ryr1
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  • Official Full Name
  • ryanodine receptor 1 (skeletal)
  • Background
  • Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is a protein found primarily in skeletal muscle. In humans, it is encoded by the RYR1 gene.
  • Synonyms
  • RYR1; ryanodine receptor 1 (skeletal); ryanodine receptor 1; skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; skeletal muscle-type ryanodine receptor; type 1 ryanodine receptor; RYR-1
Cat.#:RYR1-357HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RYR1
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Involved Pathway

RYR1 involved in several pathways and played different roles in them. We selected most pathways RYR1 participated on our site, such as Calcium signaling pathway, Circadian entrainment, Long-term depression, which may be useful for your reference. Also, other proteins which involved in the same pathway with RYR1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
AGTR1A; ATP2A2; MYLK; PPP3CA; HTR2CL1; PLCG2; CAMK2D2; TNNC1A; PRKCA; PHKG2
Circadian entrainment
PRKG1; CACNA1G; GRIA3; GNB2; KCNJ9; PER3; ITPR3; CALM4; PRKACA; GNAO1
Long-term depression
PRKCG; GRIA1; GNA13; IGF1; PRKG1; GNAI2; BRAF; PPP2CA; GUCY1A3; PRKCA
Oxytocin signaling pathway
PLA2G4D; HRAS; CALM3; ACTB; MAPK7; PIK3CD; Adcy4; CAMK2A; NPR2; NOS3

Protein Function

RYR1 has several biochemical functions, for example, calcium channel activity, calcium-release channel activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RYR1 itself. We selected most functions RYR1 had, and list some proteins which have the same functions with RYR1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium channel activity
Related Protein CACNA2D3; TRPV1; TRPM2; TRPV4; SLC24A4A; CACNG2B; TRPM6; CACNB2; CACNA1BA; CUL5
Function calcium-release channel activity
Related Protein JPH2; RYR1; JPH3; RYR3; RYR2; TRPV1; RASA3
Function calmodulin binding
Related Protein SLC14A2; RYR1; SLC9A1; STRN4; ADCY3; DDX5; ITPKB; TRPV1; ARPP21; NOS2
Function protease binding
Related Protein DERL1; SERPINB4; RFFL; THAP5; CD70; ECM1; ADAMTSL4; ITGB3; ITGB1; CNTNAP2
Function protein binding
Related Protein CDC42EP1; AGER; PAN2; AGL; CRCP; MARVELD2; POU2AF1; CTNNA3; HIST1H4F; BCL11A
Function ryanodine-sensitive calcium-release channel activity
Related Protein RYR2; RYR3; RYR1B; RYR1
Function voltage-gated calcium channel activity
Related Protein CACNG3; RYR1; CACNG7; CACNG2; CACNA1D; CACNA2D4; GRM7; GAS6; CACNA2D2; CACNA1C

Interacting Protein

RYR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RYR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RYR1.
MYOM2; PPP1CA; PPP2CA; NCK1; PLCG1; GRB2; TULP3; PDLIM3; TTN; TF

RYR1 Related Articles

Vukcevic, M; Zorzato, F; et al. Gain of function in the immune system caused by a ryanodine receptor 1 mutation. JOURNAL OF CELL SCIENCE 126:3485-3492(2013).
Thakur, P; Dadsetan, S; et al. Bidirectional Coupling between Ryanodine Receptors and Ca2+ Release-activated Ca2+ (CRAC) Channel Machinery Sustains Store-operated Ca2+ Entry in Human T Lymphocytes. JOURNAL OF BIOLOGICAL CHEMISTRY 287:37233-37244(2012).