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SERPINB8

Official Full Name

serpin peptidase inhibitor, clade B (ovalbumin), member 8
Overview

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular;and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor;suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that;consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 (PubMed 2690952)). A critical portion of;the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member;of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high;degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a;serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 (PubMed;9268635)).
Synonyms

SERPINB8; serpin peptidase inhibitor, clade B (ovalbumin), member 8; PI8, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8; serpin B8; CAP2; cytoplasmic antiproteinase 2; CAP 2; CAP-2; OTTHUMP00000067000; OTTHUMP00000067001; Peptidase inhibitor 8; PI-8; PI8; Protease inhibitor 8 (ovalbumin type); Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 8; Serpin peptidase inhibitor clade B (ovalbumin) member 8; SPB8_HUMAN; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Insect Cell
Wheat Germ

Tag

GST
His
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SERPINB8-686H	Recombinant Human serpin peptidase inhibitor, clade B (ovalbumin), member 8, His-tagged	E.coli	His		Inquiry
Human	SERPINB8-31160TH	Recombinant Human SERPINB8	Wheat Germ	N/A	242 amino acids	Inquiry
Human	SERPINB8-2597H	Recombinant Human SERPINB8, GST-tagged	E.coli	GST	N-term-242aa	$319 / 25ug
Human	SERPINB8-2250H	Recombinant Human SERPINB8 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	SERPINB8-1005H	Recombinant Human SERPINB8 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	SERPINB8-465HF	Recombinant Full Length Human SERPINB8 Protein	In Vitro Cell Free System		242 amino acids	Inquiry
Mouse	SERPINB8-665MCL	Recombinant Mouse SERPINB8 cell lysate	Insect Cell	N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SERPINB8 Related Articles
SERPINB8 Related Research Area

SERPINB8 involved in several pathways and played different roles in them. We selected most pathways SERPINB8 participated on our site, such as Dissolution of Fibrin Clot, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINB8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Dissolution of Fibrin Clot	HRG;S100A10;ANXA2B;SERPINB8;ANXA2A;S100A10B;SERPINF2B;SERPINE2;S100A10A
Hemostasis	F3A;MAFGA;HBBE1.1;HBB-BH1;HMG20B;HBG1;SLC8A2A;ANXA2B;DOCK11

SERPINB8 has several biochemical functions, for example, protein binding, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINB8 itself. We selected most functions SERPINB8 had, and list some proteins which have the same functions with SERPINB8. You can find most of the proteins on our site.

Function	Related Protein
protein binding	NARG2;YWHAH;ANKRD27;PTGFRN;SETD8;FIG4;CAND2;GRAP;ZNF177
serine-type endopeptidase inhibitor activity	CD109;PEBP1;WFDC2;HRG;Serpina1b;SERPINH1;SERPINB1;WFDC6B;OVST

SERPINB8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINB8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINB8.

Lim, W; Kim, JH; et al. Avian SERPINB11 Gene: Characteristics, Tissue-Specific Expression, and Regulation of Expression by Estrogen. BIOLOGY OF REPRODUCTION 85:1260-1268(2011).

Fibrinolysis System