Recombinant Mouse Sigirr

• Cat.No.: Sigirr-501M

Specification

• Species: Mouse
• Source: Mammalian Cells
• Tag: Non
• Description: Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, also known as SIGIRR is a member of the IL-1 receptor family. It acts as a negative regulator of interleukin (IL)-1 and lipopolysaccharide (LPS) signaling. It also plays a critical role in gut homeostasis, intestinal inflammation, and colitis-associated tumorigenesis by maintaining the microbial tolerance of the colonic epithelium.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse SIGIRR is Mr 39 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 63 kDa.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Storage And Stability: The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: Sigirr single immunoglobulin and toll-interleukin 1 receptor (TIR) domain [ Mus musculus ]
• Synonyms: Sigirr; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; TIR8; AI256711; MGC102426; single Ig IL-1 receptor related protein; single Ig IL-1R-related protein
• Gene ID: 24058
• mRNA Refseq: NM_023059
• Protein Refseq: NP_075546
• UniProt ID: Q9JLZ8
• Chromosome Location: 7 F5
• Function: receptor activity; transmembrane receptor activity