serpinb8
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  • Official Full Name
  • serpin peptidase inhibitor, clade B (ovalbumin), member 8
  • Background
  • The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular;and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor;suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that;consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 (PubMed 2690952)). A critical portion of;the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member;of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high;degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a;serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 (PubMed;9268635)).
  • Synonyms
  • SERPINB8; serpin peptidase inhibitor, clade B (ovalbumin), member 8; PI8, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8; serpin B8; CAP2; cytoplasmic antiproteinase 2; CAP 2; CAP-2; OTTHUMP00000067000; OTTHUMP00000067001; Peptidase inhibitor 8; PI-8; PI8; Protease inhibitor 8 (ovalbumin type); Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 8; Serpin peptidase inhibitor clade B (ovalbumin) member 8; SPB8_HUMAN; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8
Cat.#:SERPINB8-1005HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SERPINB8 Protein, MYC/DDK-tagged
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Cat.#:SERPINB8-2597HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPINB8, GST-tagged
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Cat.#:SERPINB8-31160THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SERPINB8
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Cat.#:SERPINB8-686HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human serpin peptidase inhibitor, clade B (ovalbumin), member 8, His-tagged
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Cat.#:SERPINB8-665MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SERPINB8 cell lysate
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Involved Pathway

SERPINB8 involved in several pathways and played different roles in them. We selected most pathways SERPINB8 participated on our site, such as Dissolution of Fibrin Clot, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINB8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Dissolution of Fibrin Clot
SERPINB8; S100A10A; ANXA2; SERPINE2; ANXA2A; S100A10B; HRG; S100A10; SERPINF2B; ANXA2B
Hemostasis
SLC7A6; SIRPA; HBBE3; CAP1; DGKG; LOC100514666; CFHL2; ANXA2; CD177; RHOGA

Protein Function

SERPINB8 has several biochemical functions, for example, protein binding, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINB8 itself. We selected most functions SERPINB8 had, and list some proteins which have the same functions with SERPINB8. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein TICAM1; THSD4; HIST2H3C; NPRL2; TAL1; PWWP2B; BNIPL; EXOSC7; EGF; UTP14A
Function serine-type endopeptidase inhibitor activity
Related Protein SPINK8; WFDC6; OVST; SPINT4; SERPING1; SERPINA11; SERPINB6B; SERPINA3M; SERPINB1C; KAL1

SERPINB8 Related Articles

Lim, W; Kim, JH; et al. Avian SERPINB11 Gene: Characteristics, Tissue-Specific Expression, and Regulation of Expression by Estrogen. BIOLOGY OF REPRODUCTION 85:1260-1268(2011).