Recombinant Human SERPINE1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: SERPINE1-2400H
• Product Overview: SERPINE1 MS Standard C13 and N15-labeled recombinant protein (NP_000593) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 45.1 kDa
• AA Sequence: MQMSPALTCLVLGLALVFGEGSAVH HPPSYVAHLASDFGVRVFQQVAQAS KDRNVVFSPYGVASVLAMLQLTTGG ETQQQIQAAMGFKIDDKGMAPALRH LYKELMGPWNKDEISTTDAIFVQRD LKLVQGFMPHFFRLFRSTVKQVDFS EVERARFIINDWVKTHTKGMISNLL GKGAVDQLTRLVLVNALYFNGQWKT PFPDSSTHRRLFHKSDGSTVSVPMM AQTNKFNYTEFTTPDGHYYDILELP YHGDTLSMFIAAPYEKEVPLSALTN ILSAQLISHWKGNMTRLPRLLVLPK FSLETEVDLRKPLENLGMTDMFRQF QADFTSLSDQEPLHVAQALQKVKIE VNESGTVASSSTAVIVSARMAPEEI IMDRPFLFVVRHNPTGTVLFMGQVM EPTRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: SERPINE1 serpin family E member 1 [ Homo sapiens (human) ]
• Official Symbol: SERPINE1
• Synonyms: SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; PAI1, PLANH1, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; plasminogen activator inhibitor 1; PAI; plasminogen activator inhibitor; type I; serpin E1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; PAI1; PAI-1; PLANH1
• Gene ID: 5054
• mRNA Refseq: NM_000602
• Protein Refseq: NP_000593
• MIM: 173360
• UniProt ID: P05121