12/22/2018

        With its superior binding affinity and specificity, RAC1 protein enables accurate and reliable detection of target analytes in various biological samples.

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