sigirr
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  • Official Full Name
  • single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
  • Background
  • Single Ig IL-1-related receptor is a protein that in humans is encoded by the SIGIRR gene.
  • Synonyms
  • SIGIRR; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single Ig IL-1-related receptor; single immunoglobulin domain IL1R1 related; TIR8; Single immunoglobulin domain containing IL1R related protein; Toll/interleukin 1 receptor 8; Ig IL1 related receptor; MGC110992; SIGIR_HUMAN; Single Ig IL 1 related receptor; Single Ig IL-1R-related molecule; Single Ig IL1R Related Molecule; Single immunoglobulin and toll interleukin 1 receptor (TIR) domain; Single immunoglobulin and toll interleukin 1 receptor domain; Single immunoglobulin domain-containing IL1R-related protein; TIR 8; Toll/interleukin-1 receptor 8; OTTHUMP00000229641; OTTHUMP00000229642; OTTHUMP00000229643; OTTHUMP00000229644; OTTHUMP00000229645; single immunoglobulin
Cat.#:SIGIRR-2054MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse SIGIRR Protein (1-117 aa), His-tagged
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Cat.#:SIGIRR-1681HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human SIGIRR
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Cat.#:SIGIRR-1950HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIGIRR protein, His-tagged
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Cat.#:SIGIRR-2422HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIGIRR, Fc Chimera
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Cat.#:SIGIRR-28784THTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIGIRR, Fc-tagged
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Cat.#:SIGIRR-28785THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIGIRR, His-tagged
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Cat.#:SIGIRR-3956HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIGIRR, His tagged
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Cat.#:SIGIRR-422HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIGIRR, Fc tagged
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Cat.#:SIGIRR-674HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human SIGIRR, Fc-tagged, Biotinylated
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Cat.#:Sigirr-1951MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sigirr protein, His & GST-tagged
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Cat.#:Sigirr-501MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Sigirr
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Cat.#:SIGIRR-772MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SIGIRR, Fc-His tagged
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Cat.#:Sigirr-1952RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sigirr protein, His-tagged
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Cat.#:SIGIRR-5400RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SIGIRR Protein
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Cat.#:SIGIRR-4376CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SIGIRR
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Cat.#:SIGIRR-5670ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SIGIRR
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Cat.#:SIGIRR-1091HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIGIRR cell lysate
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Cat.#:SIGIRR-2773MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SIGIRR cell lysate
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Involved Pathway

Sigirr involved in several pathways and played different roles in them. We selected most pathways Sigirr participated on our site, such as Activated TLR4 signalling, Immune System, Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with Sigirr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activated TLR4 signalling
PELI3; APPA; TANK; UBE2V1; MAPKAPK2B; SIGIRR; CHST13; NOD1; ATF2; CHUK
Immune System
IFI6; SH2D1B; MKRN1; USP18; SIGLEC11; BTR06; CFHL4; DYNC1I1; ICAM4; CRTAM
Innate Immune System
MGC174155; DUSP3B; GZMM; IRAK3; DEFB4B; TXNIP; PELI1; PPAPDC1B; SUGT1; CR1
MyD88:Mal cascade initiated on plasma membrane
SIGIRR; IRAK3
Toll Like Receptor 2 (TLR2) Cascade
SIGIRR
Toll Like Receptor 4 (TLR4) Cascade
CD180; SIGIRR; LY86
Toll Like Receptor TLR1:TLR2 Cascade
SIGIRR
Toll Like Receptor TLR6:TLR2 Cascade
SIGIRR

Protein Function

Sigirr has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Sigirr itself. We selected most functions Sigirr had, and list some proteins which have the same functions with Sigirr. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein SYK; MCM3; FAM167A; CAPN1; CRH; NEGR1; ZNF567; LIMK2; F2R; HSP90AA1.1

Interacting Protein

Sigirr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Sigirr here. Most of them are supplied by our site. Hope this information will be useful for your research of Sigirr.
RPN1; ENO2; yhdI

Sigirr Related Articles

Bulau, AM; Nold, MF; et al. Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:2650-2655(2014).
Trevisi, E; Amadori, M; et al. Evaluation of innate immune responses in bovine forestomachs. RESEARCH IN VETERINARY SCIENCE 96:69-78(2014).