serpine1
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  • Official Full Name
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
  • Background
  • This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
  • Synonyms
  • SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; PAI; PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpin E1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1;
Cat.#:SERPINE1-1003HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SERPINE1 Protein, MYC/DDK-tagged
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Cat.#:SERPINE1-5490HTag:N/A
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1
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Cat.#:Serpine1-100MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Serpine1 Protein, His-tagged
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Cat.#:Serpine1-2462MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Serpine1
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Cat.#:SERPINE1-2458HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SERPINE1, Active Form
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Cat.#:SERPINE1-2600HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPINE1, GST-tagged
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Cat.#:SERPINE1-2751HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPINE1 protein, His-tagged
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Cat.#:SERPINE1-28262THTag:
Source (Host):Species:Human
Product nameRecombinant Human SERPINE1
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Cat.#:SERPINE1-29521THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPINE1
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Cat.#:SERPINE1-30721THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPINE1
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Cat.#:SERPINE1-30724THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPINE1
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Cat.#:SERPINE1-30728THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPINE1
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Cat.#:SERPINE1-3158HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SERPINE1, His tagged
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Cat.#:SERPINE1-535HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPINE1, His-tagged
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Cat.#:Serpine1-2752MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Serpine1 protein, His & T7-tagged
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Cat.#:Serpine1 -81RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat PAI-1 wild type active fraction, His-tagged
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Cat.#:Serpine1 -98RTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Glycosylated Rat PAI-1 Stable Mutant
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Cat.#:Serpine1-2753RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Serpine1 protein, His & T7-tagged
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Cat.#:SERPINE1-5344RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SERPINE1 Protein
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Cat.#:Serpine1-564RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Serpine1, Fc-tagged
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Cat.#:Serpine1-565RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Serpine1, His-tagged
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Cat.#:SERPINE1 -88CTag:N/A
Source (Host):E. coliSpecies:Cynomolgus Monkey
Product nameRecombinant Cyno Monkey PAI-1 wild type active fraction
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Cat.#:SERPINE1 -89CTag:N/A
Source (Host):E. coliSpecies:Cynomolgus Monkey
Product nameRecombinant Cyno Monkey PAI-1 wild type latent fraction
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Cat.#:SERPINE1 -86DTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Dog
Product nameRecombinant Glycosylated canine (dog) PAI-1 Wild Type Latent Fraction
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Cat.#:SERPINE1-89CTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Canine
Product nameRecombinant Canine SERPINE1
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Cat.#:SERPINE1-90CTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Canine
Product nameRecombinant Canine SERPINE1
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Cat.#:SERPINE1-6435ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SERPINE1
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Cat.#:SERPINE1-87PTag:N/A
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Porcine PAI-1 wild type active form
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Cat.#:Serpine1-5282MTag:N/A
Source (Host):Mouse plasmaSpecies:Mouse
Product nameRecombinant Mouse Serine (or cysteine) Peptidase Inhibitor, Clade E, Member 1
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Cat.#:Serpine1-5319MTag:N/A
Source (Host):E. coli (PAI-1) + Insect cell culture (tPA)Species:Mouse
Product nameRecombinant Mouse Serine (or cysteine) Peptidase Inhibitor, Clade E, Member 1
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Cat.#:Serpine1-5310RTag:N/A
Source (Host):Rat plasmaSpecies:Rat
Product nameRecombinant Rat Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1
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Cat.#:SERPINE1-29522THTag:
Source (Host):E. coliSpecies:Human
Product nameNative Human SERPINE1
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Cat.#:SERPINE1-5514RTag:N/A
Source (Host):Rabbit PlasmaSpecies:Rabbit
Product nameNative Rabbit Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1
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Cat.#:SERPINE1-2383HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SERPINE1 cell lysate
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Cat.#:SERPINE1-001RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat SERPINE1 cell lysate
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Cat.#:Kit-0782Tag:
Source (Host):Species:
Product nameSERPINE1 (Human) Chromogenic Activity Assay Kit
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Cat.#:SERPINE1-122HTag:
Source (Host):CHOSpecies:Human
Product nameHuman Plasminogen Activator Inhibitor-1 (PAI-1), plasma Reference standard
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Involved Pathway

SERPINE1 involved in several pathways and played different roles in them. We selected most pathways SERPINE1 participated on our site, such as HIF- signaling pathway, p signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
HIF- signaling pathway
HKDC1; IFNG; PDK1; IGF1; INS; PGK1; VHL; LTBR; RPS6KB2; STAT3
p signaling pathway
SERPINE1; PTEN; THBS1; PIDD1; APAF1; TP53; EI24; SIAH1A; TP53AIP1; TP53I3
Hippo signaling pathway
WNT2; FZD2; PRKCZ; Fzd4; PPP1CB; SMAD1; TEAD3; LEF1; MOBKL1A; TEAD1
Complement and coagulation cascades
SERPINE1; SERPINA1; C8A; PROS1; SERPINA1A; C6; MBL1; SERPINA5; SERPING1; SERPINC1
Chagas disease (American trypanosomiasis)
CCL3L3; CD3D; FASLG; PPP2CB; FOS; TLR9; GNAI1; RELA; PIK3CA; Fasl

Protein Function

SERPINE1 has several biochemical functions, for example, protease binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINE1 itself. We selected most functions SERPINE1 had, and list some proteins which have the same functions with SERPINE1. You can find most of the proteins on our site.
Function
Related Protein
Function protease binding
Related Protein TNF; COMP; ITGB1; HSPD1; BDKRB2; RNF139; RFFL; SRI; F3; CCBE1
Function protein binding
Related Protein TAF9B; ELL; CBFB; CSDE1; RB1; KIAA0101; RPAP1; FGFR1; KRTAP3-1; CBX5
Function receptor binding
Related Protein TNFSF12; TENC1; GLA; ADCYAP1; FGF11; F7; CD2; STRAP; BMP3; SSFA2
Function serine-type endopeptidase inhibitor activity
Related Protein SPINT4; SERPINC1; SERPINB1L2; APP; SERPINI2; WFDC6B; TFPIA; SERPINB9; SERPINB1B; CD109

Interacting Protein

SERPINE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINE1.
SGTA; SGTB; UBQLN1; UBQLN1; ORM1; PLAU; PLAT; VTN; UBQLN4

SERPINE1 Related Articles

Yu, ZY; Lu, B; et al. Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1850:824-831(2015).
Dittmann, M; Hoffmann, HH; et al. A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation. CELL 160:631-643(2015).