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RYR1

Official Full Name

ryanodine receptor 1 (skeletal)
Overview

Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is a protein found primarily in skeletal muscle. In humans, it is encoded by the RYR1 gene.
Synonyms

RYR1; ryanodine receptor 1 (skeletal); ryanodine receptor 1; skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; skeletal muscle-type ryanodine receptor; type 1 ryanodine receptor; RYR-1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RYR1-357H	Recombinant Human RYR1	Mammalian Cell	His		Inquiry
Human	RYR1-789H	Recombinant Human RYR1 Protein (1-534 aa), His-tagged	E.coli	His	1-534 aa	Inquiry
Human	RYR1-790H	Recombinant Human RYR1 protein (Skeletal), His-tagged	E.coli	His	His97-Cys392	Inquiry
Human	RYR1-2037H	Recombinant Human RYR1 Protein, His&GST-tagged	E.coli	N-His&GST	His97-Cys392	Inquiry
Human	RYR1-4018H	Recombinant Human RYR1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	RYR1-301225H	Recombinant Human RYR1 protein, GST-tagged	E.coli	GST	Gly4942-Ser5038	Inquiry
Human	RYR1-4018H-B	Recombinant Human RYR1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Ryr1-2669M	Recombinant Mouse Ryr1 Protein, His&GST-tagged	E.coli	N-His&GST	His99-Cys394	Inquiry
Rat	Ryr1-2038R	Recombinant Rat Ryr1 Protein, His-tagged	E.coli	N-His	His99-Cys394	Inquiry

Involved Pathway
Protein Function
Interacting Protein
RYR1 Related Articles

RYR1 involved in several pathways and played different roles in them. We selected most pathways RYR1 participated on our site, such as Calcium signaling pathway, Circadian entrainment, Long-term depression, which may be useful for your reference. Also, other proteins which involved in the same pathway with RYR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium signaling pathway	PPIAA;TNNC1B;PRKACBA;P2RX8;DRD1A;ADORA2B;CALM1A;PLN;VDAC3
Circadian entrainment	GNG5;KCNJ9;PRKACG;PRKCA;PLCB1;GNG12;PRKG2;GNG11;PRKCB
Long-term depression	MAP2K1;PPP2CB;NOS1;CRHR1;GNAI3;KRAS;GUCY1A3;GNAZ;GRID2
Oxytocin signaling pathway	PRKAA2;RGS2;PIK3R1;MAP2K2;PLA2G4D;PPP3R1;MYLK3;PRKACA;PPP3CA

RYR1 has several biochemical functions, for example, calcium channel activity, calcium-release channel activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RYR1 itself. We selected most functions RYR1 had, and list some proteins which have the same functions with RYR1. You can find most of the proteins on our site.

Function	Related Protein
calcium channel activity	SLC24A4;TRPN1;TRPC5A;TMEM37;CACNG1A;TRPV6;TRPV3;RYR2;CHRNA9
calcium-release channel activity	JPH2;RYR2;RYR3;JPH3;RYR1;TRPV1;RASA3
calmodulin binding	PCDP1;NRGNA;KCNN2;PHKB;MYO1G;DAPK2;CNN2;ENKUR;MYH1B
protease binding	RFFL;SERPINB9;OS9;THAP5;SERPINA1A;TIMP2;FADD;HSPD1;SERPINB6
protein binding	CYBA;RBM22;PRPS1;HSP90AA1.2;ACTL8;KRTAP3-2;NEK3;TBC1D17;CHD8
ryanodine-sensitive calcium-release channel activity	RYR1;RYR2;RYR3;RYR1B
voltage-gated calcium channel activity	CACNB1;CACNB2A;RYR1;CACNG8;CACNA1SA;CACNG4;NCS1;NALCN;CACNG8A

RYR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RYR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RYR1.

MYOM2; PPP1CA; PPP2CA; NCK1; PLCG1; GRB2; TULP3; PDLIM3; TTN; TF

Vukcevic, M; Zorzato, F; et al. Gain of function in the immune system caused by a ryanodine receptor 1 mutation. JOURNAL OF CELL SCIENCE 126:3485-3492(2013).

Thakur, P; Dadsetan, S; et al. Bidirectional Coupling between Ryanodine Receptors and Ca2+ Release-activated Ca2+ (CRAC) Channel Machinery Sustains Store-operated Ca2+ Entry in Human T Lymphocytes. JOURNAL OF BIOLOGICAL CHEMISTRY 287:37233-37244(2012).